PHRM 864 Exam 2 Exam Questions and Answers A+ Graded (2025).

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PHRM 864 Exam 2 Exam Questions
and Answers A+ Graded (2025)




Chemotherapy Induced Nausea Vomiting (CINV) complications - CORRECT
ANSWER-Dehydration, electrolyte abnormalities, fatigue, and depression

Anticipatory Nausea/Vomiting - CORRECT ANSWER-learned response
conditioned by severity and duration of previous emetic reactions from prior
cycles of chemotherapy; can be provoked by sight, sound, or smell

Acute Nausea/Vomiting - CORRECT ANSWER-emetic response correlating with
the administration of chemotherapy usually within 24 hours

Delayed Nausea/Vomiting - CORRECT ANSWER-emetic response occurring > 24
hours following the completion of chemotherapy; substance P binding to
neurokinin 1 may play a role

Breakthrough Nausea/Vomiting - CORRECT ANSWER-emetic response that
occurs even if on scheduled anti-emetics prior to chemotherapy

Refractory Nausea/Vomiting - CORRECT ANSWER-emetic response that persists
despite appropriate anti-emetics

CINV Pathophysiology - CORRECT ANSWER-1. Cytotoxic chemotherapy induced
damage to the epithelial cells lining the GI tract
2. large stores of serotonin is released from enterochromaffin cells lining the GI
tract
3. chemoreceptor trigger zone (CTZ) stimulated the vomiting center

What level of emetogenic chemotherapy increases the risk of CINV when
combined? - CORRECT ANSWER-level 3 or 4 agents combined increases the
emetogenicity of the regimen by 1 level per agent

CINV Risk Factors - CORRECT ANSWER-Women, younger, motion sickness
history, morning sickness history, previous CINV, anxiety

Highly Emetogenic Regimen A - CORRECT ANSWER-1. NK-1 antagonist (Pick 1)
2. Steroid: Dexamethasone
3. 5-HT3 antagonist (Pick 1)

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4. Atypical antipsychotic: Olanzapine

NK-1 (Substance P) antagonists for CINV - CORRECT ANSWER-Aprepitant oral,
aprepitant injectable emulsion, fosaprepitant, rolapitant, netupitant/palonosetron,
fornetupitant/palonosetron

Steroids for CINV - CORRECT ANSWER-Dexamethasone

5-HT3 antagonists for CINV - CORRECT ANSWER-Dolasetron, Granisetron,
Ondansetron, Palonosetron

Atypical antipsychotics for CINV - CORRECT ANSWER-Olanzapine

Highly Emetogenic Regimen B - CORRECT ANSWER-1. Atypical Antipsychotic:
Olanzapine
2. 5-HT3 Antagonist: Palonosetron
3. Steroid: Dexamethasone
+/- Lorazepam +/- H2 blocker or PPI

Highly Emetogenic Regimen C - CORRECT ANSWER-1. NK-1 Antagonist (Pick 1)
2. Steroid: Dexamethasone
3. 5-HT3 Antagonist (Pick 1)
+/- Lorazepam +/- H2 blocker or PPI

Moderately Emetogenic Regimen A - CORRECT ANSWER-1. Steroid:
Dexamethasone
2. 5-HT3 Antagonist (Pick 1)
+/- Lorazepam +/- H2 blocker or PPI

Moderately Emetogenic Regimen B - CORRECT ANSWER-1. Atypical
Antipsychotic: Olanzapine
2. 5-HT3 Antagonist: Palonosetron
3. Steroid: Dexamethasone
+/- Lorazepam +/- H2 blocker or PPI

Moderately Emetogenic Regimen C - CORRECT ANSWER-1. NK-1 Antagonist
(Pick 1)
2. Steroid: Dexamethasone
3. 5-HT3 Antagonist (Pick 1)
+/- Lorazepam +/- H2 blocker or PPI

Low Emetogenic Regimen (Pick 1) - CORRECT ANSWER-Dexamethasone,
Metoclopramide, Prochlorperazine, Dolasetron, granisetron, or ondansetron
+/- Lorazepam +/- H2 blocker or PPI

Delayed Nausea and Vomiting Regimen - CORRECT ANSWER-Involves the use of
one of the following:
- Dexamethasone
- NK-1 Antagonist