ANCC Medical-Surgical Nursing
Certification Practice Questions with
correct Answers 2025/2026 ( A+
GRADED 100% VERIFIED).
"Third-spacing" can cause which form of shock?
A. Anaphylactic
B. Hypovolemic
C. Septic
D. Cardiovascular - The correct Answer is: B. Hypovolemic
Third-spacing = movement of fluid out of the vascular system into the interstitial areas,
resulting in loss of fluid leading to hypovolemic shock
An 18-year-old male is admitted after a motor-vehicle accident with air-bag release. He
complains of chest tightness and is restless and anxious. Heart sounds are barely audible
on auscultation. The patient is most likely experiencing what condition?
A. Cardiac tamponade
B. Acute myocardial infarction
C. Pulmonary edema
D. Aortic aneurysm - The correct Answer is: A. Cardiac tamponade
We know that this patient sustained trauma to the chest. Cardiac tamponade occurs when
there is fluid build up around the heart that applies pressure to the heart and impairs its
ability to pump adequately. This can happen with trauma or uncontrolled bleeding from an
open heart procedure. Signs and symptoms include chest pain and pressure, muffled heart
tones, shortness of breath, and jugular vein distention
A 24 year-old factory worker with a history of asthma presents to the emergency
department with difficulty breathing. During the respiratory assessment of the patient, the
nurse would expect to auscultate:
A. diminished breath sounds and crackles in lung bases
B. moist crackles in lung bases
C. distant breath sounds and expiratory wheezes
D. bronchial breath sounds in lung bases - The correct Answer is: C. distant breath
sounds and expiratory wheezes
A 30 year-old man with chronic traumatic brain injury was admitted for a surgical
procedure and is to be discharged. The nurse should modify his discharge instructions by:
1|Page
,1. Providing detailed oral instructions
2. Providing detailed written instructions
3. Having him repeat the instructions
4. Having sustained eye contact during the instruction - The correct Answer is: 3.
Having him repeat the instructions
A 30-year-old female has been diagnosed with Cushing's syndrome. The nurse knows the
patient is most likely to exhibit which symptoms?
A. Hypertension and hirsutism
B. Hyperkalemia and obesity
C. Hypotension and anemia
D. Menstrual irregularities and hypoglycemia - The correct Answer is: A.
Hypertension and hirsutism
Hypertension may result from fluid retention due to mineralcorticoid excess, and they may
also exhibit hirsutism (abnormal hair growth).
For Answers (B, C, D) while they may also exhibit truncal or generalized obesity as well as
menstrual irregularities, it is patient's with Addison's Disease that would exhibit
Hyperkalemia, Hypoglycemia and Hypotension (it is the opposite in Cushing's Syndrome).
A 48 year-old patient with suspected gastrointestinal (GI) bleeding undergoes diagnostic
endoscopy, which determines the site of bleeding is a duodenal ulcer. The nurse explains
to the patient that bleeding ulcers are most commonly related to which of the following?
a. Intake of spicy foods
b. Use of salicylates
c. History of smoking
d. Severe retching and vomiting - The correct Answer is: b. Use of salicylates
Most bleeding ulcers are related to the presence of Helicobacter pylori or drug use,
especially aspirin and aspirin-containing produces (salicylates) or nonsteroidal
anti-inflammatory drugs. Severe retching and vomiting are associated with esophageal
bleeding. Spicy floods do not cause ulcers.
A 50-year-old woman weighs 85kg and has a history of cigarette smoking, high blood
pressure, high sodium intake, and sedentary lifestyle. When developing an individualized
care plan for her, the nurse determines that the most important risk factors for
peripheral artery disease that need to be modified are:
A. Weight and diet
B. Activity level and diet
C. Cigarette smoking and high blood pressure
D. Sedentary lifestyle and high blood pressure - The correct Answer is: C. Cigarette
smoking and high blood pressure
These really all need to be addressed but smoking most of all, especially combined with
high BP
2|Page
,A 60-year-old African American male who works as a soccer coach, is admitted with
hypertension. On admission his blood pressure was 210/108 mmHg. His last total
cholesterol level was 156 mg/dl, and a random blood glucose was 110 mg/dl. Which is
unalterable risk factor for hypertension?
