NAPLEX 2026 EXAM QUESTIONS WITH CORRECT VERIFIED ANSWERS | 100% PASS (A+ CERTIFIED)

NAPLEX 2026 EXAM QUESTIONS WITH CORRECT VERIFIED ANSWERS | 100% PASS (A+ CERTIFIED)Concentration dependent antibiotics (Cmax:MIC) Answer aminoglycosides, quinolones, daptomycin *goal: high peak, low trough dosing strategy: large dose, long interval Exposure-dependent antibiotics (AUC:MIC) Answer vancomycin, macrocodes, tetracyclines, polymyxins *goal: exposure over time dosing strategy: variable Time-dependent antibiotics (Time MIC) Answer B-lactams Goal: maintain drug level MIC for most of the dosing interval Dosing strategies: shorter dosing interval, extended for continuous infusions Penicillin VK Answer PO: first line for strep throat and mild non purulent skin infections Amoxicillin Answer First line for acute otitis media Drug of choice for infective endocarditis prophylaxis before dental procedure used in H. pylori treatment Augmentin (amox/clav) Answer first line for acute otitis media (recurrence) and bacterial sinusitis Dicloxacillin, nafcillin, oxacillin Answer covers MSSA only no renal dose adjustment needed Penicillin G Benzathine Answer Bicillin L-A BBW: not for IV use -- can cause cardiorespiratory arrest and death Indication: Syphillis Piperacillin/tazobactam Answer Zosyn active agains pseudomonas aeruginosa extended infusions (4 hours) can be used to maximize T MIC Cephalosporins Answer *not active against Enterococcus spp. or atypicals - gram negative coverage increases with each generation 1st gen: strep, staph (MSSA), some activity against GNR (PEK) 2nd gen: HNPEK (cefotetean and cefoxitin have added gram-negative anaerobic coverage - B. fragilis) 3rd gen: - cetriaxone, cefotaxime, cefdinir: resistant strep, MSSA, gram-positive anaerobes and resistant HNPEK - ceftazidime: no gram positive activity, covers Pseudomonas 4th gen: cefepime - broad GN activity (HNPEK, CAPES, Pseudomonas) and gram-positive similar to CTX 5th gen: ceftaroline - GN activity similar to CTX and broad GP activity, including MRSA ceftazidime/avibactam ceftolozane/tazobactam Answer similar spectrum to ceftazidime, but added activity against MDR Pseudomonas and MDR GNR *used for MDR GN organisms (including pseudomonas Cefiderocol Answer Siderophore cephalosporin approved for complicated UTI/Pyelo active against E. coli, enterobacter, klebsiella, proteus, pseudomonas Cephalexin (PO) Answer Keflex common uses: skin infections (MSSA), strep throat 1st gen: strep, staph (MSSA), some activity against GNR (PEK) Cefuroxime (PO) Answer common uses: AOM, CAP 2nd gen: HNPEK