1|Page
NBME PATHOLOGY FINAL TEST BANK EXAM LATEST 2025/2026
ACTUAL EXAM WITH COMPLETE QUESTIONS AND CORRECT
DETAILED ANSWERS (100% VERIFIED ANSWERS) |ALREADY
GRADED A+| ||PROFESSOR VERIFIED|| ||BRANDNEW!!!||
What are the symptoms of MHA? - ANSWER-Skin/Mucosal
Bleeding
Hemolytic Anemia
Fever
Renal Insufficiency (HUS)
CNS defects (TTP)
Is PT/PTT changed in TTP or HUS? - ANSWER-No.
Bleeding times increase, but the coagulation cascade is
unaffected.
How is MHA treated? - ANSWER-Corticosteroids and
plasmapheresis.
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What are the qualitative platelet disorders? - ANSWER-Benard
Soulier
Glanzmann Thromboasthenia
Describe Bernard Soulier Syndrome - ANSWER-"BS -- Big
Suckers" => big platelets with mild thrombocytopenia
Platelet adhesion deficiency due to GPIb
Describe Glanzmann's thrombasthenia - ANSWER-Defect of
GP2B3A preventing aggregation of platelets
Normal platelet level with mucosal bleeding (epistaxis)
What is the effect of aspirin on coagulation? - ANSWER-
Irreversibly inhibits COX enzymes which produce TXA2 in
platelets. Results in inhibited clotting ability.
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What is secondary hemostasis? - ANSWER-Stabilizes platelet
plug via coagulation cascade that generates thrombin which
converts fibrinogen to fibrin which gets cross-linked
Describe the extrinsic activation pathway of coagulation. -
ANSWER-Traumatic injury exposes "tissue factor" aka Factor 7
which initiates the cascade.
Describe the intrinsic activation pathway of coagulation -
ANSWER-Subendothelial collagen activates factor XII
What are the symptoms of a defect in Secondary hemostasis? -
ANSWER-Deep tissue bleeds into joints/muscles (Hemarthosis)
Persistent bleeding after surgery
Prolonged PT/PTT times
What is prothrombin time (PT)? - ANSWER-A measure of Tissue
Factor (7) and the common pathway
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What is Partial Thromboplastin Time (PTT)? - ANSWER-
Measures the intrinsic pathway and common pathway.
Describe Hemophilia A - ANSWER-X-Linked recessive deficit of
clotting factor 8.
What are the signs of hemophilia A? - ANSWER-Prolonged PTT,
normal PT, corrects with mixing.
Post-surgical bleeds and hemarthrosis.
tx is recombinant factor 8
Describe Hemophilia B/Christmas Disease. - ANSWER-a
deficiency in factor 9 levels.
Presents identical to Hemophilia A
NBME PATHOLOGY FINAL TEST BANK EXAM LATEST 2025/2026
ACTUAL EXAM WITH COMPLETE QUESTIONS AND CORRECT
DETAILED ANSWERS (100% VERIFIED ANSWERS) |ALREADY
GRADED A+| ||PROFESSOR VERIFIED|| ||BRANDNEW!!!||
What are the symptoms of MHA? - ANSWER-Skin/Mucosal
Bleeding
Hemolytic Anemia
Fever
Renal Insufficiency (HUS)
CNS defects (TTP)
Is PT/PTT changed in TTP or HUS? - ANSWER-No.
Bleeding times increase, but the coagulation cascade is
unaffected.
How is MHA treated? - ANSWER-Corticosteroids and
plasmapheresis.
,2|Page
What are the qualitative platelet disorders? - ANSWER-Benard
Soulier
Glanzmann Thromboasthenia
Describe Bernard Soulier Syndrome - ANSWER-"BS -- Big
Suckers" => big platelets with mild thrombocytopenia
Platelet adhesion deficiency due to GPIb
Describe Glanzmann's thrombasthenia - ANSWER-Defect of
GP2B3A preventing aggregation of platelets
Normal platelet level with mucosal bleeding (epistaxis)
What is the effect of aspirin on coagulation? - ANSWER-
Irreversibly inhibits COX enzymes which produce TXA2 in
platelets. Results in inhibited clotting ability.
,3|Page
What is secondary hemostasis? - ANSWER-Stabilizes platelet
plug via coagulation cascade that generates thrombin which
converts fibrinogen to fibrin which gets cross-linked
Describe the extrinsic activation pathway of coagulation. -
ANSWER-Traumatic injury exposes "tissue factor" aka Factor 7
which initiates the cascade.
Describe the intrinsic activation pathway of coagulation -
ANSWER-Subendothelial collagen activates factor XII
What are the symptoms of a defect in Secondary hemostasis? -
ANSWER-Deep tissue bleeds into joints/muscles (Hemarthosis)
Persistent bleeding after surgery
Prolonged PT/PTT times
What is prothrombin time (PT)? - ANSWER-A measure of Tissue
Factor (7) and the common pathway
, 4|Page
What is Partial Thromboplastin Time (PTT)? - ANSWER-
Measures the intrinsic pathway and common pathway.
Describe Hemophilia A - ANSWER-X-Linked recessive deficit of
clotting factor 8.
What are the signs of hemophilia A? - ANSWER-Prolonged PTT,
normal PT, corrects with mixing.
Post-surgical bleeds and hemarthrosis.
tx is recombinant factor 8
Describe Hemophilia B/Christmas Disease. - ANSWER-a
deficiency in factor 9 levels.
Presents identical to Hemophilia A
