NEW HEMATOLOGY HAD 315 WEEK 15
PART 1 MYELODYSPLASTIC SYNDROME| HAD 315
HEMATOLOGY WEEK 15 PART 2
LYMPHOMAS WITH Q&A
What are examples of mature T cell, NK cell, and Hodgkin lymphomas according to the
WHO 2016 classification?
Mature T and NK cell neoplasms:
T cell prolymphocytic leukemia
T cell large granular lymphocytic leukemia
Sézary syndrome
Adult T cell leukemia/lymphoma
Extranodal NK/T cell lymphoma, nasal type
Enteropathy-associated T cell lymphoma
Page 1 of 97
,Hepatosplenic T cell lymphoma
Subcutaneous panniculitis-like T cell lymphoma
Angioimmunoblastic T cell lymphoma
Anaplastic large cell lymphoma (ALCL), ALK positive
Anaplastic large cell lymphoma (ALCL), ALK negative
Peripheral T cell lymphoma, not otherwise specified
Hodgkin lymphoma:
Nodular lymphocyte-predominant Hodgkin lymphoma Classical Hodgkin lymphoma:
Nodular sclerosis
Mixed cellularity
Page 2 of 97
,Lymphocyte-rich
Lymphocyte-depleted
How is the diagnosis and classification of lymphoid neoplasms performed?
Morphology, flow cytometry, molecular and chromosome analysis
Morphologic appearance from PB (Peripheral Blood), BM (Bone Marrow), or tissue biopsy
Can show:
Normal or reactive lymphocytes
Lymphoid neoplasms which are:
Often homogeneous (expansion of a single cell type)
Page 3 of 97
, Occasionally show abnormal or bizarre morphology
How are mature lymphoid neoplasms characterized and classified?
-They are a heterogeneous group of disorders -Grouped
based on distribution of disease:
-Leukemia: primarily affects the blood and bone marrow
-Lymphoma: primarily affects lymphoid tissues
-WHO classification groups leukemia and lymphoma together
What are key features and the diagnostic basis of lymphoma?
-Involves uninhibited growth of cellular elements in lymphatic tissue
-Characterized by abnormal lymph node enlargement and replacement of normal structure -
Diagnosis is made through histologic examination of the lymph node
What are examples of mature B cell neoplasms according to the WHO 2016 classification?
Chronic lymphocytic leukemia / Small lymphocytic lymphoma
Page 4 of 97
PART 1 MYELODYSPLASTIC SYNDROME| HAD 315
HEMATOLOGY WEEK 15 PART 2
LYMPHOMAS WITH Q&A
What are examples of mature T cell, NK cell, and Hodgkin lymphomas according to the
WHO 2016 classification?
Mature T and NK cell neoplasms:
T cell prolymphocytic leukemia
T cell large granular lymphocytic leukemia
Sézary syndrome
Adult T cell leukemia/lymphoma
Extranodal NK/T cell lymphoma, nasal type
Enteropathy-associated T cell lymphoma
Page 1 of 97
,Hepatosplenic T cell lymphoma
Subcutaneous panniculitis-like T cell lymphoma
Angioimmunoblastic T cell lymphoma
Anaplastic large cell lymphoma (ALCL), ALK positive
Anaplastic large cell lymphoma (ALCL), ALK negative
Peripheral T cell lymphoma, not otherwise specified
Hodgkin lymphoma:
Nodular lymphocyte-predominant Hodgkin lymphoma Classical Hodgkin lymphoma:
Nodular sclerosis
Mixed cellularity
Page 2 of 97
,Lymphocyte-rich
Lymphocyte-depleted
How is the diagnosis and classification of lymphoid neoplasms performed?
Morphology, flow cytometry, molecular and chromosome analysis
Morphologic appearance from PB (Peripheral Blood), BM (Bone Marrow), or tissue biopsy
Can show:
Normal or reactive lymphocytes
Lymphoid neoplasms which are:
Often homogeneous (expansion of a single cell type)
Page 3 of 97
, Occasionally show abnormal or bizarre morphology
How are mature lymphoid neoplasms characterized and classified?
-They are a heterogeneous group of disorders -Grouped
based on distribution of disease:
-Leukemia: primarily affects the blood and bone marrow
-Lymphoma: primarily affects lymphoid tissues
-WHO classification groups leukemia and lymphoma together
What are key features and the diagnostic basis of lymphoma?
-Involves uninhibited growth of cellular elements in lymphatic tissue
-Characterized by abnormal lymph node enlargement and replacement of normal structure -
Diagnosis is made through histologic examination of the lymph node
What are examples of mature B cell neoplasms according to the WHO 2016 classification?
Chronic lymphocytic leukemia / Small lymphocytic lymphoma
Page 4 of 97
