PHM 550 RSV, Meningococcal, Tdap & Varicella | Updated, Complete Solutions

PHM 550 RSV, Meningococcal, Tdap & Varicella | Updated, Complete Solutions What is RSV? A common respiratory virus that usually causes mild, cold-like symptoms How is RSV spread? Person to person via respiratory droplets What is the mean incubation period for RSV? 4 to 6 days How do infected adults typically present with RSV? Mild to no symptoms What type of symptoms are commonly seen in adults with RSV? Upper respiratory symptoms What severe complication can RSV cause in some adults? Lower respiratory infection, such as pneumonia Which age group is most likely to experience severe RSV cases? Infants and young children What adult population is at higher risk for severe RSV? Adults with chronic medical conditions How does age affect RSV severity in older adults? Older adults, especially 65 years and older, are at increased risk Why are premature infants at higher risk for severe RSV? They have underdeveloped lungs/immune systems, making them more vulnerable Which infants are particularly at risk for severe RSV? Infants 6 months and younger What conditions increase RSV risk in children under 2 years? Chronic lung disease or congenital heart disease How does immune status affect RSV severity in children? Children with weakened immune systems are more susceptible What chronic conditions increase RSV risk in adults? Chronic heart or lung disease How does immune suppression affect RSV risk in adults? Adults with weakened immune systems are more likely to develop severe illness What is Nirsevimab-alip (Beyfortus)? A long-acting monoclonal antibody used for passive immunization against RSV How is Beyfortus administered? Intramuscular injection How long does passive immunization from Beyfortus last? Up to 150 days What dose of Beyfortus should infants under 8 months receive during their first RSV season? One dose - 50 mg for infants 5 kg, 100 mg for infants /= 5 kg Which children qualify for RSV immunization during their second season? 8-19 months who are at increased risk of severe RSV disease What is the recommended dose for high-risk children entering their second RSV season? One dose of 200 mg What is Clesrovimab (Enflonsia)? A long-acting monoclonal antibody used for passive immunization against RSV Who is Clesrovimab indicated for? All neonates or infants born during or entering their first RSV season What is the dosage and administration method for Clesrovimab? 105 mg/0.7 mL administered intramuscularly, regardless of weight How long does Clesrovimab provide protection against RSV? Approximately 150 days What is the shared recommendation for Clesrovimab and Nirsevimab? Both are recommended for infants under 8 months of age born during or entering their first RSV season When is RSV immunization typically administered in the U.S.? Between October and March Under what conditions should infants receive Clesrovimab or Nirsevimab? If the mother did not receive RSV vaccine during pregnancy If the mother's RSV vaccination status is unknown If the infant was born less than 14 days after maternal RSV vaccination What RSV product is recommended for infants and young children? Infant RSV antibody only What RSV vaccine is recommended during pregnancy? Abrysvo (Pfizer) only What RSV vaccines are approved for older adults? Abrysvo (Pfizer), Arexvy (GSK), and mResvia (Moderna) What high-risk groups were shown to benefit from RSV vaccination? Adults aged 75 years or older Adults with immunocompromising conditions Adults with underlying cardiopulmonary disease Who is universally recommended to receive the RSV vaccine? All adults 75 years and older should receive a single dose of the RSV vaccine What is the recommendation for adults aged 50-74? Adults 50-74 years old who are at increased risk of severe RSV disease should receive a single dose of the RSV vaccine Is RSV vaccination a recurring or one-time dose? Single lifetime dose Should adults 50-74 without risk factors receive the RSV vaccine? No When should RSV vaccination ideally occur? Before the onset of increased RSV activity—late summer or early fall is optimal Can older adults receive RSV vaccination year-round? Yes, using shared clinical decision-making, older adults may be vaccinated year-round Is coadministration of RSV vaccine with other adult vaccines allowed? Yes Which vaccines can be coadministered with RSV vaccine? Flu, COVID-19, pneumococcal, Td/Tdap, and recombinant zoster vaccine What do Shingrix and Arexvy have in common? Both contain the same adjuvant, which may affect reactogenicity when given together What is the name of the maternal RSV vaccine by Pfizer? RSVPreF, brand name Abrysvo What is the recommended gestational age for RSVPreF administration? 32 through 36 weeks of pregnancy What is the optimal season for RSV vaccination in most of the continental U.S.? September through January What are the indications for Abrysvo? Pregnancy: 32-36 weeks gestation Adults: 50 years and older with increased risk of severe RSV What is the dosage and route for Abrysvo? 0.5 mL intramuscular (IM) single dose after reconstitution How long is Abrysvo usable after reconstitution? Must be used within 4 hours What is the indication for Arexvy? Prevention of RSV in patients 50 years and older What is the dosage and route for Arexvy? 0.5 mL intramuscular (IM) single dose What is the indication for MResvia? -Adults 60 years and older -Adults 18-59 years at increased risk for lower respiratory tract disease (LRTD) caused by RSV What is the dosage and route for MResvia? 0.5 mL intramuscular (IM) single dose What causes meningococcal disease? Neisseria meningitidis What are the two available MenACWY vaccines? Menveo (GSK) and MenQuadfi (Sanofi Pasteur) What is the dosage and route for both Menveo and MenQuadfi? 0.5 mL intramuscular (IM) injection What is Menveo's vial formats? -One Vial: No reconstitution (ages 10-55 years) -Two Vial: Requires reconstitution What is Menveo's primary vaccination schedule for infants? 2 months old: 4 doses at 2, 4, 6, and 12 months 7-23 months: 2 doses, second dose in 2nd year, ≥3 months apart What is Menveo's schedule for ages 2-55 years? Single dose What is MenQuadfi's primary vaccination schedule? Single dose for individuals ≥2 years At what age should adolescents receive their first dose of MCV4? 11-12 years When is the booster dose of MCV4 recommended? At 16, if first dose was given before 16th birthday Is the booster needed if the first dose was given after 16? No, only one dose needed Is MCV4 routinely recommended after age 19? No, not routinely recommended Which adults should receive MCV4 due to medical conditions? Those with persistent complement deficiency, asplenia, or HIV What is the dosing schedule for high-risk adults? 2 doses, given at least 8 weeks apart When should children aged 2-6 at continued risk receive an additional MCV4 dose? 3 years after the first dose What is the revaccination schedule for individuals who completed the 2-dose MCV4 series and remain at risk? Every 5 years after the last dose What is the revaccination schedule for those with complement deficiency or asplenia? 1 dose of MCV4 every 5 years after completing the 2-dose primary series What are the two available MenB vaccines? -Trumenba (Pfizer) -Bexsero (Novartis) What is the dose scheduling for Trumenba (Pfizer)? -3-dose series: 0, 1-2, and 6 months -2-dose series: 0 and 6 months 0.5 mL IM What is the dosing schedule for Bexsero (Novartis)? 2-dose series: 0, 1-6 months 0.5 mL IM