adults
b. most older adults have decreased
1. Which factor is a major body fat and in- creased lean mass
pharmacokinetic process? c. renal function declines with age,
leading to de- creased drug
a. physiologic interactions
excretion
of drugs
d. hepatic metabolism tends to
b. interactions among vari-
increase in old- er adults, resulting in
ous drugs
de- creased drug levels
c. adverse reactions to
drugs
d. absorption of drugs
2. Which statement repre-
sents a physiologic change
that may alter pharmaco-
dynamics in older adults
prescribed multiple med-
ications?
a. the % of drug absorbed
often is decreased in older
, Elsevier Pharmacology Exam 1 Practice Questions.
d. absorption of drugs
Pharmacokinetics involves the way the drug
moves through the body, including absorption,
distribution, metabolism, and excre- tion
c. renal function declines with age, leading to
decreased drug excretion
Although absorption may be delayed in older
adults, the % ab- sorbed does not change.
Most older adults have increased body fat and
decreased lean mass. Hepatic metabolism tends
to decline with age.
, Elsevier Pharmacology Exam 1 Practice Questions.
3. Which term refers to the c. pharmacodynamics
study of how the adminis-
Pharmacodynamics studies what drugs do to the body (how they
tration of a drug influences
influence cellular physiology)
cell physiology?
a. pharmacology
b. pharmacokinetics
c. pharmacodynamics
d. pharmacotherapeutics
4. Which phase of pharmaco- d. excretion
kinetics is of the greatest
concern for the nurse when Although pharmacokinetic changes in older adults attect all phas-
assessing for drug effects es of pharmacokinetics, drug accumulation secondary to reduce
in older adults? renal excretion is the most important cause of adverse drug reac-
tions in older adults
a. absorption
b. distribution
c. metabolism
d. excretion
5. What is the correct or- 4. absportion
der of the pharmacokinet- 2. distribution
ic processes for parenteral 1. biotransformation
drugs? 3. elimination
1. biotransformation The first step in the process of pharmacokinetics is absorption.
2. distribution The drug moves from the GI tract to body fluids by passive ab-
3. elimination sorption, active absorption, or pinocytosis. The absorbed drug
4. absorption is distributed by blood flow, the tissue's aflnity for the drug,
and the protein-binding ettect. The distributed drug undergoes
metabolism or biotransformation in various organs of the body,
, Elsevier Pharmacology Exam 1 Practice Questions.
but the liver is the primary site of metabolism.
The kidney filter