UC NURS8022 EXAM 2 HEMATOLOGY
HEMATOPOIESIS - answer THE PROCESS OF BLOOD CELL PRODUCTION
WHERE ARE RED BLOOD CELLS MADE? - answer ADULTS: BONE MARROW
CHILDREN: LIVER AND/OR SPLEEN
WHAT ARE THE TWO STAGES OF HEMATOPOIESIS? – answer MITOSIS
(PROLIFERATION)
MATURATION (DIFFERENTIATION)
WHERE IS ADULT ACTIVE BONE MARROW FOUND? – answer PELVIC BONES
VERTEBRAE
CRANIUM
MANDIBLE
STERNUM
RIBS
HUMERUS
FEMUR
HEMATOPOIESIS PROCESS – answer STEM CELLS-->DIFFERENTIATION--
>KEEPS SOME AS STEM CELLS-->MYELOID/PROGENITOR CELLS-->RBC'S
DO INFANTS HAVE INCREASED OR DECREASED WBC/RBC COUNTS AT BIRTH? -
answerELEVATED
WHAT IS ANOTHER NAME FOR BONE MARROW? - answerMYELOID TISSUE
WHAT HORMONE STIMULATES ERYTHROCYTE PRODUCTION? -
answerERYTHROPOIETIN
WHAT IS ERYTHROPOIESIS? - answerDEVELOPMENT OF RBC'S
ERYTHROCYTES DERIVED FROM? - answerERYTHROBLASTS
WHAT CONVERTS YELLOW BONE MARROW TO HEMATOPOIETIC RED
MARROW? - answerERYTHROPOIETIN
WHERE IS ERYTHROPOIETIN PRODUCED? - answerPERTIBULAR CELLS OF
KIDNEY
WHAT FEEDBACK LOOP IS USED IN ERYTHROPOIESIS? - answerNEGATIVE
FEEDBACK LOOP
,WHEN IS ERYTHROPOIETIN RELEASED? - answerIN RESPONSE TO LOW RENAL
OXYGENATION
HOW FAST CAN ERYTHROPOIETIN INCREASE RBC PRODUCTION? - answer24
HOURS
INCREASED RBC NUMBER IN 5 DAYS
WHAT IS ERYTHROPOIETIN LIFE SPAN? - answer4-12 HOURS
ERYTHROPOIETIN IS ALWAYS PRESENT WHERE? - answerIN THE PLASMA
WHAT TYPES OF PATIENTS ARE GIVEN ERYTHROPOIETIN? - answerDIALYSIS
AND CHEMO PATIENTS
THESE PT'S ARE ANEMIC, SO GIVEN EPO TO STIMULATE ERYTHROPOIESIS
GIVEN SEVERAL TIMES PER WEEK
GOAL TO INCREASE HEMATOCRIT TO 33%
WHAT IS THE LAST IMMATURE FORM OF THE ERYTHROBLAST? -
answerRETICULOCYTE
MEASURING A RETICULOCYTE COUNT IS A GOOD INDICATOR OF WHAT? -
answerERYTHROPOIESIS (NEW RBC'S BEING MADE)
WHAT IS HEMOGLOBIN? - answerOXYGEN CARRYING PORTION OF THE RBC'S
NORMAL HEMOGLOBIN - answer13-16GM/DL
WHAT MOLECULE IS ATTACHED TO HEME ON HEMOGLOBIN? - answerOXYGEN
EACH HEMOGLOBIN MOLECULE HAS HOW MANY GLOBIN CHAINS? - answer2
EACH HEMOGLOBIN MOLECULE HAS HOW MANY COMPLEXES OF IRON AND
HEME? - answer4
WHERE IS HEME SYNTHESIZED? - answerMITOCHONDRIA
HEME CARRIES HOW MANY OXYGEN MOLECULES? - answer1
EVERY MOLECULE OF HEMOGLOBIN CARRIES HOW MANY OXYGEN? - answer4
WHAT IS GLOBIN? - answerPROTEIN THAT CONTAINS HEME
