Immunology BOC Questions with answers

Immunology BOC Questions with answers |\ |\ |\ |\




The air temperature throughout the serology laboratory is 20°C.
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How will this affect VDRL and RPR test results?
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A.no effect—the acceptable test range is 20-24°C
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B.weaken reactions so that false-negatives occur
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C.strengthen reactions so that positive titers appear elevated
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D.increase the number of false-positives from spontaneous
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clumping
B.weaken reactions so that false-negatives occur
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The immunoglobulin class typically found to be present in saliva,
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tears and other secretions is:
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A.IgG
B.IgA
C.IgM
D.IgD
B.IgA
A 16-year-old boy with infectious mononucleosis has a cold
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agglutinin titer of 1:2000. An important consideration of this
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antibody's clinical relevance is the: |\ |\ |\ |\




A.thermal range |\




B.titer at 4°C |\ |\




C.specificity
D.light chain type |\ |\

,A.thermal range (It is important to determine the thermal range
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of reactivity, because cold antibodies are most likely to cause
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disease if they react with red blood cells at temperatures from
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30-32°C.)
Antibodies to which of the following immunoglobulins is known to
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have produced anaphylactic reactions following blood
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transfusion?
A.IgA
B.IgD
C.IgE
D.IgG
A.IgA
The serum hemolytic complement level (CH50):
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A.is a measure of total complement activity
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B.provides the same information as a serum factor B level
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C.is detectable when any component of the classical system is
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congenitally absent |\




D.can be calculated from the serum concentrations of the
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individual components |\




A.is a measure of total complement activity
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Delayed hypersensitivity may be induced by:
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A.contact sensitivity to inorganic chemicals
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B.transfusion reaction |\




C.anaphylactic reaction |\




D.bacterial septicemia |\




A.contact sensitivity to inorganic chemicals
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,The disappearance of HBsAg and HBeAg, the persistence of anti-
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HBc, the appearance of anti-HBs, and often of anti-HBe indicate:
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A.early acute HBV hepatitis |\ |\ |\




B.early convalescent phase HBV hepatitis
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C.recovery phase of acute HBV hepatitis |\ |\ |\ |\ |\




D.carrier state of acute HBV hepatitis
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C.recovery phase of acute HBV hepatitis (Anti-HBs and anti-HBe
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are associated with recovery and development of immunity in
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hepatitis B, while HBsAg and HBeAg are antigens from HBV that
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are present during the infectious stages of disease.)
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Immunoediting describes the theory that our immune system |\ |\ |\ |\ |\ |\ |\ |\


prevents many cancers. Its three phases (called the 3 ‘e's)
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include all of the following EXCEPT:
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A.efficiency
B.equilibrium
C.escape
D.elimination
A.efficiency
IgM antibodies are frequently hemolytic because of:
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A.their dimeric structure |\ |\




B.the molecule's 5 antigen-binding sites
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C.their sedimentation coefficient of 7-15 S
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D.their efficient ability to fix complement
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D.their efficient ability to fix complement
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Skin, lactic acid in sweat, pH balance, mucous, and the motion of
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cilia represent which type of immunity?
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, A.natural
B.acquired
C.adaptive
D.auto
A.natural
The key structural difference that distinguishes immunoglobulin
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subclasses is the: |\ |\




A.number of domains |\ |\




B.stereometry of the hypervariable region |\ |\ |\ |\




C.the sequence of the constant regions
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D.covalent linkage of the light chains |\ |\ |\ |\ |\




C.the sequence of the constant regions (Immunoglobulin
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subclasses differ from each other in their Fc regions; this is the
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reason that the different classes have different biological
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function. The Fc region is the region that is crystallizable after
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papain cleavage. It varies in sequence in the different classes of
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immunoglobulin.)
Incompatibility by which of the following procedures is an |\ |\ |\ |\ |\ |\ |\ |\ |\


absolute contraindication to allotransplantation?
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A.MLC (mixed lymphocyte culture)
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B.HLA typing |\




C.Rh typing|\




D.ABO grouping |\




D.ABO grouping |\




A suspected anthrax lesion was submitted to the lab for
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preparation and testing. The test of choice to interrogate this
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sample is: |\