A. His blood glucose level
B. His cholesterol level
C. His occupation
D. His ethnicity - The correct Answer is: D
Other risk factors: elevated serum lipids, DM, sedentary lifestyle
A 63 year old female patient contacts the clinic to report that she is has been extremely
fatigued, is sleeping 12 hours a night, is always cold and her hair is falling out. Which of the
following responses by the nurse is most appropriate?
A. You will have more energy if you walk 30 min every day.
B. You don't need to worry. Sleeping a lot is good for you.
C. Come in and see your health care provider today.
D. You should eat more green leafy vegetables. - The correct Answer is: C
A 68 year old woman is admitted to the surgical unit after a gastric resection for gastric
cancer. She states that she doesn't want anyone to see her in this condition, even her
husband. This nurse's best response is:
A. "Patients' rights protect your privacy. I won't allow anyone in."
B. "I've seen gastric cancer patients who look much worse. Don't worry."
C. "Would you like to talk to a social worker?"
D. "What about your condition worries you?" - The correct Answer is: D
A 75 year old patient complains to the clinical nurse that he is having difficulty sleeping.
Which of the following actions by the nurse is most appropriate?
A. Determine the patient's usual sleeping and waking patterns.
B. Suggest that the client abstain from alcohol and caffeine before bed time.
C. Recommend that client establish a bedtime routine.
D. Ask how much sleep the client required before retirement. - The correct Answer is: A
A classic finding in the patient with acute respiratory distress syndrome (ARDS) is:
A. Sudden hypocalcemia with tetany
B. Severe hyperkalemia
C. Hypoxia resistant to oxygen therapy
3|Page
, D. Hypercapnia - The correct Answer is: C. Hypoxia resistant to oxygen therapy
A client admitted to the hospital with a sickle cell crisis complains of severe abdominal,
hip, and knee pain. You observe an LVN accomplishing these client care tasks. Which one
requires that you, as charge nurse, intervene immediately?
A. The LVN encourages the client to use the ordered PCA.
B. The LVN positions cold packs on the client's knees.
C. The LVN places a "No Visitors" sign on the client's door.
D. The LVN checks the client's temperature every 2 hours. - The correct Answer is:
B. The LVN positions cold packs on the client's knees.
The joint pain that occurs in sickle cell crisis is caused by obstruction of blood flow by the
sickled red blood cells. The appropriate therapy for this client would be application of
moist heat to the joints to cause vasodilation and improve circulation.
(A) Because control of pain is a priority during sickle cell crisis, encouraging the client to
use the PCA is an appropriate therapy.
(C, D) While infection control is important in preventing and treating sickle cell crisis, there
is no need to restrict all visitors or to check the temperature every 2 hours.
A client complains of crushing chest pain that radiates to his left arm. Which of the
following treatments should you anticipate:
A. Aspirin, oxygen, nitroglycerin, and morphine
B. Aspirin, oxygen, nitroglycerin, and codeine
C. Oxygen, nitroglycerin, meperidine, and thrombolytics
D. Aspirin, oxygen, nitroprusside, and morphine - The correct Answer is: A. Aspirin,
oxygen, nitroglycerin, and morphine
MONA
A client with a past history of angina has had a total knee replacement. What will the
nurse teach the client prior to rehabilitation activities?
A. "Use analgesics even if you are not in pain."
B. "Take nitroglycerine prophylactically prior to activity."
C. "Take anti-inflammatory medications before you get out of bed."
D. "Do not exercise if you have knee pain." - The correct Answer is: B. "Take
nitroglycerine prophylactically prior to activity."
Participation in exercise may increase myocardial oxygen demand beyond the ability of
the coronary circulation to deliver enough oxygen to meet the increased need.
Nitroglycerin dilates coronary arteries within 5 minutes of use, ensuring that they will be
ready to meet the demand during exercise.
A client with acute myelogenous leukemia is receiving induction phase chemotherapy.
