MCAT EXAM 1 B/B Section Questions
and Answers
#1 Based on the data presented in the passage, which statement best describes the
HSP110ΔE9 allele? - ANS-Cancer-suppressing and dominant to HSP110WTbec
from the second chart you can see that E9 has a greater percentage....also from figure
1 (not shown here) you can see that it is a suppressor
#2 Based on the passage, in MSI CRC primary tumor cells, the size of the deletion in
the HSP110 T17 microsatellite is inversely correlated with: - ANS-the number of mature
HSP110WT transcripts synthesized.
bc based on figure 1 it shows that as the size of the deletion increases, the amount of
wild type decreases and e delta 9 increases
#3 A man with a CRC mutation that results in the synthesis of HSP110ΔE9 and a
woman that does not carry this mutation in any of her tissues have a child. What is the
percent chance that the child will inherit the CRC mutation? - ANS-0%
This is because it says it is in cancerous tissue, thus it is a somatic not germline
mutation (meaning it is only passed on by tissues and not through gametes)
#4 Which nucleotide pairing(s) would be recognized by the MMR system during DNA
replication?
I. dTMP and dCMP
II. dGMP and dAMP
III. dAMP and dTMP - ANS-I and II because T/C and G/A do not pair up but A/T do pair
up
#5 The information in the passage best supports the conclusion that Intron 8 of HSP110
most likely contains which of the following? - ANS-Splice acceptor site
Introns get spliced out of product
#6 According to the information in the passage, HSP110 is most likely which type of
protein? - ANS-Chaperone
because it says in the passage...facilitates proper protein folding and inhibits the
formation of nonfunctional protein aggregates
, btw adhesion proteins allow cells to bind together
clathrin protein form coated vesicles
#7 Which amino acid, in addition to tryptophan, is most likely to be transported by AT1?
- ANS-Phenylalanine
it's cyclic and neutral like tryptophan so it would probably be recognized by the same
transport stuffq
#8 Based on the information in the passage, a mature AT1 mRNA is most likely to
contain a sequence coding for which genetic factor(s)? - ANS-A. Signal sequence
B. Introns
C. Promoter
D. Nuclear localization signal
Not B because mature RNA don't have introns (they're already been spliced out)
not C because that is only in DNA
Not D, because AT1 is not going to the nucleus, it's. a transmembrane proteins and
would need to go through ER/golgi to be transported out of the cell
Which effect did a protein-free diet have on DSS-treated +/y and -/y mice, respectively?
- ANS-the table shows they both lost weight
Pellagra also results from a deficiency of nicotinamide, which is synthesized from
tryptophan. Nicotinamide nucleotides are neither oxidized nor reduced during which
step of cellular respiration? - ANS-A. Glycolysis
B. Chemiosmosis
C. Citric acid cycle
D. Electron transport chain
B!!!
Nicotinamide is NAD+, and this is oxidized and reduced in everything except
chemiosmosis which is just a type of diffusion across membrane
If a man with a mutant copy of Ace2 has a child with a woman that is heterozygous for
the mutant Ace2 allele, what is the probability that the child will be a female and
homozygous for the mutant Ace2 allele? - ANS-0.25
The trait is X linked so do a punnetts square
During the initiation of muscle contraction, mysosin binds actin after troponin binds to
which ion? - ANS-Ca2+
and Answers
#1 Based on the data presented in the passage, which statement best describes the
HSP110ΔE9 allele? - ANS-Cancer-suppressing and dominant to HSP110WTbec
from the second chart you can see that E9 has a greater percentage....also from figure
1 (not shown here) you can see that it is a suppressor
#2 Based on the passage, in MSI CRC primary tumor cells, the size of the deletion in
the HSP110 T17 microsatellite is inversely correlated with: - ANS-the number of mature
HSP110WT transcripts synthesized.
bc based on figure 1 it shows that as the size of the deletion increases, the amount of
wild type decreases and e delta 9 increases
#3 A man with a CRC mutation that results in the synthesis of HSP110ΔE9 and a
woman that does not carry this mutation in any of her tissues have a child. What is the
percent chance that the child will inherit the CRC mutation? - ANS-0%
This is because it says it is in cancerous tissue, thus it is a somatic not germline
mutation (meaning it is only passed on by tissues and not through gametes)
#4 Which nucleotide pairing(s) would be recognized by the MMR system during DNA
replication?
I. dTMP and dCMP
II. dGMP and dAMP
III. dAMP and dTMP - ANS-I and II because T/C and G/A do not pair up but A/T do pair
up
#5 The information in the passage best supports the conclusion that Intron 8 of HSP110
most likely contains which of the following? - ANS-Splice acceptor site
Introns get spliced out of product
#6 According to the information in the passage, HSP110 is most likely which type of
protein? - ANS-Chaperone
because it says in the passage...facilitates proper protein folding and inhibits the
formation of nonfunctional protein aggregates
, btw adhesion proteins allow cells to bind together
clathrin protein form coated vesicles
#7 Which amino acid, in addition to tryptophan, is most likely to be transported by AT1?
- ANS-Phenylalanine
it's cyclic and neutral like tryptophan so it would probably be recognized by the same
transport stuffq
#8 Based on the information in the passage, a mature AT1 mRNA is most likely to
contain a sequence coding for which genetic factor(s)? - ANS-A. Signal sequence
B. Introns
C. Promoter
D. Nuclear localization signal
Not B because mature RNA don't have introns (they're already been spliced out)
not C because that is only in DNA
Not D, because AT1 is not going to the nucleus, it's. a transmembrane proteins and
would need to go through ER/golgi to be transported out of the cell
Which effect did a protein-free diet have on DSS-treated +/y and -/y mice, respectively?
- ANS-the table shows they both lost weight
Pellagra also results from a deficiency of nicotinamide, which is synthesized from
tryptophan. Nicotinamide nucleotides are neither oxidized nor reduced during which
step of cellular respiration? - ANS-A. Glycolysis
B. Chemiosmosis
C. Citric acid cycle
D. Electron transport chain
B!!!
Nicotinamide is NAD+, and this is oxidized and reduced in everything except
chemiosmosis which is just a type of diffusion across membrane
If a man with a mutant copy of Ace2 has a child with a woman that is heterozygous for
the mutant Ace2 allele, what is the probability that the child will be a female and
homozygous for the mutant Ace2 allele? - ANS-0.25
The trait is X linked so do a punnetts square
During the initiation of muscle contraction, mysosin binds actin after troponin binds to
which ion? - ANS-Ca2+
