ONS Chemotherapy Immunotherapy
Certificate Exam Questions And
Answers
/. Define neoadjuvant therapy - Answer-Treatment is given prior to surgery to shrink the
tumor
/.Define adjuvant therapy - Answer-Additional cancer treatment given after the primary
treatment to lower the risk that the cancer reoccur
/.3 subcategories of alkylating agents: - Answer-1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating
agents as they work similarly)
3. Nitrosoureas
/.Common alkylating agents: - Answer-Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
/.Common platinum-based agents: - Answer-Cisplatin (Platinol)
Carboplatin (Paraplatin)
/.What is unique about nitrosoureas agents? - Answer-Able to cross the blood-brain
barrier; can be effective in treating some brain tumors
/.Common nitrosoureas agents: - Answer-Carmustine (BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
/.Hypersensitivity can occur with late doses of: - Answer-Carboplatin
/.These agents are typically categorized as highly emetogenic: - Answer-1. Alkylating
agents
2. Nitrosoureas
/.Pre-administration labs for alkylating agents and nitrosoureas: - Answer-BUN
Creatinine
CBC w/ diff
/.What is the medication Mesna used for? - Answer-Bladder protectant with
administration of cyclophosphamide or ifosfamide
, /.Instruct pts receiving ________ to avoid exposure to cold air and consuming cold
fluids for 3-4 days following treatment - Answer-Oxaliplatin
/.How do antimetabolites function? - Answer-By blocking DNA and RNA growth by
interfering with enzymes needed for normal cell metabolism
/.Antimetabolites work in the ___ phase. - Answer-S
/.Common side effects of antimetabolites: - Answer-Myelosuppression
GI toxicities
Photosensitivity
Hand-foot syndrome
/.Common antimetabolite drugs: - Answer-Azacitidine
Capecitabine
5-FU
Cytarabine
Decitabine
Methotrexate
/.The institute for Safe Medication Practices recommends what route of administration
for vincristine? - Answer-IV piggyback via gravity
/.Anthracycline antitumor abx work by: - Answer-Interfering with enzymes necessary for
DNA to replicate in ALL phases of the cell cycle
/.The two major classifications of antitumor antibiotics are: - Answer-Anthracyclines
Non-anthracyclines
/.Common anthracycline antitumor abx: - Answer-Daunorubicin
Doxorubicin
Epirubicin
Idarubicin
/.The antitumor abx ___________ is not an anthracycline, but has anthracycline-type
properties. - Answer-Mitoxantrone
/.Common non-anthracycline antitumor abx: - Answer-Actinomycin D
Mitomycin C
Bleomycin
/.Monitoring necessary with doxorubicin: - Answer-Vesicant --> extravasation
Cardiac function
Lifetime dose tracking (cardiotoxicity)
Certificate Exam Questions And
Answers
/. Define neoadjuvant therapy - Answer-Treatment is given prior to surgery to shrink the
tumor
/.Define adjuvant therapy - Answer-Additional cancer treatment given after the primary
treatment to lower the risk that the cancer reoccur
/.3 subcategories of alkylating agents: - Answer-1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating
agents as they work similarly)
3. Nitrosoureas
/.Common alkylating agents: - Answer-Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
/.Common platinum-based agents: - Answer-Cisplatin (Platinol)
Carboplatin (Paraplatin)
/.What is unique about nitrosoureas agents? - Answer-Able to cross the blood-brain
barrier; can be effective in treating some brain tumors
/.Common nitrosoureas agents: - Answer-Carmustine (BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
/.Hypersensitivity can occur with late doses of: - Answer-Carboplatin
/.These agents are typically categorized as highly emetogenic: - Answer-1. Alkylating
agents
2. Nitrosoureas
/.Pre-administration labs for alkylating agents and nitrosoureas: - Answer-BUN
Creatinine
CBC w/ diff
/.What is the medication Mesna used for? - Answer-Bladder protectant with
administration of cyclophosphamide or ifosfamide
, /.Instruct pts receiving ________ to avoid exposure to cold air and consuming cold
fluids for 3-4 days following treatment - Answer-Oxaliplatin
/.How do antimetabolites function? - Answer-By blocking DNA and RNA growth by
interfering with enzymes needed for normal cell metabolism
/.Antimetabolites work in the ___ phase. - Answer-S
/.Common side effects of antimetabolites: - Answer-Myelosuppression
GI toxicities
Photosensitivity
Hand-foot syndrome
/.Common antimetabolite drugs: - Answer-Azacitidine
Capecitabine
5-FU
Cytarabine
Decitabine
Methotrexate
/.The institute for Safe Medication Practices recommends what route of administration
for vincristine? - Answer-IV piggyback via gravity
/.Anthracycline antitumor abx work by: - Answer-Interfering with enzymes necessary for
DNA to replicate in ALL phases of the cell cycle
/.The two major classifications of antitumor antibiotics are: - Answer-Anthracyclines
Non-anthracyclines
/.Common anthracycline antitumor abx: - Answer-Daunorubicin
Doxorubicin
Epirubicin
Idarubicin
/.The antitumor abx ___________ is not an anthracycline, but has anthracycline-type
properties. - Answer-Mitoxantrone
/.Common non-anthracycline antitumor abx: - Answer-Actinomycin D
Mitomycin C
Bleomycin
/.Monitoring necessary with doxorubicin: - Answer-Vesicant --> extravasation
Cardiac function
Lifetime dose tracking (cardiotoxicity)
