Maryville University NURS615 Pharmacology Exam 4
UPDATED ACTUAL Questions and CORRECT Answers
1. What are examples of inhaled Short-acting Albuterol and levabuterol
Beta Agonists? (SABAs)
2. What is the MOA of inhaled beta agonists? To relax airway smooth muscle by increasing
cyclic cAMP; dilation and opening of airway
3. What is the use of inhaled beta agonists? Used in bronchospasm associated with:
asthma, bronchitis, and COPD
4. When are SABAs used (albuterol and lev- For relief of ACUTE asthma attacks
abuterol)?
5. Is albuterol approved in children under 4? Yes.
6. How do beta-2 agonists affect calcium? They open large conductions in calcium acti-
vated potassium channels = hyperpolarized
airway smooth muscle cells
1. decreased intracellular calcium
2. increased potassium concentration
3. decreased myocleynase activity = smooth
muscle relaxation and bronchodilation
7. What are examples of long-acting beta ag- salmetrol and formoterol
onists (LABAs)?
8. What are LABAs (salmeterol and for- Used for PREVENTION or long term treat-
moterol) used for? ment of asthma
NOT for acute attacks; not first line treat-
ment
CANNOT be used alone
, Maryville University NURS615 Pharmacology Exam 4
UPDATED ACTUAL Questions and CORRECT Answers
9. What population should LABAs NOT be African Americans
prescribed in?
10. What is special about the beta 2 adrener- This gene causes LABAs to worsen asthma
gic receptor gene? control
11. Who is more likely to have the beta 2 African Americans; this genotype is present
adrenergic receptor gene? in 1/6th of the U.S. population
12. How does the beta 2 adrenergic recep- Asthmatics with this gene are at risk for de-
tor gene cause worsening asthma control creased airflow and worsening asthma con-
when LABAs are taken? trol
13. What are adverse effects of inhaled beta Tachycardia and tremors
agonists?
14. What is the absorption of inhaled beta ag- Very little systemic absorption
onists?
15. What are examples of anticholinergics/an- ipatroprium (Atrovent) and tiotroprium
timuscarinics in maintenance therapy of (Spiriva)
COPD?
16. What is the MOA of anticholinergics (ipat- They block muscarinic receptors decreasing
roprium and tiotroprium)? the formation of cAMP
CAUSES BRONCHODILATION BY:
1. decreasing smooth muscle contraction of
lungs (mainly on M3 receptors)
2. decreases mucous secretion
17. What are ipatroprium and tiotroprium Maintenance of COPD
used for?
, Maryville University NURS615 Pharmacology Exam 4
Study online at https://quizlet.com/_hm6y9h
18. What is tiotroprium (Spiriva)? LONG-ACTING bronchodilator for COPD;
better absorbed from lung than ipatroprium
(Atrovent)
19. What is ipotroprium (Atrovent)? SHORT-ACTING bronchodilator for COPD
20. What bronchodilator is the best choice in Ipatroprium (Atrovent)
patients taking propranolol?
21. What are the adverse effects of ipatropri- Anticholinergic -- can't see, can't pee, can't
um and tiotroprium? spit, can't shit
22. What are examples of inhaled corticos- fluticasone (Flonase), budesonide (Pul-
teroids? micort), beclomethasone diproprionate
(QVAR)
23. What are inhaled corticosteroids used for? Long-term treatment of asthma (severe,
persistent asthma); taken everyday
24. What is the absorption of inhaled corticos- Rapid absorption from lung tissues; greater
teroids? with use of spacer
25. What effects do inhaled corticosteroids Anti-inflammatory and vasoconstrictor ef-
have? fects
Highly selective agonists at the glucocorti-
coid receptor and some activity at androgen,
estrogen, and corticoid receptors
26. What is the MOA of inhaled corticos- INHIBITS mast cell migration to bronchial
teroids? tissues
27. What is the bioavailability of inhaled corti-
costeroids?
