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Pharmacology HESI test EXAM 2025 PRACTICE GRADED A+ QUESTIONS WITH
CORRECT ANSWERS 2025-2026 VERIFIED
A client is taking danazol (Danocrine) for endometriosis and calls the clinic
nurse to complain of a dark, swollen, and painful leg. What instructions should
the nurse provide the client?
Wear support stockings.
Elevate both legs and apply heat.
Proceed to the closest emergency room.
Walk for 20 to 30 minutes to reduce muscle cramps.
Proceed to the closest emergency room
A dark, swollen, and painful leg is consistent with deep vein thrombosis (DVT), an
adverse effect of danazol, so the client should be instructed to seek immediate
emergency care.
The nurse administers the initial dose of a fentanyl (Duragesic) transdermal
patch to a client with chronic pain. When monitoring the client an hour later,
which assessment is most important for the nurse to obtain?
Level of consciousness.
Moistness of mucosa.
Bowel sound activity.
Numeric pain scale.
Numeric pain scale
Transdermal fentanyl, an opioid analgesic, has an onset and peak of 6 to 12 hours
after the initial dose, so it is most important to determine the client's level of pain,
which can persist as breakthrough pain throughout the 72-hour duration of the patch.
Based on the blood culture and sensitivity results, the healthcare provider
prescribes an IV aminoglycoside antibiotic and discontinues the current
prescription for another broad spectrum antibiotic. The medication
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administration record indicates that the client received the broad spectrum
antibiotic two hours ago. Which action should the nurse implement?
Obtain peak and trough serum levels so the aminoglycoside antibiotic can be
initiated.
Administer the initial dose of the aminoglycoside antibiotic as soon as
possible.
Withhold antibiotic administration until the healthcare provider clarifies the
prescriptions.
Schedule the initial dose of the aminoglycoside antibiotic for the following
day.
Administer the initial dose of the aminoglycoside antibiotic as soon as possible.
Based on the blood culture and sensitivity results, the prescribed aminoglycoside
antibiotic is the most effective in treating the client's infection, so it should be
administered as soon as possible.
When prescribed for a client with hepatic encephalopathy, what is the
therapeutic action of lactulose (Portalac)?
Lowers the pH of the colon.
Softens the stool.
Increases glucose absorption.
Stimulates peristalsis.
Lowers the pH of the colon
Colonic bacteria digest lactulose to create a drug-induced acidic and hyperosmotic
environment that draws water and blood ammonia into the colon. The physiologic
action of lactulose for the client with hepatic encephalopathy is to lower the pH of the
colon which inhibits diffusion of ammonia into the bloodstream
A client calls the clinic and states that she forgot to take her oral
contraceptives for the past two days. Which instruction is best for the nurse to
provide to this client?
Take 2 pills a day for 2 days and use an alternate method of contraception for
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7 days.
Quit the pills for this cycle, use an alternate method of contraception, and
resume pills on the fifth day of menstruation.
Take one extra pill per day for the rest of this cycle, then resume taking pills as
usual next cycle.
Take 4 pills now and use an alternate method of contraception for the rest of
this cycle.
Take 2 pills a day for 2 days and use an alternate method of contraception for 7
days.
A client with pneumonia receives a prescription for tetracycline (Sumycin).
What precaution should the nurse include in this client's teaching?
Take the medication with a glass of orange juice.
Avoid over-the-counter medications containing alcohol.
Avoid diary products for 2 hours after taking the medication.
Do not use teeth whitening agents during the treatment regimen.
Avoid diary products for 2 hours after taking the medication.
Dairy products should not be ingested until at least 2 hours after taking Sumycin
because the calcium from the dairy binds with tetracycline and decreases the
medication's absorption.
A client receives a new prescription for pentazocine (Talwin), a mixed opioid
agonist-antagonist, after an opioid agonist is discontinued. What is the
advantage for the client when the new prescription is implemented?
Tolerance does not occur.
Less agitation is experienced.
The analgesic ceiling is higher.
Respiratory depression is less.
respiratory depression is less
Mixed agonist-antagonists bind as an agonist at the Kappa receptor and as
antagonists or partial agonists on the mu receptor, which produces less respiratory
depression than opioid agonists that are pure mu agonists.
