Page 1 of 123
2025/2026 NEW LABORATORY ANIMAL
SCIENCE EXAM PRACTICE QUESTIONS
WITH CORRECT ANSWERS
What are the reasons medications are delivered by gavaging? -- ANSWER--We
deliver medication, food or fluids via gavage when an animal is not eating due
to illness or trauma. We also deliver testing material via gavage in the laboratory
setting; specifically to rats because they cannot vomit.
What are some problems that can occur when oral gavage is administered
improperly? -- ANSWER--If there is too much force exerted when completing a
gavage the esophagus can be punctured or the needle can be accidentally placed
in the trachea.
If the liquid is delivered prior to being fully placed, the animal can aspirate the
fluid.
You are breeding a Brother-Sister mating of 2 B6D2F2 mice. The male is brown
and the female is tan.
What are the correct Genotype possibilities, (future offspring) for these two
mice? -- ANSWER--Male's genotype(s): bbDd, bbDD
, Page 2 of 123
Female's genotype(s): bbdd
How do we sex guinea pigs? -- ANSWER--By examining the genitalia
Guinea Pig Scientific Name -- ANSWER--Cavia Porcellus
Guinea Pig Dental Formula -- ANSWER--2(I1/1, C0/0, P1/1, M3/3)
What teeth in the guinea pig are open rooted? -- ANSWER--All of the teeth
What type of ovulator is the guinea pig? -- ANSWER--Spontaneous
Is the guinea pig covered by the AWA? -- ANSWER--No
What are some uses in research of guinea pigs? -- ANSWER--Cancer
Toxicities
, Page 3 of 123
Behavior Dematologcal
pharmaceuticals
What is pregnancy toxemia? How can it be treated? -- ANSWER--Pregnancy
toxemia is a condition when the mother is in an negative energy balance due to
the pups developing. The mother is not getting enough energy through food and
metabolism to keep up. We treat this with glucose/nutrition supplementation.
How do we sex mice? -- ANSWER--By the anogenital distance, males are 1 ½
X longer than that of females
Guinea Pig IM injection -- ANSWER--Restrain the animal appropriately. Place
thumb of non-dominant hand on the vertebrae and index finger just behind the
most caudal rib. Find the epaxial muscle and lift it against your thumb. With
dominant hand, place syringe perpendicular to the muscle. You will need to
move your hand slightly to look for blood when aspirating.
Mouse SQ Injection -- ANSWER--Restrain the animal appropriately
Place the needle, using a cranial to caudal approach at a 40-45 degree angle into
the scruff between the ears.
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What type of ovulator is a mouse? -- ANSWER--Spontaneous
Is a mouse covered by the AWA? -- ANSWER--No
What is a mouse used in research for? -- ANSWER--Cancer
Toxicities
Pharmaceuticals
Breeding
Behavior
What is Malocclusion? What is the cause? How can it be prevented? --
ANSWER--Overgrown teeth or where the jaws do not match up correctly
Malocclusion is most often caused by the animal not wearing teeth down
adequately due to not having appropriate substrates to chew on Offering
appropriate enrichment to allow the animal to chew.
2025/2026 NEW LABORATORY ANIMAL
SCIENCE EXAM PRACTICE QUESTIONS
WITH CORRECT ANSWERS
What are the reasons medications are delivered by gavaging? -- ANSWER--We
deliver medication, food or fluids via gavage when an animal is not eating due
to illness or trauma. We also deliver testing material via gavage in the laboratory
setting; specifically to rats because they cannot vomit.
What are some problems that can occur when oral gavage is administered
improperly? -- ANSWER--If there is too much force exerted when completing a
gavage the esophagus can be punctured or the needle can be accidentally placed
in the trachea.
If the liquid is delivered prior to being fully placed, the animal can aspirate the
fluid.
You are breeding a Brother-Sister mating of 2 B6D2F2 mice. The male is brown
and the female is tan.
What are the correct Genotype possibilities, (future offspring) for these two
mice? -- ANSWER--Male's genotype(s): bbDd, bbDD
, Page 2 of 123
Female's genotype(s): bbdd
How do we sex guinea pigs? -- ANSWER--By examining the genitalia
Guinea Pig Scientific Name -- ANSWER--Cavia Porcellus
Guinea Pig Dental Formula -- ANSWER--2(I1/1, C0/0, P1/1, M3/3)
What teeth in the guinea pig are open rooted? -- ANSWER--All of the teeth
What type of ovulator is the guinea pig? -- ANSWER--Spontaneous
Is the guinea pig covered by the AWA? -- ANSWER--No
What are some uses in research of guinea pigs? -- ANSWER--Cancer
Toxicities
, Page 3 of 123
Behavior Dematologcal
pharmaceuticals
What is pregnancy toxemia? How can it be treated? -- ANSWER--Pregnancy
toxemia is a condition when the mother is in an negative energy balance due to
the pups developing. The mother is not getting enough energy through food and
metabolism to keep up. We treat this with glucose/nutrition supplementation.
How do we sex mice? -- ANSWER--By the anogenital distance, males are 1 ½
X longer than that of females
Guinea Pig IM injection -- ANSWER--Restrain the animal appropriately. Place
thumb of non-dominant hand on the vertebrae and index finger just behind the
most caudal rib. Find the epaxial muscle and lift it against your thumb. With
dominant hand, place syringe perpendicular to the muscle. You will need to
move your hand slightly to look for blood when aspirating.
Mouse SQ Injection -- ANSWER--Restrain the animal appropriately
Place the needle, using a cranial to caudal approach at a 40-45 degree angle into
the scruff between the ears.
, Page 4 of 123
What type of ovulator is a mouse? -- ANSWER--Spontaneous
Is a mouse covered by the AWA? -- ANSWER--No
What is a mouse used in research for? -- ANSWER--Cancer
Toxicities
Pharmaceuticals
Breeding
Behavior
What is Malocclusion? What is the cause? How can it be prevented? --
ANSWER--Overgrown teeth or where the jaws do not match up correctly
Malocclusion is most often caused by the animal not wearing teeth down
adequately due to not having appropriate substrates to chew on Offering
appropriate enrichment to allow the animal to chew.
