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PHRM 864 Exam 4 Exam Questions
and Answers A+ Graded (2025)
IBD - CORRECT ANSWER-mucosal inflammatory conditions with chronic or
recurring immune response and inflammation of the GI tract
Types of IBD - CORRECT ANSWER-ulcerative colitis (UC)
Crohn's disease (CD)
Ulcerative colitis - CORRECT ANSWER-muscosal inflammation that is *confined*
to the rectum and colon
crohn's disease - CORRECT ANSWER-transmural inflammation of GI tract that
can affect *any part* from mouth to anus
IBD Etiology - CORRECT ANSWER-autoimmune and non-autoimmune
microorganisms cause inflammation
smoking
NSAIDS/abx
smoking is protective in - CORRECT ANSWER-UC
smoking is damaging in - CORRECT ANSWER-CD
UC: Clinical Pearls - CORRECT ANSWER-superficial
diarrhea and bleeding
UC: Complications - CORRECT ANSWER-local
systemic
*extraintestinal*
UC: Toxicities - CORRECT ANSWER-toxic megacolon
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hemorrhage
dysplasia/colorectal cancer
UC: Toxicities- Toxic Megacolon - CORRECT ANSWER-severe and fatal
colonic distention
> 6cm
UC: Signs/sx - CORRECT ANSWER-abd cramping
BM's +/- *blood* +/- mucous
blurred vision
UC: Physical Exam - CORRECT ANSWER-hemorrhoids
anal fissures
abscess
ocular
UC: Labs - CORRECT ANSWER-*decreased* Hb/HCT
increased ESR, CRP
leukocytosis/hypoalbumenia
*fecal calprotein* and lactoferrin
CD: Clinical Pearls - CORRECT ANSWER-discontinuous (normal and diseased
bowel separate)
*strictures and obstruction*
less bleeding and carcinoma risk than UC
IBD extraintestinal manifestations - CORRECT ANSWER-nutrition deficiencies
hepatobiliary (hepatitis, cirrhosis, etc)
bone and joint (arthritis, osteopo.)
anemia
risk of VTE
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CD: Signs/Sx - CORRECT ANSWER-fever
abdominal pain
BM's
*fistulas*
CD: Physical Exam - CORRECT ANSWER-abdominal mass/tenderness
fissure
fistula
CD: Labs - CORRECT ANSWER-Hb/HCT
*increased WBCs*, ESR, CRP
fecal calprotein and lactoferrin
IBD: Diet - CORRECT ANSWER-no specific diet has shown to be beneficial
Proctocolectomy is only cureable for - CORRECT ANSWER-UC
IBD Pharm Therapy: Drug Classes - CORRECT ANSWER-ASA's
(aminosalicylates)
corticosteroids
immunomodulators
biologics
antimicrobials
IBD Pharm Therapy: Drug Classes- ASA's - CORRECT ANSWER-sulfasalazine
mesalamine (5-ASA)
IBD Pharm Therapy: Drug Classes- Corticosteroids - CORRECT ANSWER-
budesonide
hydrocortisone
prednisone
prednisolone
, www.stuvia.com/user/BRAINSCAPE1
IBD Pharm Therapy: Drug Classes- Immunomodulators - CORRECT ANSWER-
azathioprine
mercaptopurine (6-MP)
cyclosporine
methotrexate
IBD Pharm Therapy: Drug Classes- Antimicrobials - CORRECT ANSWER-
metronidazole
ciprofloxacin
When selecting agents for IBD, consider: - CORRECT ANSWER-choosing the
agent that releases at *site of inflammation*
caution pH dependent drugs with PPI's, H2RA's, and antacids
Sulfasalazine= - CORRECT ANSWER-sulfapyridine (inactive ingredient) +
mesalamine (5-ASA) (active ingredient)
which part of sulfasalazine causes ADR's? - CORRECT ANSWER-sulfapyridine
IBD Pharm Therapy: Corticosteroids- Clinical Pearls - CORRECT ANSWER-
systemic absorption possible w/ rectal formulations
budesonide is short-term use only
taper pred. treatment
Prednisone/Prednisolone monitoring - CORRECT ANSWER-DEXA bone scan in
patients > 60, osteoporosis risk, using for 3 months, and uses recurrently
IBD Pharm Therapy: AZA/6-MP Clinical Pearls - CORRECT ANSWER-long term
use
can use with other drugs
IBD Pharm Therapy: MTX Contraindications - CORRECT ANSWER-*pregnancy*
pleural efflusions