Pharmacology HESI test EXAM 2025 PRACTICE GRADED A+ QUESTIONS WITH
CORRECT ANSWERS 2025-2026 VERIFIED
A client is taking danazol (Danocrine) for endometriosis and calls the clinic
nurse to complain of a dark, swollen, and painful leg. What instructions should
the nurse provide the client?
Wear support stockings.
Elevate both legs and apply heat.
Proceed to the closest emergency room.
Walk for 20 to 30 minutes to reduce muscle cramps.
Proceed to the closest emergency room
A dark, swollen, and painful leg is consistent with deep vein thrombosis (DVT), an
adverse effect of danazol, so the client should be instructed to seek immediate
emergency care.
The nurse administers the initial dose of a fentanyl (Duragesic) transdermal
patch to a client with chronic pain. When monitoring the client an hour later,
which assessment is most important for the nurse to obtain?
Level of consciousness.
Moistness of mucosa.
Bowel sound activity.
Numeric pain scale.
Numeric pain scale
Transdermal fentanyl, an opioid analgesic, has an onset and peak of 6 to 12 hours
after the initial dose, so it is most important to determine the client's level of pain,
which can persist as breakthrough pain throughout the 72-hour duration of the patch.
Based on the blood culture and sensitivity results, the healthcare provider
prescribes an IV aminoglycoside antibiotic and discontinues the current
prescription for another broad spectrum antibiotic. The medication
, Page 2 of 28
administration record indicates that the client received the broad spectrum
antibiotic two hours ago. Which action should the nurse implement?
Obtain peak and trough serum levels so the aminoglycoside antibiotic can be
initiated.
Administer the initial dose of the aminoglycoside antibiotic as soon as
possible.
Withhold antibiotic administration until the healthcare provider clarifies the
prescriptions.
Schedule the initial dose of the aminoglycoside antibiotic for the following
day.
Administer the initial dose of the aminoglycoside antibiotic as soon as possible.
Based on the blood culture and sensitivity results, the prescribed aminoglycoside
antibiotic is the most effective in treating the client's infection, so it should be
administered as soon as possible.
When prescribed for a client with hepatic encephalopathy, what is the
therapeutic action of lactulose (Portalac)?
Lowers the pH of the colon.
Softens the stool.
Increases glucose absorption.
Stimulates peristalsis.
Lowers the pH of the colon
Colonic bacteria digest lactulose to create a drug-induced acidic and hyperosmotic
environment that draws water and blood ammonia into the colon. The physiologic
action of lactulose for the client with hepatic encephalopathy is to lower the pH of the
colon which inhibits diffusion of ammonia into the bloodstream
A client calls the clinic and states that she forgot to take her oral
contraceptives for the past two days. Which instruction is best for the nurse to
provide to this client?
Take 2 pills a day for 2 days and use an alternate method of contraception for
, Page 3 of 28
7 days.
Quit the pills for this cycle, use an alternate method of contraception, and
resume pills on the fifth day of menstruation.
Take one extra pill per day for the rest of this cycle, then resume taking pills as
usual next cycle.
Take 4 pills now and use an alternate method of contraception for the rest of
this cycle.
Take 2 pills a day for 2 days and use an alternate method of contraception for 7
days.
A client with pneumonia receives a prescription for tetracycline (Sumycin).
What precaution should the nurse include in this client's teaching?
Take the medication with a glass of orange juice.
Avoid over-the-counter medications containing alcohol.
Avoid diary products for 2 hours after taking the medication.
Do not use teeth whitening agents during the treatment regimen.
Avoid diary products for 2 hours after taking the medication.
Dairy products should not be ingested until at least 2 hours after taking Sumycin
because the calcium from the dairy binds with tetracycline and decreases the
medication's absorption.
A client receives a new prescription for pentazocine (Talwin), a mixed opioid
agonist-antagonist, after an opioid agonist is discontinued. What is the
advantage for the client when the new prescription is implemented?
Tolerance does not occur.
Less agitation is experienced.
The analgesic ceiling is higher.
Respiratory depression is less.
respiratory depression is less
Mixed agonist-antagonists bind as an agonist at the Kappa receptor and as
antagonists or partial agonists on the mu receptor, which produces less respiratory
depression than opioid agonists that are pure mu agonists.