UPDATED ACTUAL Questions and CORRECT Answers
1. What are examples of inhaled Short-acting Albuterol and levabuterol
Beta Agonists? (SABAs)
2. What is the MOA of inhaled beta agonists? To relax airway smooth muscle by increasing
cyclic cAMP; dilation and opening of airway
3. What is the use of inhaled beta agonists? Used in bronchospasm associated with:
asthma, bronchitis, and COPD
4. When are SABAs used (albuterol and lev- For relief of ACUTE asthma attacks
abuterol)?
5. Is albuterol approved in children under 4? Yes.
6. How do beta-2 agonists affect calcium? They open large conductions in calcium acti-
vated potassium channels = hyperpolarized
airway smooth muscle cells
1. decreased intracellular calcium
2. increased potassium concentration
3. decreased myocleynase activity = smooth
muscle relaxation and bronchodilation
7. What are examples of long-acting beta ag- salmetrol and formoterol
onists (LABAs)?
8. What are LABAs (salmeterol and for- Used for PREVENTION or long term treat-
moterol) used for? ment of asthma
NOT for acute attacks; not first line treat-
ment
CANNOT be used alone
, Maryville University NURS615 Pharmacology Exam 4
UPDATED ACTUAL Questions and CORRECT Answers
9. What population should LABAs NOT be African Americans
prescribed in?
10. What is special about the beta 2 adrener- This gene causes LABAs to worsen asthma
gic receptor gene? control
11. Who is more likely to have the beta 2 African Americans; this genotype is present
adrenergic receptor gene? in 1/6th of the U.S. population
12. How does the beta 2 adrenergic recep- Asthmatics with this gene are at risk for de-
tor gene cause worsening asthma control creased airflow and worsening asthma con-
when LABAs are taken? trol
13. What are adverse effects of inhaled beta Tachycardia and tremors
agonists?
14. What is the absorption of inhaled beta ag- Very little systemic absorption
onists?
15. What are examples of anticholinergics/an- ipatroprium (Atrovent) and tiotroprium
timuscarinics in maintenance therapy of (Spiriva)
COPD?
16. What is the MOA of anticholinergics (ipat- They block muscarinic receptors decreasing
roprium and tiotroprium)? the formation of cAMP
CAUSES BRONCHODILATION BY:
1. decreasing smooth muscle contraction of
lungs (mainly on M3 receptors)
2. decreases mucous secretion
17. What are ipatroprium and tiotroprium Maintenance of COPD
used for?
, Maryville University NURS615 Pharmacology Exam 4
Study online at https://quizlet.com/_hm6y9h
18. What is tiotroprium (Spiriva)? LONG-ACTING bronchodilator for COPD;
better absorbed from lung than ipatroprium
(Atrovent)
19. What is ipotroprium (Atrovent)? SHORT-ACTING bronchodilator for COPD
20. What bronchodilator is the best choice in Ipatroprium (Atrovent)
patients taking propranolol?
21. What are the adverse effects of ipatropri- Anticholinergic -- can't see, can't pee, can't
um and tiotroprium? spit, can't shit
22. What are examples of inhaled corticos- fluticasone (Flonase), budesonide (Pul-
teroids? micort), beclomethasone diproprionate
(QVAR)
23. What are inhaled corticosteroids used for? Long-term treatment of asthma (severe,
persistent asthma); taken everyday
24. What is the absorption of inhaled corticos- Rapid absorption from lung tissues; greater
teroids? with use of spacer
25. What effects do inhaled corticosteroids Anti-inflammatory and vasoconstrictor ef-
have? fects
Highly selective agonists at the glucocorti-
coid receptor and some activity at androgen,
estrogen, and corticoid receptors
26. What is the MOA of inhaled corticos- INHIBITS mast cell migration to bronchial
teroids? tissues
27. What is the bioavailability of inhaled corti-
costeroids?
