Gastrointestinal tract
(GIT) Disorders
By
, Gastritis
Inflammation of the gastric mucosa
Acute gastritis
Acute mucosal inflammatory process , usually of
transient nature
Is frequently associated with
– Heavy use of NSAIDs
– Excessive alcohol consumption
– Heavy smoking
– Uraemia
2
,– Systemic infections
– Severe stress (e.g. trauma, burn, surgery)
– Ischemia and shock
Mechanisms include
Increased acid secretion with back diffusion
Decreased production of bicarbonate buffer
Reduced blood flow
Disruption of the adherent mucus layer
Direct damage to the epithelium
3
, • Morphologic changes include
oedema ,vascular congestion ,neutrophilic
infiltrate erosion
• Clinically may be asymptomatic or may
cause variable epigastric pain, nausea and
vomiting or may cause haemorrhage
4
(GIT) Disorders
By
, Gastritis
Inflammation of the gastric mucosa
Acute gastritis
Acute mucosal inflammatory process , usually of
transient nature
Is frequently associated with
– Heavy use of NSAIDs
– Excessive alcohol consumption
– Heavy smoking
– Uraemia
2
,– Systemic infections
– Severe stress (e.g. trauma, burn, surgery)
– Ischemia and shock
Mechanisms include
Increased acid secretion with back diffusion
Decreased production of bicarbonate buffer
Reduced blood flow
Disruption of the adherent mucus layer
Direct damage to the epithelium
3
, • Morphologic changes include
oedema ,vascular congestion ,neutrophilic
infiltrate erosion
• Clinically may be asymptomatic or may
cause variable epigastric pain, nausea and
vomiting or may cause haemorrhage
4
