MCB4271 Final Exam, MCB4271 Test Bank, Molecular and Cell Biology, MCB4271
Questions and Answers, Advanced Biology Exam, MCB4271 Study Guide, Biology Final
Exam Prep
DNA Disrupt - (answer)Metronidazole
DNA gyrase - (answer)Quinolones target type II topoisomerases (DNA synth gyrase and topo IV)
Novobiocin
tRNA - (answer)Mupirocin
RNA Polymerase - (answer)Rifamycin
Erythromycin (Anasamycins)
Protein Synth: 50s - (answer)Lincosanides
Macrolides
Chlorophenicol
Oxazolidinones (cycloserine)
Streptogramins
Protein synth: 30s - (answer)aminoglycosides
tetracyclines
Folic Acid Synthesis Inhibitors - (answer)Sulfonamides- DHP synthesis
Trimethoprim- DHPR
Cell wall synthesis inhibitors - (answer)Beta-lactams (PCN, cephalosporin, carbapenems, monobactames,
clavams)
glycopeptides (vanco)
, MCB4271 Final Exam, MCB4271 Test Bank, Molecular and Cell Biology, MCB4271
Questions and Answers, Advanced Biology Exam, MCB4271 Study Guide, Biology Final
Exam Prep
Peptidoglycan synth: Cycloserine, bacitracin
Cell Membrane Function Inhibitor - (answer)Antibacterial: polymixin, daptomycin
Antifungal: Amphoterian B, Nystatin, Terbinafine, Azoles
AMR mechanisms Mutations - (answer)Rifampicin- point mut in rpoB coding for beta subunit or RNA
polymerase
Fluoroquinolones- mut in QRDR of GyrA & ParC/GrlA
Trimethoprim- mut in chromosome gene DHFR
AMR Mechanisms Horizontal Gene Transfer - (answer)Methicillin- acq MecA gene by MRSA
Sulfonamide- acq foreign folP gene
Vanco- acq vanA& vanB gene
AMR Mechanisms - (answer)PCN- inactivated by betalactamases, abx efflux pumps on G-
Cephalosporin- same as PCN
Carbapenems- resist hydrolysis by beta lactamases
viral integrase inhibitors - (answer)Drugs that inhibit the action of the HIV integrase, so that the virus
cannot integrate into the host cell genome.
- usese: genetic inj, membrane fusion, endocytosis
Drug target modification - (answer)protease inhibitors
integrase inhibitors
nucleoside analogs
reverse transcriptase inhibitors
Questions and Answers, Advanced Biology Exam, MCB4271 Study Guide, Biology Final
Exam Prep
DNA Disrupt - (answer)Metronidazole
DNA gyrase - (answer)Quinolones target type II topoisomerases (DNA synth gyrase and topo IV)
Novobiocin
tRNA - (answer)Mupirocin
RNA Polymerase - (answer)Rifamycin
Erythromycin (Anasamycins)
Protein Synth: 50s - (answer)Lincosanides
Macrolides
Chlorophenicol
Oxazolidinones (cycloserine)
Streptogramins
Protein synth: 30s - (answer)aminoglycosides
tetracyclines
Folic Acid Synthesis Inhibitors - (answer)Sulfonamides- DHP synthesis
Trimethoprim- DHPR
Cell wall synthesis inhibitors - (answer)Beta-lactams (PCN, cephalosporin, carbapenems, monobactames,
clavams)
glycopeptides (vanco)
, MCB4271 Final Exam, MCB4271 Test Bank, Molecular and Cell Biology, MCB4271
Questions and Answers, Advanced Biology Exam, MCB4271 Study Guide, Biology Final
Exam Prep
Peptidoglycan synth: Cycloserine, bacitracin
Cell Membrane Function Inhibitor - (answer)Antibacterial: polymixin, daptomycin
Antifungal: Amphoterian B, Nystatin, Terbinafine, Azoles
AMR mechanisms Mutations - (answer)Rifampicin- point mut in rpoB coding for beta subunit or RNA
polymerase
Fluoroquinolones- mut in QRDR of GyrA & ParC/GrlA
Trimethoprim- mut in chromosome gene DHFR
AMR Mechanisms Horizontal Gene Transfer - (answer)Methicillin- acq MecA gene by MRSA
Sulfonamide- acq foreign folP gene
Vanco- acq vanA& vanB gene
AMR Mechanisms - (answer)PCN- inactivated by betalactamases, abx efflux pumps on G-
Cephalosporin- same as PCN
Carbapenems- resist hydrolysis by beta lactamases
viral integrase inhibitors - (answer)Drugs that inhibit the action of the HIV integrase, so that the virus
cannot integrate into the host cell genome.
- usese: genetic inj, membrane fusion, endocytosis
Drug target modification - (answer)protease inhibitors
integrase inhibitors
nucleoside analogs
reverse transcriptase inhibitors
