NSG 533 ADVANCED
PHARMACOLOGY ACTUAL
TEST 1 QUESTIONS AND
CORRECT ANSWERS 2025/2026
LATEST UPDATE GRADED A+ .
,1. Which of the following SSRIs requires up to a 5-week washout period because of the
long half-life of its potent active metabolite?
A. Escitalopram
B. Fluvoxamine
C. Fluoxetine
D. Sertraline 🗸🗸 CORRECT ANSWER C
2. Which of the following symptoms is most likely to improve within approxi- mately 1 week
of starting treatment?
A. Depressed mood
B. Suicidal thoughts
C. Anhedonia
D. Sleep 🗸🗸 CORRECT ANSWER D
3. Of the following combinations of medications, which one would you want to avoid?
A. Fluoxetine-lithium
B. Fluoxetine-phenelzine
C. Citalopram-valproic acid
D. Citalopram-aripiprazole 🗸🗸 CORRECT ANSWER B
4. A 26-year-old man with a history of depression has been taking sertraline 200 mg/day for 12 weeks with no response.
The patient has no other complications. The physician asks for your recommendation. The most reasonable recommen-
dation would be to 🗸🗸 CORRECT ANSWER
A. Increase sertraline
B. Add fluoxetine
C. Switch to amitriptyline
D. Change to venlafaxine
E. Decrease sertraline 🗸🗸 CORRECT ANSWER D
5. Which of the following is a dangerous combination?
A. MAOI-lorazepam
B. MAOI-acetaminophen
, C. MAOI-meperidine
D. MAOI-ziprasidone 🗸🗸 CORRECT ANSWER C
6. A 23-year-old married white woman comes to the outpatient psychiatric clinic
complaining of decreased sleep, decreased appetite, decreased concentration, depressed
mood, thoughts of death, and lack of interest in activities for 6 weeks' duration.
She has
no history of psychiatric illness and takes no medications except for Ortho-Tri Cyclen Lo
daily. Based upon the patients symptoms, choose the best medication to treat this patient.
A. Nefazodone 100 mg po twice daily
B. Paroxetine 20 mg po daily
C. St. John's wort 300 mg po three times daily
D. Amitriptyline 25 mg at bedtime 🗸🗸 CORRECT ANSWER B
7. A 36-year-old man is admitted to the hospital for a severe methicillin-resistant Staphylococcus aureus diabetic foot
infection and is started on linezolid 600 mg IV every 12 hours. His medication profile includes paroxetine 40 mg
every morning, trazodone 100 mg at bedtime as needed for sleep, and metformin 1000 mg po twice daily. After 3
days on these medications, the patient becomes agitated, confused, and di- aphoretic and develops myoclonic jerks
Which of the following is the most likely diagnosis?
A. Overdose of metformin
B. Bacterial meningitis
C. Neuroleptic malignant syndrome
D. Serotonin syndrome 🗸🗸 CORRECT ANSWER D
8. A 46-year-old woman presents to the psychiatric outpatient clinic for fol- low-up treatment of major
depression. She is currently on paroxetine 10 mg at bedtime, which she started taking 2 months ago when
admitted to the psychiatric hospital for suicidal ideation. During the interview, she says that she
PHARMACOLOGY ACTUAL
TEST 1 QUESTIONS AND
CORRECT ANSWERS 2025/2026
LATEST UPDATE GRADED A+ .
,1. Which of the following SSRIs requires up to a 5-week washout period because of the
long half-life of its potent active metabolite?
A. Escitalopram
B. Fluvoxamine
C. Fluoxetine
D. Sertraline 🗸🗸 CORRECT ANSWER C
2. Which of the following symptoms is most likely to improve within approxi- mately 1 week
of starting treatment?
A. Depressed mood
B. Suicidal thoughts
C. Anhedonia
D. Sleep 🗸🗸 CORRECT ANSWER D
3. Of the following combinations of medications, which one would you want to avoid?
A. Fluoxetine-lithium
B. Fluoxetine-phenelzine
C. Citalopram-valproic acid
D. Citalopram-aripiprazole 🗸🗸 CORRECT ANSWER B
4. A 26-year-old man with a history of depression has been taking sertraline 200 mg/day for 12 weeks with no response.
The patient has no other complications. The physician asks for your recommendation. The most reasonable recommen-
dation would be to 🗸🗸 CORRECT ANSWER
A. Increase sertraline
B. Add fluoxetine
C. Switch to amitriptyline
D. Change to venlafaxine
E. Decrease sertraline 🗸🗸 CORRECT ANSWER D
5. Which of the following is a dangerous combination?
A. MAOI-lorazepam
B. MAOI-acetaminophen
, C. MAOI-meperidine
D. MAOI-ziprasidone 🗸🗸 CORRECT ANSWER C
6. A 23-year-old married white woman comes to the outpatient psychiatric clinic
complaining of decreased sleep, decreased appetite, decreased concentration, depressed
mood, thoughts of death, and lack of interest in activities for 6 weeks' duration.
She has
no history of psychiatric illness and takes no medications except for Ortho-Tri Cyclen Lo
daily. Based upon the patients symptoms, choose the best medication to treat this patient.
A. Nefazodone 100 mg po twice daily
B. Paroxetine 20 mg po daily
C. St. John's wort 300 mg po three times daily
D. Amitriptyline 25 mg at bedtime 🗸🗸 CORRECT ANSWER B
7. A 36-year-old man is admitted to the hospital for a severe methicillin-resistant Staphylococcus aureus diabetic foot
infection and is started on linezolid 600 mg IV every 12 hours. His medication profile includes paroxetine 40 mg
every morning, trazodone 100 mg at bedtime as needed for sleep, and metformin 1000 mg po twice daily. After 3
days on these medications, the patient becomes agitated, confused, and di- aphoretic and develops myoclonic jerks
Which of the following is the most likely diagnosis?
A. Overdose of metformin
B. Bacterial meningitis
C. Neuroleptic malignant syndrome
D. Serotonin syndrome 🗸🗸 CORRECT ANSWER D
8. A 46-year-old woman presents to the psychiatric outpatient clinic for fol- low-up treatment of major
depression. She is currently on paroxetine 10 mg at bedtime, which she started taking 2 months ago when
admitted to the psychiatric hospital for suicidal ideation. During the interview, she says that she
