HEMATOLOGY MMSC423 EXAM 1 STUDY GUIDE
QUESTIONS AND ANSWERS NEW MODIFIED
TESTED AND APPROVED
Which of the following is a receptor for fibrinogen on the platelet membrane?
GPIVb/IIIa
GPVa/Xb
GPIIb/IIIa
GPIb/IIIb -- ANSWER--GPIIb/IIIa
Tissue plasminogen activator converts plasminogen to plasmin on the surface
of:
fibrin clot thrombin urokinase fibrinogen -- ANSWER--fibrin clot
ADP is secreted from the:
dense granules beta granules delta granules alpha granules -- ANSWER--dense
granules
Factor III is known as prothrombin time calcium christmas factor tissue factor
-- ANSWER--tissue factor Which of the following is true regarding the plasma
coagulation zymogens?
- are haptens that induce peptide binding to make larger active molecules
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,- activation normally occurs throughout the tissues of the body when
vascular injury occurs
- serine proteases that form complexes to activate other zymogens to
ultimately generate thrombin
- circulate normally in their active form -- ANSWER--serine proteases that
form complexes to activate other zymogens to ultimately generate thrombin
What reaction is essential in the production of vitamin K dependent coagulation
factors?
reduction of tryptophan oxidation of valine gamma carboxylation of
glutamic acid dehydrogenation of leucine -- ANSWER--gamma carboxylation
of glutamic acid
Another name for Factor X is:
Stuart-Prower
Christmas Factor
Fitzgerald Factor
Hagemen Factor -- ANSWER--Stuart-Prower
What happens to the fibrin monomers created when thrombin cleaves
fibrinopeptides A and B from fibrinogen?
digested quickly by tissue plasminogen activator converted to plasminogen
immediately inactivated to prevent excess clotting polymerized and are
stabilized by FXIIIa -- ANSWER--polymerized and are stabilized by FXIIIa
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,Alpha granules are located in which zone of the platelet?
organelle peripheral open canalicular system sol-gel -- ANSWER--
organelle
All of the following are functions of thrombin except:
activates plasminogen activates FV and FVIII initiates platelet aggregation
activates FXII -- ANSWER--activates plasminogen
Factor IX is known as: Fitzgerald factor thrombin
Christmas Factor antihemophilic factor -- ANSWER--christmas factor
Factor XIII is known as: Stuart-Prower Factor fibrin stabilizing factor
antihemophilic factor labile factor -- ANSWER--fibrin stabilizing factor
Which of the following are components of the contact group of factors?
calcium and IX
XII and prekallikrein VIII and vWF fibrinogen and thrombin -- ANSWER--
XII and prekallikrein
Factor XI is known as: Stuart-Prower factor plasma thromboplastin antecedent
Labile factor
Hageman Factor -- ANSWER--plasma thromboplastin antecedent
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, This fragment of fibrinolysis is representative of plasmin's action on insoluble
fibrin fragment X fragment Y fragment D
D-dimer -- ANSWER--D-dimer
What is the primary role of vWF?
mediate platelet secretion mediate platelet aggregation mediate platelet
adhesion activator of protein C -- ANSWER--mediate platelet adhesion
What constituent of the peripheral zone contains glycoproteins responsible for
blood group specificity (ABO), tissue compatibility, and platelet antigenicity?
actin open canalicular system Golgi complex glycocalyx -- ANSWER--
glycocalyx
A tube of anticoagulated blood was centrifuged. After centrifugation which of
the following describes the correct sequence of layers from top to bottom of the
tube?
buffy coat, plasma, red blood cells buffy coat, red blood cells, plasma plasma,
buffy coat, red blood cells red blood cells, buffy coat, plasma -- ANSWER--
plasma, buffy coat, red blood cells
Factor VII is known as:
fibrinogen stable factor christmas factor labile factor -- ANSWER--stable factor
Tissue Factor Pathway Inhibitor inactivates which factor?