MOST COMMON GLOBIN CHAIN? - answerHGB-A
, 2 ALPHA CHAINS
2 BETA CHAINS
WHAT DO RBC'S USE FOR ENERGY? - answerGLYCOLYSIS
DO RBC'S HAVE MITOCHONDRIA? - answerNO
THUS, NO ATP
TRANSFERRIN TURNS TO WHAT? - answerFERRITIN
G6PD DOES WHAT? - answerPROTECTS RBC'S AGAINST OXIDATIVE STRESS
WHAT IS ANEMIA? - answerREDUCTION IN THE TOTAL NUMBER OF
ERYTHROCYTES IN THE CIRCULATING BLOOD
ANISOCYTOSIS? - answerRBC'S ARE VARIOUS SIZES
POIKLOCYTOSIS? - answerRBC'S ARE VARIOUS SHAPES
IRON-DEFICIENCY ANEMIA PATHO - answerINADEQUATE DIETARY INTAKE
BLOOD LOSS
PARASITE INFECTIONS
MENORRHAGIA*
GI BLEED*
IRON-DEFICIENCY CLINICAL MANIFESTATIONS - answerCOGNITIVE IMPAIRMENT
IN CHILDREN
NO SYMPTOMS MILD ANEMIA
DYSNPLEA
PICA* (PREGNANT LADIES)
LAB VALUES FOR IRON DEFICIENCY ANEMIA - answerLOW FERRITIN (MOST
SENSITIVE TEST FOR IDA)
LOW SERUM IRON
HIGH TIBC****
IF THERE IS NOT ENOUGH IRON TO BIND TO TRANSFERRIN, WILL THE TIBC BE
HIGH OR LOW? - answerHIGH TIBC
SIDEROBLASTIC ANEMIA PATHO - answerPROBLEM WITH HEME
DEFECT IN MITOCHONDRIAL HEME SYNTHESIS*
DYSFUNCTIONAL HEMOGLOBIN SYNTHESIS*
SIDEROBLASTIC ANEMIA CLINICAL MANIFESTATIONS - answerIRON OVERLOAD
HEMATOPOIESIS - answer THE PROCESS OF BLOOD CELL PRODUCTION
WHERE ARE RED BLOOD CELLS MADE? - answer ADULTS: BONE MARROW
CHILDREN: LIVER AND/OR SPLEEN
WHAT ARE THE TWO STAGES OF HEMATOPOIESIS? – answer MITOSIS
(PROLIFERATION)
MATURATION (DIFFERENTIATION)
WHERE IS ADULT ACTIVE BONE MARROW FOUND? – answer PELVIC BONES
VERTEBRAE
CRANIUM
MANDIBLE
STERNUM
RIBS
HUMERUS
FEMUR
HEMATOPOIESIS PROCESS – answer STEM CELLS-->DIFFERENTIATION--
>KEEPS SOME AS STEM CELLS-->MYELOID/PROGENITOR CELLS-->RBC'S
DO INFANTS HAVE INCREASED OR DECREASED WBC/RBC COUNTS AT BIRTH? -
answerELEVATED
WHAT IS ANOTHER NAME FOR BONE MARROW? - answerMYELOID TISSUE
WHAT HORMONE STIMULATES ERYTHROCYTE PRODUCTION? -
answerERYTHROPOIETIN
WHAT IS ERYTHROPOIESIS? - answerDEVELOPMENT OF RBC'S
ERYTHROCYTES DERIVED FROM? - answerERYTHROBLASTS
WHAT CONVERTS YELLOW BONE MARROW TO HEMATOPOIETIC RED
MARROW? - answerERYTHROPOIETIN
WHERE IS ERYTHROPOIETIN PRODUCED? - answerPERTIBULAR CELLS OF
KIDNEY
WHAT FEEDBACK LOOP IS USED IN ERYTHROPOIESIS? - answerNEGATIVE
FEEDBACK LOOP
,WHEN IS ERYTHROPOIETIN RELEASED? - answerIN RESPONSE TO LOW RENAL
OXYGENATION
