NSG 533 Advanced Pharmacology Test 1 Week 4
Study online at https://quizlet.com/_a4rogg
1. Which of the following SSRIs requires up to a 5-week washout period because
of the
long half-life of its potent active metabolite?
A. Escitalopram
B. Fluvoxamine
C. Fluoxetine
D. Sertraline: C
2. Which of the following symptoms is most likely to improve within approxi-
mately 1 week
of starting treatment?
A. Depressed mood
B. Suicidal thoughts
C. Anhedonia
D. Sleep: D
3. Of the following combinations of medications, which one would you want to
avoid?
A. Fluoxetine-lithium
B. Fluoxetine-phenelzine
C. Citalopram-valproic acid
D. Citalopram-aripiprazole: B
4. A 26-year-old man with a history of depression has been taking sertraline 200
mg/day for 12 weeks with no response. The patient has no other complications.
The physician asks for your recommendation. The most reasonable recommen-
dation would be to:
A. Increase sertraline
B. Add fluoxetine
C. Switch to amitriptyline
D. Change to venlafaxine
E. Decrease sertraline: D
5. Which of the following is a dangerous combination?
A. MAOI-lorazepam
B. MAOI-acetaminophen
, NSG 533 Advanced Pharmacology Test 1 Week 4
Study online at https://quizlet.com/_a4rogg
C. MAOI-meperidine
D. MAOI-ziprasidone: C
6. A 23-year-old married white woman comes to the outpatient psychiatric
clinic
complaining of decreased sleep, decreased appetite, decreased concentration,
depressed
mood, thoughts of death, and lack of interest in activities for 6 weeks' duration.
She has
no history of psychiatric illness and takes no medications except for Ortho-Tri
Cyclen Lo
daily. Based upon the patients symptoms, choose the best medication to treat
this patient.
A. Nefazodone 100 mg po twice daily
B. Paroxetine 20 mg po daily
C. St. John's wort 300 mg po three times daily
D. Amitriptyline 25 mg at bedtime: B
7. A 36-year-old man is admitted to the hospital for a severe methicillin-resistant
Staphylococcus aureus diabetic foot infection and is started on linezolid 600
mg IV every 12 hours. His medication profile includes paroxetine 40 mg every
morning, trazodone 100 mg at bedtime as needed for sleep, and metformin
1000 mg po twice daily. After 3
days on these medications, the patient becomes agitated, confused, and di-
aphoretic and develops myoclonic jerks. Which of the following is the most
likely diagnosis?
A. Overdose of metformin
B. Bacterial meningitis
C. Neuroleptic malignant syndrome
D. Serotonin syndrome: D
8. A 46-year-old woman presents to the psychiatric outpatient clinic for fol-
low-up treatment of major depression. She is currently on paroxetine 10 mg
at bedtime, which she started taking 2 months ago when admitted to the
psychiatric hospital for suicidal ideation. During the interview, she says that she
Study online at https://quizlet.com/_a4rogg
1. Which of the following SSRIs requires up to a 5-week washout period because
of the
long half-life of its potent active metabolite?
A. Escitalopram
B. Fluvoxamine
C. Fluoxetine
D. Sertraline: C
2. Which of the following symptoms is most likely to improve within approxi-
mately 1 week
of starting treatment?
A. Depressed mood
B. Suicidal thoughts
C. Anhedonia
D. Sleep: D
3. Of the following combinations of medications, which one would you want to
avoid?
A. Fluoxetine-lithium
B. Fluoxetine-phenelzine
C. Citalopram-valproic acid
D. Citalopram-aripiprazole: B
4. A 26-year-old man with a history of depression has been taking sertraline 200
mg/day for 12 weeks with no response. The patient has no other complications.
The physician asks for your recommendation. The most reasonable recommen-
dation would be to:
A. Increase sertraline
B. Add fluoxetine
C. Switch to amitriptyline
D. Change to venlafaxine
E. Decrease sertraline: D
5. Which of the following is a dangerous combination?
A. MAOI-lorazepam
B. MAOI-acetaminophen
, NSG 533 Advanced Pharmacology Test 1 Week 4
Study online at https://quizlet.com/_a4rogg
C. MAOI-meperidine
D. MAOI-ziprasidone: C
6. A 23-year-old married white woman comes to the outpatient psychiatric
clinic
complaining of decreased sleep, decreased appetite, decreased concentration,
depressed
mood, thoughts of death, and lack of interest in activities for 6 weeks' duration.
She has
no history of psychiatric illness and takes no medications except for Ortho-Tri
Cyclen Lo
daily. Based upon the patients symptoms, choose the best medication to treat
this patient.
A. Nefazodone 100 mg po twice daily
B. Paroxetine 20 mg po daily
C. St. John's wort 300 mg po three times daily
D. Amitriptyline 25 mg at bedtime: B
7. A 36-year-old man is admitted to the hospital for a severe methicillin-resistant
Staphylococcus aureus diabetic foot infection and is started on linezolid 600
mg IV every 12 hours. His medication profile includes paroxetine 40 mg every
morning, trazodone 100 mg at bedtime as needed for sleep, and metformin
1000 mg po twice daily. After 3
days on these medications, the patient becomes agitated, confused, and di-
aphoretic and develops myoclonic jerks. Which of the following is the most
likely diagnosis?
A. Overdose of metformin
B. Bacterial meningitis
C. Neuroleptic malignant syndrome
D. Serotonin syndrome: D
8. A 46-year-old woman presents to the psychiatric outpatient clinic for fol-
low-up treatment of major depression. She is currently on paroxetine 10 mg
at bedtime, which she started taking 2 months ago when admitted to the
psychiatric hospital for suicidal ideation. During the interview, she says that she
