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1. Which of the following best defines a neoplasm?
A. A scar tissue formed after injury
B. An abnormal mass of tissue formed by excessive cell growth
C. A normal tissue adaptation to stress
D. A reversible cellular change due to injury
Correct Answer: B
Rationale: A neoplasm is an abnormal mass of tissue that forms when cells
proliferate excessively or fail to undergo normal cell death. Unlike normal
adaptations, it is uncontrolled and can be benign or malignant.
2. The Frank-Starling mechanism explains which cardiac concept?
A. The heart rate increases with vagal stimulation
B. Stroke volume increases with greater ventricular filling
C. Blood pressure is maintained despite blood loss
D. Calcium directly increases myocardial relaxation
Correct Answer: B
Rationale: The Frank-Starling law states that the greater the volume of blood
filling the ventricles (end-diastolic volume), the stronger the contraction, leading
to increased stroke volume.
,3. Cardiac reserve refers to:
A. The maximum volume of blood stored in the left ventricle
B. The ability of the heart to increase output above resting levels
C. The amount of blood remaining after systole
D. The venous return to the heart during inspiration
Correct Answer: B
Rationale: Cardiac reserve is the difference between resting cardiac output and
maximum cardiac output during stress or exercise. Low reserve indicates cardiac
dysfunction.
4. Which factor directly increases preload?
A. Increased venous return
B. Elevated systemic vascular resistance
C. Sympathetic blockade
D. Pulmonary hypertension
Correct Answer: A
Rationale: Preload is determined by venous return and ventricular filling.
Increased blood volume or venous tone raises preload. Pulmonary hypertension
affects right-sided afterload, not preload.
5. Pulmonary arterial pressure primarily contributes to:
A. Preload of the left heart
B. Afterload of the right heart
C. Contractility of the left ventricle
D. Stroke volume of the right atrium
Correct Answer: B
Rationale: Pulmonary arterial pressure is the main source of afterload on the right
ventricle, since it represents the resistance the right heart must overcome to eject
blood.
,6. Cardiac contractility is most strongly influenced by:
A. Sodium channel activity
B. Calcium ion availability in myocardial cells
C. Venous capacitance
D. Parasympathetic stimulation
Correct Answer: B
Rationale: Contractility depends on calcium entry and cycling within cardiac
muscle. Increased calcium availability enhances actin-myosin cross-bridge
formation, raising contractility.
7. Which formula correctly represents cardiac output (CO)?
A. CO = HR × PR
B. CO = HR × SV
C. CO = SV ÷ HR
D. CO = MAP × SVR
Correct Answer: B
Rationale: Cardiac output is the product of stroke volume (SV) and heart rate
(HR). Mean arterial pressure (MAP) and systemic vascular resistance (SVR)
describe blood pressure, not CO.
8. Which chamber of the heart receives deoxygenated blood from the vena
cava?
A. Left atrium
B. Left ventricle
C. Right atrium
D. Right ventricle
, Correct Answer: C
Rationale: The right atrium collects deoxygenated blood from the systemic
circulation via the superior and inferior vena cava.
9. The valve located between the left atrium and left ventricle is called the:
A. Tricuspid valve
B. Pulmonary valve
C. Mitral (bicuspid) valve
D. Aortic valve
Correct Answer: C
Rationale: The mitral (or bicuspid) valve regulates blood flow from the left atrium
into the left ventricle.
10. Correct order of blood flow through the heart is:
A. Right atrium → Mitral valve → Right ventricle → Lungs
B. Left atrium → Aortic valve → Left ventricle → Pulmonary artery
C. Right atrium → Tricuspid valve → Right ventricle → Pulmonary artery
D. Left ventricle → Pulmonary valve → Pulmonary vein → Right atrium
Correct Answer: C
Rationale: The right atrium receives venous blood → passes through tricuspid
valve → right ventricle → pulmonary valve → pulmonary artery → lungs.
11. Which structure in the brainstem contains autonomic control centers for
cardiac function?
A. Pons
B. Hypothalamus
C. Medulla oblongata
D. Midbrain