BIMM 134 FINAL questions and
answers graded A+
Cancer Immunology (4) - correct answer ✔✔ 1) Immune system recognizes/kills cancer cells
2) c.c hide/prevent immune cell detection/destruction
3)c.c kill, destroy, & disable our immune cells
4)our counterattack
Monocytes - correct answer ✔✔ in the bone marrow, goes into tissue cells and differentiate
into macrophages.
macrophages (2) - correct answer ✔✔ class M1
class M2
class M1 - correct answer ✔✔ good
-tumor suppressive
-inc immune fxn
class M2 - correct answer ✔✔ bad
-(TAM)=tumor associated macrophage
-immunosuppressive
-tumor angiogenic, metastatic stimulating
,innate immunity - correct answer ✔✔ Immunity that is present before exposure and effective
from birth. Responds to a broad range of pathogens.
-natural killer cells (NKC)
no NKC activation - correct answer ✔✔ -not many stress ligands (some stimulatory)
-presence of Ag and MHC class 1 display (inhibitory proteins) [inhibitory=chkpt]
(in normal cell, inhibitory wins->cell lives)
NKC and killing the cell - correct answer ✔✔ -inc/high activation (stress ligands)
[stimulatory=kill]
-or dec/low inhibitory (removing Ag & MHC class 1 display)
results in cell death (cancer cell)
killing cancer cell via FASL - correct answer ✔✔ a) activate CT cells via APC
b) CTC binds to cancer cell
c)kill c.c. via extrinsic (ligand) or intrinsic path (activate GRANZYME B to activate Bid)
Helper T cells (CD4+) (binds to___ on APC) - correct answer ✔✔ -Binds to MHC II on APC's
-Activates whole immune response including: B cell, CT cell, macrophage, & NK cell activity
(HIV kills helper T cells)
2 stimulatory methods of killing the cancer cell (APC, CTC, C.C) - correct answer ✔✔ Ag/MHC I
and B7/CD28
, 1)
-APC has Ag and MHC I
-binds to T cell receptor on Cytotoxic T cells and activates it
-another TCR on the CTC attaches to the Ag and MHC on a cancer cell
->cancer cell death
2)-APC has B7
-binds to CD 28 on CT cells and activates it
-another CD 28 on the CTC attaches to the B7 on a cancer cell
->c.c. death
2 inhibitory paths of not killing the cancer cell (APC,CTC, CC) - correct answer ✔✔ B7/CTLA4 &
PD-LI/PD-I*
-APC has B7
-binds to CTLA4 on CT cells and activates it
-another CTLA4 on the CTC attaches to the B7 on a cancer cell
-dec T cell activation
->c.cell survives
-APC has PD-LI
-binds to PD-I on CT cells and activates it
-PD-I on the CTC attaches to the B7 on a cancer cell
-dec T cell activation
answers graded A+
Cancer Immunology (4) - correct answer ✔✔ 1) Immune system recognizes/kills cancer cells
2) c.c hide/prevent immune cell detection/destruction
3)c.c kill, destroy, & disable our immune cells
4)our counterattack
Monocytes - correct answer ✔✔ in the bone marrow, goes into tissue cells and differentiate
into macrophages.
macrophages (2) - correct answer ✔✔ class M1
class M2
class M1 - correct answer ✔✔ good
-tumor suppressive
-inc immune fxn
class M2 - correct answer ✔✔ bad
-(TAM)=tumor associated macrophage
-immunosuppressive
-tumor angiogenic, metastatic stimulating
,innate immunity - correct answer ✔✔ Immunity that is present before exposure and effective
from birth. Responds to a broad range of pathogens.
-natural killer cells (NKC)
no NKC activation - correct answer ✔✔ -not many stress ligands (some stimulatory)
-presence of Ag and MHC class 1 display (inhibitory proteins) [inhibitory=chkpt]
(in normal cell, inhibitory wins->cell lives)
NKC and killing the cell - correct answer ✔✔ -inc/high activation (stress ligands)
[stimulatory=kill]
-or dec/low inhibitory (removing Ag & MHC class 1 display)
results in cell death (cancer cell)
killing cancer cell via FASL - correct answer ✔✔ a) activate CT cells via APC
b) CTC binds to cancer cell
c)kill c.c. via extrinsic (ligand) or intrinsic path (activate GRANZYME B to activate Bid)
Helper T cells (CD4+) (binds to___ on APC) - correct answer ✔✔ -Binds to MHC II on APC's
-Activates whole immune response including: B cell, CT cell, macrophage, & NK cell activity
(HIV kills helper T cells)
2 stimulatory methods of killing the cancer cell (APC, CTC, C.C) - correct answer ✔✔ Ag/MHC I
and B7/CD28
, 1)
-APC has Ag and MHC I
-binds to T cell receptor on Cytotoxic T cells and activates it
-another TCR on the CTC attaches to the Ag and MHC on a cancer cell
->cancer cell death
2)-APC has B7
-binds to CD 28 on CT cells and activates it
-another CD 28 on the CTC attaches to the B7 on a cancer cell
->c.c. death
2 inhibitory paths of not killing the cancer cell (APC,CTC, CC) - correct answer ✔✔ B7/CTLA4 &
PD-LI/PD-I*
-APC has B7
-binds to CTLA4 on CT cells and activates it
-another CTLA4 on the CTC attaches to the B7 on a cancer cell
-dec T cell activation
->c.cell survives
-APC has PD-LI
-binds to PD-I on CT cells and activates it
-PD-I on the CTC attaches to the B7 on a cancer cell
-dec T cell activation
