ANCC Domain 1-5 Exam Questions
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2025/2026 Syllabus||Already Graded
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Which of the following interventions have evidence-based findings to reduce co-
morbid substance use in patients with schizophrenia?
A. Manualized group intervention with motivational enhancement
B. Voucher-based behavioral reinforcement
C. Three-session individual motivational enhancement
D. Psychosocial support group targeting coping skills - ANSWER ✓ A.
Manualized group intervention with motivational enhancement
Your 37 y/o female patient suffers from schizophrenia. She has been maintained
in stable condition for four years on Quetiapine (Seroquel). She tells you that her
gynecologist has recommended that she have a total hysterectomy. You asked her
is her gynecologist plans to prescribe hormone replacement after the total
hysterectomy. She responds "no". You initiate a call to the gynecologist to discuss
hormone replacement therapy as follows:
A. You want to know if the gynecologist will wean the patient off her own
estrogen. By suppressing the ovaries, she can be tapered off her own estrogen
before the surgery
B. The abrupt loss of estrogen from the ovaries can precipitate deterioration of
mental state, hallucinations, delusions, and depression as well as the stress from
surgical menopause
C. Consultation with the gynecologist is not needed. The patient can adapt to
surgical menopause as easily as she would natural menopau - ANSWER ✓ B. The
abrupt loss of estrogen from the ovaries can precipitate deterioration of mental
state, hallucinations, delusions, and depression as well as the stress from surgical
menopause
Electroconvulsive therapy (ECT) is a treatment for depression. What adverse
effect is uncommon for a patient to experience after receiving ECT treatments?
A. headaches
,B. muscle soreness
C. memory disturbance
D. fractures - ANSWER ✓ D. fractures
Risk reduction for a 22 y/o patient with schizophrenia taking olanzapine includes
patient education on daily exercise, balanced nutrition, and baseline and periodic
monitoring of BP, weight, BMI, and:
A. Fasting glucose, fasting lipid panel, electrolytes
B. Waist circumference, fasting lipid panel, EKG, prolactin level
C. Waist circumference, fasting glucose, fasting lipid panel
D. Fasting lipid panel, EKG, liver enzymes - ANSWER ✓ C. Waist circumference,
fasting glucose, fasting lipid panel
Which of the following lab findings would raise the greatest concern when
prescribing Lithium?
A. Serum Na+ 120 mEq/L
B. Glomerular Filtration Rate (GFR) 115 mL/min
C. Serum Creatinine 3.0 mg/dL
D. Blood Urea Nitrogen (BUN) 20 mg/dL - ANSWER ✓ C. Serum Creatinine 3.0
mg/dL
For a patient who has a long history of opiate dependence and is newly in
recovery, which of the following is most likely to aid in the treatment process?
A. Acamprosate (Campral)
B. Buprenorphine (Buprenex)
C. Varenicline (Chantix)
D. Bupropion (Wellbutrin) - ANSWER ✓ B. Buprenorphine (Buprenex)
A Psychiatric-Mental Health Nurse Practitioner treating a 32 y/o woman after
hospitalization for postpartum psychosis after the birth of her first child needs to
consider which as the most important risk factor when monitoring her response to
treatment?
A. Subsequent pregnancies are associated with increased risk of another episode,
as high as 50 percent
B. Incidence of postpartum psychosis is about 1 to 2 per 1,000 childbirths and 50
to 60 percent of affected women have just had their first child
C. As many as two thirds of patient have a second episode of an underlying
affective disorder during the year after the baby's births
,D. Data suggest that an episode of postpartum psychosis is essentially an episode
of a mood disorder, and is usually an indicator of bipolar disorder - ANSWER ✓
D. Data suggest that an episode of postpartum psychosis is essentially an episode
of a mood disorder, and is usually an indicator of bipolar disorder
When evaluating a 5 y/o child with language deficits, which of the following is a
key indicator in differentiating autistic disorder from a mixed receptive-expressive
language disorder?
A. Family history of speech delay or language problems
B. Level of intelligence ranges from mild to severe impairment
C. Language abnormalities such as echolalia are common
D. Imaginative play is predominant form of expression - ANSWER ✓ C. Language
abnormalities such as echolalia are common
A new patient comes to you on a medication regimen of: Adderall XR 30mg 1 PO
QAM, Seroquel 300 mg PO QHS, Mirtazapine 45 mg PO QHS, Diazepam 5 mg
PO TID, Zolpidem 10 mg PO QHS, and Zolpidem 10 mg PO QHS in addition if
initial dose does not help the patient sleep. You confirm the medication regimen
with the patient's past records. You diagnose the patient with Post Traumatic Stress
disorder, Panic Disorder, Major Depressive Disorder, Attention Deficit Disorder,
and Alcohol Use Disorder-moderate by history in recovery. You treat the patient
and find that the patient is resistant to changing the past medication regimen. The
patient calls you stating that the pharmacy will not refill the Zolpidem at this time.
The patient wants you to rewrite the script so that the medication is available. In
checking with the pharmacy, you find out that the patient has potentially used 60
tablets of Zolpidem in a 20 day period. Your bes - ANSWER ✓ C. Discontinue the
prescription for the Zolpidem. Talk to the patient about the overuse of Zolpidem
and the danger it poses to his health and wellbeing.