chronic liver disease
immunodeficiency
leukopenia
PHRM 864 Exam 4 Exam Questions
and Answers A+ Graded (2025)
IBD - CORRECT ANSWER-mucosal inflammatory conditions with chronic or
recurring immune response and inflammation of the GI tract
Types of IBD - CORRECT ANSWER-ulcerative colitis (UC)
Crohn's disease (CD)
Ulcerative colitis - CORRECT ANSWER-muscosal inflammation that is *confined*
to the rectum and colon
crohn's disease - CORRECT ANSWER-transmural inflammation of GI tract that
can affect *any part* from mouth to anus
IBD Etiology - CORRECT ANSWER-autoimmune and non-autoimmune
microorganisms cause inflammation
smoking
NSAIDS/abx
smoking is protective in - CORRECT ANSWER-UC
smoking is damaging in - CORRECT ANSWER-CD
UC: Clinical Pearls - CORRECT ANSWER-superficial
diarrhea and bleeding
UC: Complications - CORRECT ANSWER-local
systemic
*extraintestinal*
UC: Toxicities - CORRECT ANSWER-toxic megacolon
, www.stuvia.com/user/BRAINSCAPE1
hemorrhage
dysplasia/colorectal cancer
UC: Toxicities- Toxic Megacolon - CORRECT ANSWER-severe and fatal
colonic distention
> 6cm
UC: Signs/sx - CORRECT ANSWER-abd cramping
BM's +/- *blood* +/- mucous
blurred vision
UC: Physical Exam - CORRECT ANSWER-hemorrhoids
anal fissures
abscess
ocular
UC: Labs - CORRECT ANSWER-*decreased* Hb/HCT
increased ESR, CRP
leukocytosis/hypoalbumenia
*fecal calprotein* and lactoferrin
CD: Clinical Pearls - CORRECT ANSWER-discontinuous (normal and diseased
bowel separate)
*strictures and obstruction*
less bleeding and carcinoma risk than UC
IBD extraintestinal manifestations - CORRECT ANSWER-nutrition deficiencies
hepatobiliary (hepatitis, cirrhosis, etc)
bone and joint (arthritis, osteopo.)
anemia
risk of VTE
, www.stuvia.com/user/BRAINSCAPE1
CD: Signs/Sx - CORRECT ANSWER-fever
abdominal pain
BM's
*fistulas*
CD: Physical Exam - CORRECT ANSWER-abdominal mass/tenderness
fissure
fistula
CD: Labs - CORRECT ANSWER-Hb/HCT
*increased WBCs*, ESR, CRP
fecal calprotein and lactoferrin
IBD: Diet - CORRECT ANSWER-no specific diet has shown to be beneficial
Proctocolectomy is only cureable for - CORRECT ANSWER-UC
IBD Pharm Therapy: Drug Classes - CORRECT ANSWER-ASA's
(aminosalicylates)
corticosteroids
immunomodulators
biologics
antimicrobials
IBD Pharm Therapy: Drug Classes- ASA's - CORRECT ANSWER-sulfasalazine
mesalamine (5-ASA)
IBD Pharm Therapy: Drug Classes- Corticosteroids - CORRECT ANSWER-
budesonide
hydrocortisone
prednisone
prednisolone
, www.stuvia.com/user/BRAINSCAPE1
IBD Pharm Therapy: Drug Classes- Immunomodulators - CORRECT ANSWER-
azathioprine
mercaptopurine (6-MP)
cyclosporine
methotrexate
IBD Pharm Therapy: Drug Classes- Antimicrobials - CORRECT ANSWER-
metronidazole
ciprofloxacin
When selecting agents for IBD, consider: - CORRECT ANSWER-choosing the
agent that releases at *site of inflammation*
caution pH dependent drugs with PPI's, H2RA's, and antacids
Sulfasalazine= - CORRECT ANSWER-sulfapyridine (inactive ingredient) +
mesalamine (5-ASA) (active ingredient)
which part of sulfasalazine causes ADR's? - CORRECT ANSWER-sulfapyridine
IBD Pharm Therapy: Corticosteroids- Clinical Pearls - CORRECT ANSWER-
systemic absorption possible w/ rectal formulations
budesonide is short-term use only
taper pred. treatment
Prednisone/Prednisolone monitoring - CORRECT ANSWER-DEXA bone scan in
patients > 60, osteoporosis risk, using for 3 months, and uses recurrently
IBD Pharm Therapy: AZA/6-MP Clinical Pearls - CORRECT ANSWER-long term
use
can use with other drugs
IBD Pharm Therapy: MTX Contraindications - CORRECT ANSWER-*pregnancy*
pleural efflusions
chronic liver disease
immunodeficiency
leukopenia
