1|Page
PHARM 615 EXAM 3 MARYVILLE Study Guide Questions and
Answers with 100% Complete Solutions UPDATED!!!
1. What vitamin will decrease peripheral neuropathy? -
ANSWER The use of pyridoxine or Vitamin B6 can be
administered for patients who are on isoniazid therapy for
tuberculosis
2. What lab values should be assessed when administering
valacyclovir? - ANSWER Some antiviral drugs that are effective
in treating herpes including acyclovir (first discovered and also
available in generic form), valacyclovir (also available in generic
form), famcyclovir, and pencyclovir. 10% of Valacyclovir is
metabolized by the liver, while 90% is metabolized by the
kidney. Thus, Blood Urea Nitrogen (BUN) and creatinine levels
should be assessed prior to administering Valacyclovir. Food
slows down the absorption, but overall, it does not affect the
absorption of valcyclovir. Valacyclovir should be taken with a full
glass of water and the patient should increase the water intake.
3. When should oseltamivir phosphate be prescribed? -
ANSWER Oseltamivit, marketed under the trade name Tamiflu,
is an antiviral medication used to treat influenza A and influenza
,2|Page
B and to prevent flu after exposure. The medications taken
orally. The CDC recommends use of oseltamivir for people who
have complications or are at high risk for complications who
percent within 48 hours of the first symptoms infection.
4. For what is rifampin prescribed? - ANSWER Rifampin is an
antibiotic used to treat a number of bacterial infections. This
includes tuberculosis, leprosy, and legionella among others. It
often is used with other antibiotics. It is also used to prevent
haemophilus influenzae type b and meningococcal disease in
those who have been exposed, such as people who live in close
quarters like soldiers and college students. Before treating
someone for a long period of time testing the liver function and
blood counts are recommended. It is available by mouth and IV.
It is also part of the recommended treatment of active
tuberculosis during pregnancy, even though its safety and
pregnancy is not known. Rifampin is of the erythromycin group
of antibiotics and works. by stopping production of bacterial
RNA
5. What are the adverse effects of isoniazid (INH)? - ANSWER
The adverse effects of Isoniazid that is an antibiotic used a first
line agent for the prevention and treatment of tuberculosis
include; Peripheral neuropathy which is involved in patients
taking isoniazid and it occurs in about 2% of patients taking 5
mg/kg/d, and the prevalence is higher for patients taking higher
, 3|Page
doses, up to about 44% for patients taking 16 mg/kg/d. The
symptoms of peripheral neuropathy include symmetrical
numbness and tingling in the extremities. The patients who are
predisposed to this adverse reaction include people who are
malnourished, slow acetylators, pregnant women, older adults,
diabetics, and patients with chronic liver disease, including
alcoholics. Peripheral neuropathy with the use of isonazid can
be prevented with the use of Pyridoxine (Vitamin B6) and is
recommended for patients in the at-risk groups. The
recommended prophylactic doses range from 10 to 50 mg daily,
while the treatment of established neuropathy requires 50 to
200 mg daily.
Other adverse effects include; elevated serum transaminases
(AST/ALT; liver enzymes) observed in 10% to 20% of patients
taking isoniazid occurring usually in the first 3 months of
therapy that is asymptomatic, and will return to normal with
continued isoniazid therapy. However, in a small portion of
patients (0.4%), this condition may progress to hepatic failure or
necrosis, and progressive liver damage that increases with age
and the risk is increased by concurrent alcohol use, and
increased 4-fold with concurrent rifampin administration. In
addition, some adverse reactions associated with isoniazid
include blood dyscrasias, metabolic acidosis, drug fever, and
gynecomastia.
PHARM 615 EXAM 3 MARYVILLE Study Guide Questions and
Answers with 100% Complete Solutions UPDATED!!!
1. What vitamin will decrease peripheral neuropathy? -
ANSWER The use of pyridoxine or Vitamin B6 can be
administered for patients who are on isoniazid therapy for
tuberculosis
2. What lab values should be assessed when administering
valacyclovir? - ANSWER Some antiviral drugs that are effective
in treating herpes including acyclovir (first discovered and also
available in generic form), valacyclovir (also available in generic
form), famcyclovir, and pencyclovir. 10% of Valacyclovir is
metabolized by the liver, while 90% is metabolized by the
kidney. Thus, Blood Urea Nitrogen (BUN) and creatinine levels
should be assessed prior to administering Valacyclovir. Food
slows down the absorption, but overall, it does not affect the
absorption of valcyclovir. Valacyclovir should be taken with a full
glass of water and the patient should increase the water intake.
3. When should oseltamivir phosphate be prescribed? -
ANSWER Oseltamivit, marketed under the trade name Tamiflu,
is an antiviral medication used to treat influenza A and influenza
,2|Page
B and to prevent flu after exposure. The medications taken
orally. The CDC recommends use of oseltamivir for people who
have complications or are at high risk for complications who
percent within 48 hours of the first symptoms infection.
4. For what is rifampin prescribed? - ANSWER Rifampin is an
antibiotic used to treat a number of bacterial infections. This
includes tuberculosis, leprosy, and legionella among others. It
often is used with other antibiotics. It is also used to prevent
haemophilus influenzae type b and meningococcal disease in
those who have been exposed, such as people who live in close
quarters like soldiers and college students. Before treating
someone for a long period of time testing the liver function and
blood counts are recommended. It is available by mouth and IV.
It is also part of the recommended treatment of active
tuberculosis during pregnancy, even though its safety and
pregnancy is not known. Rifampin is of the erythromycin group
of antibiotics and works. by stopping production of bacterial
RNA
5. What are the adverse effects of isoniazid (INH)? - ANSWER
The adverse effects of Isoniazid that is an antibiotic used a first
line agent for the prevention and treatment of tuberculosis
include; Peripheral neuropathy which is involved in patients
taking isoniazid and it occurs in about 2% of patients taking 5
mg/kg/d, and the prevalence is higher for patients taking higher
, 3|Page
doses, up to about 44% for patients taking 16 mg/kg/d. The
symptoms of peripheral neuropathy include symmetrical
numbness and tingling in the extremities. The patients who are
predisposed to this adverse reaction include people who are
malnourished, slow acetylators, pregnant women, older adults,
diabetics, and patients with chronic liver disease, including
alcoholics. Peripheral neuropathy with the use of isonazid can
be prevented with the use of Pyridoxine (Vitamin B6) and is
recommended for patients in the at-risk groups. The
recommended prophylactic doses range from 10 to 50 mg daily,
while the treatment of established neuropathy requires 50 to
200 mg daily.
Other adverse effects include; elevated serum transaminases
(AST/ALT; liver enzymes) observed in 10% to 20% of patients
taking isoniazid occurring usually in the first 3 months of
therapy that is asymptomatic, and will return to normal with
continued isoniazid therapy. However, in a small portion of
patients (0.4%), this condition may progress to hepatic failure or
necrosis, and progressive liver damage that increases with age
and the risk is increased by concurrent alcohol use, and
increased 4-fold with concurrent rifampin administration. In
addition, some adverse reactions associated with isoniazid
include blood dyscrasias, metabolic acidosis, drug fever, and
gynecomastia.