In distinguishing between dementia and pseudodementia which of the following
findings would be expected in a patient with pseudodementia?
A. Attention and concentration usually faulty
B. Nocturnal accentuation of dysfunction common
C. Struggle to perform tasks
D. "Don't know" answers typical - ANSWER ✓ D. "Don't know" answers typical
An 8 y/o boy is referred to you by his school nurse because he has been
complaining of stomachaches every morning in school for the past month. When
interviewing the boy's mother, she states that he does not like to go to school,
, insists on coming home immediately after school, and sleeps with his parents at
night. The mother denies any other complaints. Which of the following is the most
likely diagnosis?
A. Social phobia
B. Posttraumatic stress disorder
C. Separation anxiety disorder
D. Reactive attachment disorder - ANSWER ✓ C. Separation anxiety disorder
Which of the following interventions does not have evidence-based findings that
demonstrate reduced symptoms in individuals with non-combat related
posttraumatic stress disorder (PTSD)?
A. Selective serotonin reuptake inhibitors (SSRIs)
B. Exposure-based cognitive behavioral therapy (CBT)
C. Anticonvulsants
D. Eye-movement, desensitization, and reprocessing (EMDR) - ANSWER ✓ C.
Anticonvulsants
When evaluating a woman with major depressive disorder, which of the following
would not be a major consideration in the differential diagnosis?
A. Prior episodes of depression
B. Any periods without sleep yet no fatigue
C. Any episodes of hypomania
D. Prior pregnancies - ANSWER ✓ D. Prior pregnancies
Clozapine is associated with sever neutropenia (absolute neutrophil count (ANC)
less than 500/L). The requirements to prescribe, dispense, and receive Clozapine
are incorpated into a single, shared program called the Clozapine Risk Evaluation
and Mitigation Strategy (REMS). Who implements the Clozapine Risk Evaluation
and Mitigation Strategy (REMS)?
A. The manufacturers of Clozapine (Clozaril)
B. Health and Human Services (HHS)
C. A Federal Drug Administration (FDA)
D. Center for Disease Control and Prevention (CDC) - ANSWER ✓ A. The
manufacturers of Clozapine (Clozaril)
You have a 16 y/o patient who suffers from Binge Eating Disorder. She is 5ft 10
in tall (70 inches) at has a BMI of 30. You consult the National Guideline Clearing
House for the best information on treating the patient. Part of your treatment plan
includes:
with Correct Solutions|| Updated
2025/2026 Syllabus||Already Graded
100% Guaranteed Pass!!!<<Brand
New Version>>
Which of the following interventions have evidence-based findings to reduce co-
morbid substance use in patients with schizophrenia?
A. Manualized group intervention with motivational enhancement
B. Voucher-based behavioral reinforcement
C. Three-session individual motivational enhancement
D. Psychosocial support group targeting coping skills - ANSWER ✓ A.
Manualized group intervention with motivational enhancement
Your 37 y/o female patient suffers from schizophrenia. She has been maintained
in stable condition for four years on Quetiapine (Seroquel). She tells you that her
gynecologist has recommended that she have a total hysterectomy. You asked her
is her gynecologist plans to prescribe hormone replacement after the total
hysterectomy. She responds "no". You initiate a call to the gynecologist to discuss
hormone replacement therapy as follows:
A. You want to know if the gynecologist will wean the patient off her own
estrogen. By suppressing the ovaries, she can be tapered off her own estrogen
before the surgery
B. The abrupt loss of estrogen from the ovaries can precipitate deterioration of
mental state, hallucinations, delusions, and depression as well as the stress from
surgical menopause
C. Consultation with the gynecologist is not needed. The patient can adapt to
surgical menopause as easily as she would natural menopau - ANSWER ✓ B. The
abrupt loss of estrogen from the ovaries can precipitate deterioration of mental
state, hallucinations, delusions, and depression as well as the stress from surgical
menopause
Electroconvulsive therapy (ECT) is a treatment for depression. What adverse
effect is uncommon for a patient to experience after receiving ECT treatments?
A. headaches
,B. muscle soreness
C. memory disturbance
D. fractures - ANSWER ✓ D. fractures
Risk reduction for a 22 y/o patient with schizophrenia taking olanzapine includes
patient education on daily exercise, balanced nutrition, and baseline and periodic
monitoring of BP, weight, BMI, and:
A. Fasting glucose, fasting lipid panel, electrolytes
B. Waist circumference, fasting lipid panel, EKG, prolactin level
C. Waist circumference, fasting glucose, fasting lipid panel
D. Fasting lipid panel, EKG, liver enzymes - ANSWER ✓ C. Waist circumference,
fasting glucose, fasting lipid panel
Which of the following lab findings would raise the greatest concern when
prescribing Lithium?
A. Serum Na+ 120 mEq/L
B. Glomerular Filtration Rate (GFR) 115 mL/min
C. Serum Creatinine 3.0 mg/dL
D. Blood Urea Nitrogen (BUN) 20 mg/dL - ANSWER ✓ C. Serum Creatinine 3.0
mg/dL
For a patient who has a long history of opiate dependence and is newly in
recovery, which of the following is most likely to aid in the treatment process?