4|Page
Certification Practice Questions with
correct Answers 2025/2026 ( A+
GRADED 100% VERIFIED).
"Third-spacing" can cause which form of shock?
A. Anaphylactic
B. Hypovolemic
C. Septic
D. Cardiovascular - The correct Answer is: B. Hypovolemic
Third-spacing = movement of fluid out of the vascular system into the interstitial areas,
resulting in loss of fluid leading to hypovolemic shock
An 18-year-old male is admitted after a motor-vehicle accident with air-bag release. He
complains of chest tightness and is restless and anxious. Heart sounds are barely audible
on auscultation. The patient is most likely experiencing what condition?
A. Cardiac tamponade
B. Acute myocardial infarction
C. Pulmonary edema
D. Aortic aneurysm - The correct Answer is: A. Cardiac tamponade
We know that this patient sustained trauma to the chest. Cardiac tamponade occurs when
there is fluid build up around the heart that applies pressure to the heart and impairs its
ability to pump adequately. This can happen with trauma or uncontrolled bleeding from an
open heart procedure. Signs and symptoms include chest pain and pressure, muffled heart
tones, shortness of breath, and jugular vein distention
A 24 year-old factory worker with a history of asthma presents to the emergency
department with difficulty breathing. During the respiratory assessment of the patient, the
nurse would expect to auscultate:
A. diminished breath sounds and crackles in lung bases
B. moist crackles in lung bases
C. distant breath sounds and expiratory wheezes
D. bronchial breath sounds in lung bases - The correct Answer is: C. distant breath
sounds and expiratory wheezes
A 30 year-old man with chronic traumatic brain injury was admitted for a surgical
procedure and is to be discharged. The nurse should modify his discharge instructions by:
1|Page
,1. Providing detailed oral instructions
2. Providing detailed written instructions
3. Having him repeat the instructions
4. Having sustained eye contact during the instruction - The correct Answer is: 3.
Having him repeat the instructions
A 30-year-old female has been diagnosed with Cushing's syndrome. The nurse knows the
patient is most likely to exhibit which symptoms?
A. Hypertension and hirsutism
B. Hyperkalemia and obesity
C. Hypotension and anemia
D. Menstrual irregularities and hypoglycemia - The correct Answer is: A.
Hypertension and hirsutism
Hypertension may result from fluid retention due to mineralcorticoid excess, and they may
also exhibit hirsutism (abnormal hair growth).
For Answers (B, C, D) while they may also exhibit truncal or generalized obesity as well as
menstrual irregularities, it is patient's with Addison's Disease that would exhibit
Hyperkalemia, Hypoglycemia and Hypotension (it is the opposite in Cushing's Syndrome).
A 48 year-old patient with suspected gastrointestinal (GI) bleeding undergoes diagnostic
endoscopy, which determines the site of bleeding is a duodenal ulcer. The nurse explains
to the patient that bleeding ulcers are most commonly related to which of the following?
a. Intake of spicy foods
b. Use of salicylates
c. History of smoking
d. Severe retching and vomiting - The correct Answer is: b. Use of salicylates
Most bleeding ulcers are related to the presence of Helicobacter pylori or drug use,
especially aspirin and aspirin-containing produces (salicylates) or nonsteroidal
anti-inflammatory drugs. Severe retching and vomiting are associated with esophageal
bleeding. Spicy floods do not cause ulcers.
A 50-year-old woman weighs 85kg and has a history of cigarette smoking, high blood
pressure, high sodium intake, and sedentary lifestyle. When developing an individualized
care plan for her, the nurse determines that the most important risk factors for
peripheral artery disease that need to be modified are:
A. Weight and diet
B. Activity level and diet
C. Cigarette smoking and high blood pressure
D. Sedentary lifestyle and high blood pressure - The correct Answer is: C. Cigarette
smoking and high blood pressure
These really all need to be addressed but smoking most of all, especially combined with
high BP
2|Page
,A 60-year-old African American male who works as a soccer coach, is admitted with
hypertension. On admission his blood pressure was 210/108 mmHg. His last total
cholesterol level was 156 mg/dl, and a random blood glucose was 110 mg/dl. Which is
unalterable risk factor for hypertension?
