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PHRM 864 Gout Exam Questions
and Answers A+ Graded (2025)
Define gout - CORRECT ANSWER-inflammatory response to precipitation of
monosodium nitrate crystals in both articular and non-articular tissues
hyperuricemia AND symptomatic
Gout: uric acid level - CORRECT ANSWER->6.8 mg/dL
Gout: epidemiology - CORRECT ANSWER-highest prevalence in high income
countries
impacted by genetics, diet, and environmental factors
2-3x more likely in American men
What two factors have contributed to the recent increase in gout incidence -
CORRECT ANSWER-aging population
obesity
Describe the pathophysiology of gout - CORRECT ANSWER-uric acid is the last
step in purine degradation
humans cannot convert uric acid to allantoin b/c they lack uricase
What can cause uric acid elevation? - CORRECT ANSWER-over production
under excretion
What can lead to underexcretion of uric acid - CORRECT ANSWER-dehydration
insulin resistance
acute alcohol intake
meds
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What can lead to overproduction of uric acid - CORRECT ANSWER-chronic
consumption alcohol
electrolyte abnormalities
cytotoxic drug
excessive dietary intake of proteins
What lab results would be expected in a patient with acute gouty arthritis? -
CORRECT ANSWER-increased serum uric acid
increased WBC [leukocytosis]
What are the complications of acute gouty arthritis? - CORRECT ANSWER-
nephrolithiasis
gouty nephropathy
tophi
What are the diagnostic criteria for gout? - CORRECT ANSWER-aspiration of
synovial fluid
clinical dx of sx
imaging
Describe aspiration of synovial fluid - CORRECT ANSWER-process of searching
for MSU crystals
provides definitive dx of gout
What makes up the clinical dx of sx for gout - CORRECT ANSWER-monoarticular
joint involvement of ankles or feet
recent similar episode
rapid onset of pain and swelling
erythema
male sex
hyperuricemia
What can be used to identify tophi in a gout patient? - CORRECT ANSWER-
ultrasound
PHRM 864 Gout Exam Questions
and Answers A+ Graded (2025)
Define gout - CORRECT ANSWER-inflammatory response to precipitation of
monosodium nitrate crystals in both articular and non-articular tissues
hyperuricemia AND symptomatic
Gout: uric acid level - CORRECT ANSWER->6.8 mg/dL
Gout: epidemiology - CORRECT ANSWER-highest prevalence in high income
countries
impacted by genetics, diet, and environmental factors
2-3x more likely in American men
What two factors have contributed to the recent increase in gout incidence -
CORRECT ANSWER-aging population
obesity
Describe the pathophysiology of gout - CORRECT ANSWER-uric acid is the last
step in purine degradation
humans cannot convert uric acid to allantoin b/c they lack uricase
What can cause uric acid elevation? - CORRECT ANSWER-over production
under excretion
What can lead to underexcretion of uric acid - CORRECT ANSWER-dehydration
insulin resistance
acute alcohol intake
meds
, www.stuvia.com/user/BRAINSCAPE1
What can lead to overproduction of uric acid - CORRECT ANSWER-chronic
consumption alcohol
electrolyte abnormalities
cytotoxic drug
excessive dietary intake of proteins
What lab results would be expected in a patient with acute gouty arthritis? -
CORRECT ANSWER-increased serum uric acid
increased WBC [leukocytosis]
What are the complications of acute gouty arthritis? - CORRECT ANSWER-
nephrolithiasis
gouty nephropathy
tophi
What are the diagnostic criteria for gout? - CORRECT ANSWER-aspiration of
synovial fluid
clinical dx of sx
imaging
Describe aspiration of synovial fluid - CORRECT ANSWER-process of searching
for MSU crystals
provides definitive dx of gout
What makes up the clinical dx of sx for gout - CORRECT ANSWER-monoarticular
joint involvement of ankles or feet
recent similar episode
rapid onset of pain and swelling
erythema
male sex
hyperuricemia
What can be used to identify tophi in a gout patient? - CORRECT ANSWER-
ultrasound