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QUESTIONS AND ANSWERS NEW MODIFIED
TESTED AND APPROVED
Which of the following is a receptor for fibrinogen on the platelet membrane?
GPIVb/IIIa
GPVa/Xb
GPIIb/IIIa
GPIb/IIIb -- ANSWER--GPIIb/IIIa
Tissue plasminogen activator converts plasminogen to plasmin on the surface
of:
fibrin clot thrombin urokinase fibrinogen -- ANSWER--fibrin clot
ADP is secreted from the:
dense granules beta granules delta granules alpha granules -- ANSWER--dense
granules
Factor III is known as prothrombin time calcium christmas factor tissue factor
-- ANSWER--tissue factor Which of the following is true regarding the plasma
coagulation zymogens?
- are haptens that induce peptide binding to make larger active molecules
Page 1 of 35
,- activation normally occurs throughout the tissues of the body when
vascular injury occurs
- serine proteases that form complexes to activate other zymogens to
ultimately generate thrombin
- circulate normally in their active form -- ANSWER--serine proteases that
form complexes to activate other zymogens to ultimately generate thrombin
What reaction is essential in the production of vitamin K dependent coagulation
factors?
reduction of tryptophan oxidation of valine gamma carboxylation of
glutamic acid dehydrogenation of leucine -- ANSWER--gamma carboxylation
of glutamic acid
Another name for Factor X is:
Stuart-Prower
Christmas Factor
Fitzgerald Factor
Hagemen Factor -- ANSWER--Stuart-Prower
What happens to the fibrin monomers created when thrombin cleaves
fibrinopeptides A and B from fibrinogen?
digested quickly by tissue plasminogen activator converted to plasminogen
immediately inactivated to prevent excess clotting polymerized and are
stabilized by FXIIIa -- ANSWER--polymerized and are stabilized by FXIIIa
Page 2 of 35
,Alpha granules are located in which zone of the platelet?
organelle peripheral open canalicular system sol-gel -- ANSWER--
organelle
All of the following are functions of thrombin except:
activates plasminogen activates FV and FVIII initiates platelet aggregation
activates FXII -- ANSWER--activates plasminogen
Factor IX is known as: Fitzgerald factor thrombin
Christmas Factor antihemophilic factor -- ANSWER--christmas factor
Factor XIII is known as: Stuart-Prower Factor fibrin stabilizing factor
antihemophilic factor labile factor -- ANSWER--fibrin stabilizing factor
Which of the following are components of the contact group of factors?
calcium and IX
XII and prekallikrein VIII and vWF fibrinogen and thrombin -- ANSWER--
XII and prekallikrein
Factor XI is known as: Stuart-Prower factor plasma thromboplastin antecedent
Labile factor
Hageman Factor -- ANSWER--plasma thromboplastin antecedent
Page 3 of 35
, This fragment of fibrinolysis is representative of plasmin's action on insoluble
fibrin fragment X fragment Y fragment D
D-dimer -- ANSWER--D-dimer
What is the primary role of vWF?
mediate platelet secretion mediate platelet aggregation mediate platelet
adhesion activator of protein C -- ANSWER--mediate platelet adhesion
What constituent of the peripheral zone contains glycoproteins responsible for
blood group specificity (ABO), tissue compatibility, and platelet antigenicity?
actin open canalicular system Golgi complex glycocalyx -- ANSWER--
glycocalyx
A tube of anticoagulated blood was centrifuged. After centrifugation which of
the following describes the correct sequence of layers from top to bottom of the
tube?
buffy coat, plasma, red blood cells buffy coat, red blood cells, plasma plasma,
buffy coat, red blood cells red blood cells, buffy coat, plasma -- ANSWER--
plasma, buffy coat, red blood cells
Factor VII is known as:
fibrinogen stable factor christmas factor labile factor -- ANSWER--stable factor
Tissue Factor Pathway Inhibitor inactivates which factor?
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