HOW FAST CAN ERYTHROPOIETIN INCREASE RBC PRODUCTION? - answer24
HOURS
INCREASED RBC NUMBER IN 5 DAYS
WHAT IS ERYTHROPOIETIN LIFE SPAN? - answer4-12 HOURS
ERYTHROPOIETIN IS ALWAYS PRESENT WHERE? - answerIN THE PLASMA
WHAT TYPES OF PATIENTS ARE GIVEN ERYTHROPOIETIN? - answerDIALYSIS
AND CHEMO PATIENTS
THESE PT'S ARE ANEMIC, SO GIVEN EPO TO STIMULATE ERYTHROPOIESIS
GIVEN SEVERAL TIMES PER WEEK
GOAL TO INCREASE HEMATOCRIT TO 33%
WHAT IS THE LAST IMMATURE FORM OF THE ERYTHROBLAST? -
answerRETICULOCYTE
MEASURING A RETICULOCYTE COUNT IS A GOOD INDICATOR OF WHAT? -
answerERYTHROPOIESIS (NEW RBC'S BEING MADE)
WHAT IS HEMOGLOBIN? - answerOXYGEN CARRYING PORTION OF THE RBC'S
NORMAL HEMOGLOBIN - answer13-16GM/DL
WHAT MOLECULE IS ATTACHED TO HEME ON HEMOGLOBIN? - answerOXYGEN
EACH HEMOGLOBIN MOLECULE HAS HOW MANY GLOBIN CHAINS? - answer2
EACH HEMOGLOBIN MOLECULE HAS HOW MANY COMPLEXES OF IRON AND
HEME? - answer4
WHERE IS HEME SYNTHESIZED? - answerMITOCHONDRIA
HEME CARRIES HOW MANY OXYGEN MOLECULES? - answer1
EVERY MOLECULE OF HEMOGLOBIN CARRIES HOW MANY OXYGEN? - answer4
WHAT IS GLOBIN? - answerPROTEIN THAT CONTAINS HEME
MOST COMMON GLOBIN CHAIN? - answerHGB-A
, 2 ALPHA CHAINS
2 BETA CHAINS
WHAT DO RBC'S USE FOR ENERGY? - answerGLYCOLYSIS
DO RBC'S HAVE MITOCHONDRIA? - answerNO
THUS, NO ATP
TRANSFERRIN TURNS TO WHAT? - answerFERRITIN
G6PD DOES WHAT? - answerPROTECTS RBC'S AGAINST OXIDATIVE STRESS
WHAT IS ANEMIA? - answerREDUCTION IN THE TOTAL NUMBER OF
ERYTHROCYTES IN THE CIRCULATING BLOOD
ANISOCYTOSIS? - answerRBC'S ARE VARIOUS SIZES
POIKLOCYTOSIS? - answerRBC'S ARE VARIOUS SHAPES
IRON-DEFICIENCY ANEMIA PATHO - answerINADEQUATE DIETARY INTAKE
BLOOD LOSS
PARASITE INFECTIONS
MENORRHAGIA*
GI BLEED*
IRON-DEFICIENCY CLINICAL MANIFESTATIONS - answerCOGNITIVE IMPAIRMENT
IN CHILDREN
NO SYMPTOMS MILD ANEMIA
DYSNPLEA
PICA* (PREGNANT LADIES)
LAB VALUES FOR IRON DEFICIENCY ANEMIA - answerLOW FERRITIN (MOST
SENSITIVE TEST FOR IDA)
LOW SERUM IRON
HIGH TIBC****
IF THERE IS NOT ENOUGH IRON TO BIND TO TRANSFERRIN, WILL THE TIBC BE
HIGH OR LOW? - answerHIGH TIBC
SIDEROBLASTIC ANEMIA PATHO - answerPROBLEM WITH HEME
DEFECT IN MITOCHONDRIAL HEME SYNTHESIS*
DYSFUNCTIONAL HEMOGLOBIN SYNTHESIS*
SIDEROBLASTIC ANEMIA CLINICAL MANIFESTATIONS - answerIRON OVERLOAD
