BIMM 114 Final questions with 100%
correct answers
What are 4 kinds of oncoviruses with dsDNA genomes? - correct answer ✔✔ Papillomaviridae,
polyomaviridae, Adenoviridae, Herpesviridae
What are 2 tumor suppressors which prevent cancer? - correct answer ✔✔ Rb
(Retinoblastoma): binds to the E2F transcription factor and stops the activation of the cell cycle
genes
p53: responds to DNA damage by inducing apoptosis and cell cycle arrest
Which families of viruses disrupt Rb and p53? - correct answer ✔✔ Polyomaviridae and
papillomaviridae
What are pathogens in the polyomaviridae family? - correct answer ✔✔ human
polyomaviruses: nearly everyone has been infected with one; problems in immune
compromised people (ex. HIV or transplant recipients)
Merkel Cell polyomavirus: aggressive skin carcinoma
What are pathogens in the papillomaviridae family? - correct answer ✔✔ human
papillomaviruses: nearly everyone has been infected with one; mostly cause warts, but
problematic in immune compromised people
some sexually transmitted strains (ex. HPV16 or 18) can cause cancer - cervical (mostly), head,
neck
, Where are HeLa cells derived from, and what virus caused the cancer? - correct answer ✔✔ first
immortalized cell line
from HPV18 cervical cancer cells from Henrietta Lacks
What do the genomes of polyomaviridae and papillomaviridae families look like? What
Baltimore Group are they a part of? Are they enveloped? Whose polymerases do they use for
replication and mRNA synthesis? - correct answer ✔✔ Baltimore Group I --> dsDNA and circular
--> replicate in the nucleus
dsDNA wrapped around host histone --> called minichromosome
non-enveloped
polymerases are all from the host
What is the life cycle of polyomaviridae and papillomaviridae families like? - correct answer ✔✔
entry: endocytosis
capsid disassembly + enter nucleus + produce early proteins: genome and proteins are brought
into the nucleus; "early genes" are transcribed by host DdRp; proteins reimported into nucleus
genome replication and late proteins: genome replicated by host DdDp + help from viral
proteins; "late genes" are transcribed and translated
exit by cell lysis
correct answers
What are 4 kinds of oncoviruses with dsDNA genomes? - correct answer ✔✔ Papillomaviridae,
polyomaviridae, Adenoviridae, Herpesviridae
What are 2 tumor suppressors which prevent cancer? - correct answer ✔✔ Rb
(Retinoblastoma): binds to the E2F transcription factor and stops the activation of the cell cycle
genes
p53: responds to DNA damage by inducing apoptosis and cell cycle arrest
Which families of viruses disrupt Rb and p53? - correct answer ✔✔ Polyomaviridae and
papillomaviridae
What are pathogens in the polyomaviridae family? - correct answer ✔✔ human
polyomaviruses: nearly everyone has been infected with one; problems in immune
compromised people (ex. HIV or transplant recipients)
Merkel Cell polyomavirus: aggressive skin carcinoma
What are pathogens in the papillomaviridae family? - correct answer ✔✔ human
papillomaviruses: nearly everyone has been infected with one; mostly cause warts, but
problematic in immune compromised people
some sexually transmitted strains (ex. HPV16 or 18) can cause cancer - cervical (mostly), head,
neck
, Where are HeLa cells derived from, and what virus caused the cancer? - correct answer ✔✔ first
immortalized cell line
from HPV18 cervical cancer cells from Henrietta Lacks
What do the genomes of polyomaviridae and papillomaviridae families look like? What
Baltimore Group are they a part of? Are they enveloped? Whose polymerases do they use for
replication and mRNA synthesis? - correct answer ✔✔ Baltimore Group I --> dsDNA and circular
--> replicate in the nucleus
dsDNA wrapped around host histone --> called minichromosome
non-enveloped
polymerases are all from the host
What is the life cycle of polyomaviridae and papillomaviridae families like? - correct answer ✔✔
entry: endocytosis
capsid disassembly + enter nucleus + produce early proteins: genome and proteins are brought
into the nucleus; "early genes" are transcribed by host DdRp; proteins reimported into nucleus
genome replication and late proteins: genome replicated by host DdDp + help from viral
proteins; "late genes" are transcribed and translated
exit by cell lysis
