www.stuvia.com/user/BRAINSCAPE1
PHRM 864 prostate cancer Exam
Questions and Answers A+ Graded
(2025)
Describe the hormonal pathogenesis of prostate cancer - CORRECT ANSWER-
testosterone is a growth signal to the prostate
several risk factors associated with prostate cancer are related in increased
testosterone exposure
Describe the androgen receptor pathogenesis of prostate cancer - CORRECT
ANSWER-mutations, overexpression, and changes in AR splicing can all
contribute to prostate cancer
What are the risk factors for prostate cancer? - CORRECT ANSWER-older age
AA race
FH
Describe the pathophysiology of prostate cancer - CORRECT ANSWER-prostate
is located anterior to the rectum and inferior to the bladder
urethra passes through the prostate
prostatic hypertrophy may contribute to sx of prostate cancer
What are the s/sx of prostate cancer? - CORRECT ANSWER-alterations in urinary
habits
impotence
lower extremity edema
wt loss
anemia
, www.stuvia.com/user/BRAINSCAPE1
When do the s/sx of prostate cancer typically occur? - CORRECT ANSWER-
late/advanced stages of prostate cancer
Where do most metastases of prostate cancer occur? - CORRECT ANSWER-bone
Describe how prostate score grading occurs - CORRECT ANSWER-uses gleason
score
scores are assigned to primary and secondary growth patterns then added
together
What do gleason scores 2-4 mean? - CORRECT ANSWER-slow growing
well differentiated
What do gleason scores 8-10 mean? - CORRECT ANSWER-aggressive
poorly differentiated
What does a higher gleason score mean? - CORRECT ANSWER-higher risk of
extracapsular spread
What is a normal PSA? - CORRECT ANSWER-0-4 ng/mL
What PSA value requires evaluation? - CORRECT ANSWER-> 4 ng/mL
What PSA values is highly suspicious for malignancy? - CORRECT ANSWER-> 10
ng/mL
T/F: a PSA velocity > 0.75 ng/ml rise/year is suspicious for malignancy -
CORRECT ANSWER-true
this indicates a rapid increase in growth pattern
What does prostate cancer treatment depend on? - CORRECT ANSWER-stage
grade of dz
age of pt
health status
personal preference
Define m1 prostate cancer - CORRECT ANSWER-metastatic prostate cancer
Define m0CRPC - CORRECT ANSWER-non-metastatic chemical recurrence
prostate canceer
PHRM 864 prostate cancer Exam
Questions and Answers A+ Graded
(2025)
Describe the hormonal pathogenesis of prostate cancer - CORRECT ANSWER-
testosterone is a growth signal to the prostate
several risk factors associated with prostate cancer are related in increased
testosterone exposure
Describe the androgen receptor pathogenesis of prostate cancer - CORRECT
ANSWER-mutations, overexpression, and changes in AR splicing can all
contribute to prostate cancer
What are the risk factors for prostate cancer? - CORRECT ANSWER-older age
AA race
FH
Describe the pathophysiology of prostate cancer - CORRECT ANSWER-prostate
is located anterior to the rectum and inferior to the bladder
urethra passes through the prostate
prostatic hypertrophy may contribute to sx of prostate cancer
What are the s/sx of prostate cancer? - CORRECT ANSWER-alterations in urinary
habits
impotence
lower extremity edema
wt loss
anemia
, www.stuvia.com/user/BRAINSCAPE1
When do the s/sx of prostate cancer typically occur? - CORRECT ANSWER-
late/advanced stages of prostate cancer
Where do most metastases of prostate cancer occur? - CORRECT ANSWER-bone
Describe how prostate score grading occurs - CORRECT ANSWER-uses gleason
score
scores are assigned to primary and secondary growth patterns then added
together
What do gleason scores 2-4 mean? - CORRECT ANSWER-slow growing
well differentiated
What do gleason scores 8-10 mean? - CORRECT ANSWER-aggressive
poorly differentiated
What does a higher gleason score mean? - CORRECT ANSWER-higher risk of
extracapsular spread
What is a normal PSA? - CORRECT ANSWER-0-4 ng/mL
What PSA value requires evaluation? - CORRECT ANSWER-> 4 ng/mL
What PSA values is highly suspicious for malignancy? - CORRECT ANSWER-> 10
ng/mL
T/F: a PSA velocity > 0.75 ng/ml rise/year is suspicious for malignancy -
CORRECT ANSWER-true
this indicates a rapid increase in growth pattern
What does prostate cancer treatment depend on? - CORRECT ANSWER-stage
grade of dz
age of pt
health status
personal preference
Define m1 prostate cancer - CORRECT ANSWER-metastatic prostate cancer
Define m0CRPC - CORRECT ANSWER-non-metastatic chemical recurrence
prostate canceer