A. His blood glucose level
B. His cholesterol level
C. His occupation
D. His ethnicity - The correct Answer is: D
Other risk factors: elevated serum lipids, DM, sedentary lifestyle
A 63 year old female patient contacts the clinic to report that she is has been extremely
fatigued, is sleeping 12 hours a night, is always cold and her hair is falling out. Which of the
following responses by the nurse is most appropriate?
A. You will have more energy if you walk 30 min every day.
B. You don't need to worry. Sleeping a lot is good for you.
C. Come in and see your health care provider today.
D. You should eat more green leafy vegetables. - The correct Answer is: C
A 68 year old woman is admitted to the surgical unit after a gastric resection for gastric
cancer. She states that she doesn't want anyone to see her in this condition, even her
husband. This nurse's best response is:
A. "Patients' rights protect your privacy. I won't allow anyone in."
B. "I've seen gastric cancer patients who look much worse. Don't worry."
C. "Would you like to talk to a social worker?"
D. "What about your condition worries you?" - The correct Answer is: D
A 75 year old patient complains to the clinical nurse that he is having difficulty sleeping.
Which of the following actions by the nurse is most appropriate?
A. Determine the patient's usual sleeping and waking patterns.
B. Suggest that the client abstain from alcohol and caffeine before bed time.
C. Recommend that client establish a bedtime routine.
D. Ask how much sleep the client required before retirement. - The correct Answer is: A
A classic finding in the patient with acute respiratory distress syndrome (ARDS) is:
A. Sudden hypocalcemia with tetany
B. Severe hyperkalemia
C. Hypoxia resistant to oxygen therapy
3|Page
, D. Hypercapnia - The correct Answer is: C. Hypoxia resistant to oxygen therapy
A client admitted to the hospital with a sickle cell crisis complains of severe abdominal,
hip, and knee pain. You observe an LVN accomplishing these client care tasks. Which one
requires that you, as charge nurse, intervene immediately?
A. The LVN encourages the client to use the ordered PCA.
B. The LVN positions cold packs on the client's knees.
C. The LVN places a "No Visitors" sign on the client's door.
D. The LVN checks the client's temperature every 2 hours. - The correct Answer is:
B. The LVN positions cold packs on the client's knees.
The joint pain that occurs in sickle cell crisis is caused by obstruction of blood flow by the
sickled red blood cells. The appropriate therapy for this client would be application of
moist heat to the joints to cause vasodilation and improve circulation.
(A) Because control of pain is a priority during sickle cell crisis, encouraging the client to
use the PCA is an appropriate therapy.
(C, D) While infection control is important in preventing and treating sickle cell crisis, there
is no need to restrict all visitors or to check the temperature every 2 hours.
A client complains of crushing chest pain that radiates to his left arm. Which of the
following treatments should you anticipate:
A. Aspirin, oxygen, nitroglycerin, and morphine
B. Aspirin, oxygen, nitroglycerin, and codeine
C. Oxygen, nitroglycerin, meperidine, and thrombolytics
D. Aspirin, oxygen, nitroprusside, and morphine - The correct Answer is: A. Aspirin,
oxygen, nitroglycerin, and morphine
MONA
A client with a past history of angina has had a total knee replacement. What will the
nurse teach the client prior to rehabilitation activities?
A. "Use analgesics even if you are not in pain."
B. "Take nitroglycerine prophylactically prior to activity."
C. "Take anti-inflammatory medications before you get out of bed."
D. "Do not exercise if you have knee pain." - The correct Answer is: B. "Take
nitroglycerine prophylactically prior to activity."
Participation in exercise may increase myocardial oxygen demand beyond the ability of
the coronary circulation to deliver enough oxygen to meet the increased need.
Nitroglycerin dilates coronary arteries within 5 minutes of use, ensuring that they will be
ready to meet the demand during exercise.
A client with acute myelogenous leukemia is receiving induction phase chemotherapy.
4|Page