A. Acamprosate (Campral)
B. Buprenorphine (Buprenex)
C. Varenicline (Chantix)
D. Bupropion (Wellbutrin) - ANSWER ✓ B. Buprenorphine (Buprenex)
A Psychiatric-Mental Health Nurse Practitioner treating a 32 y/o woman after
hospitalization for postpartum psychosis after the birth of her first child needs to
consider which as the most important risk factor when monitoring her response to
treatment?
A. Subsequent pregnancies are associated with increased risk of another episode,
as high as 50 percent
B. Incidence of postpartum psychosis is about 1 to 2 per 1,000 childbirths and 50
to 60 percent of affected women have just had their first child
C. As many as two thirds of patient have a second episode of an underlying
affective disorder during the year after the baby's births
,D. Data suggest that an episode of postpartum psychosis is essentially an episode
of a mood disorder, and is usually an indicator of bipolar disorder - ANSWER ✓
D. Data suggest that an episode of postpartum psychosis is essentially an episode
of a mood disorder, and is usually an indicator of bipolar disorder
When evaluating a 5 y/o child with language deficits, which of the following is a
key indicator in differentiating autistic disorder from a mixed receptive-expressive
language disorder?
A. Family history of speech delay or language problems
B. Level of intelligence ranges from mild to severe impairment
C. Language abnormalities such as echolalia are common
D. Imaginative play is predominant form of expression - ANSWER ✓ C. Language
abnormalities such as echolalia are common
A new patient comes to you on a medication regimen of: Adderall XR 30mg 1 PO
QAM, Seroquel 300 mg PO QHS, Mirtazapine 45 mg PO QHS, Diazepam 5 mg
PO TID, Zolpidem 10 mg PO QHS, and Zolpidem 10 mg PO QHS in addition if
initial dose does not help the patient sleep. You confirm the medication regimen
with the patient's past records. You diagnose the patient with Post Traumatic Stress
disorder, Panic Disorder, Major Depressive Disorder, Attention Deficit Disorder,
and Alcohol Use Disorder-moderate by history in recovery. You treat the patient
and find that the patient is resistant to changing the past medication regimen. The
patient calls you stating that the pharmacy will not refill the Zolpidem at this time.
The patient wants you to rewrite the script so that the medication is available. In
checking with the pharmacy, you find out that the patient has potentially used 60
tablets of Zolpidem in a 20 day period. Your bes - ANSWER ✓ C. Discontinue the
prescription for the Zolpidem. Talk to the patient about the overuse of Zolpidem
and the danger it poses to his health and wellbeing.
In distinguishing between dementia and pseudodementia which of the following
findings would be expected in a patient with pseudodementia?
A. Attention and concentration usually faulty
B. Nocturnal accentuation of dysfunction common
C. Struggle to perform tasks
D. "Don't know" answers typical - ANSWER ✓ D. "Don't know" answers typical
An 8 y/o boy is referred to you by his school nurse because he has been
complaining of stomachaches every morning in school for the past month. When
interviewing the boy's mother, she states that he does not like to go to school,
, insists on coming home immediately after school, and sleeps with his parents at
night. The mother denies any other complaints. Which of the following is the most
likely diagnosis?
A. Social phobia
B. Posttraumatic stress disorder
C. Separation anxiety disorder
D. Reactive attachment disorder - ANSWER ✓ C. Separation anxiety disorder
Which of the following interventions does not have evidence-based findings that
demonstrate reduced symptoms in individuals with non-combat related
posttraumatic stress disorder (PTSD)?
A. Selective serotonin reuptake inhibitors (SSRIs)
B. Exposure-based cognitive behavioral therapy (CBT)
C. Anticonvulsants
D. Eye-movement, desensitization, and reprocessing (EMDR) - ANSWER ✓ C.
Anticonvulsants
When evaluating a woman with major depressive disorder, which of the following
would not be a major consideration in the differential diagnosis?
A. Prior episodes of depression
B. Any periods without sleep yet no fatigue
C. Any episodes of hypomania
D. Prior pregnancies - ANSWER ✓ D. Prior pregnancies
Clozapine is associated with sever neutropenia (absolute neutrophil count (ANC)
less than 500/L). The requirements to prescribe, dispense, and receive Clozapine
are incorpated into a single, shared program called the Clozapine Risk Evaluation
and Mitigation Strategy (REMS). Who implements the Clozapine Risk Evaluation
and Mitigation Strategy (REMS)?
A. The manufacturers of Clozapine (Clozaril)
B. Health and Human Services (HHS)
C. A Federal Drug Administration (FDA)
D. Center for Disease Control and Prevention (CDC) - ANSWER ✓ A. The
manufacturers of Clozapine (Clozaril)
You have a 16 y/o patient who suffers from Binge Eating Disorder. She is 5ft 10
in tall (70 inches) at has a BMI of 30. You consult the National Guideline Clearing
House for the best information on treating the patient. Part of your treatment plan
includes:
