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1. Neurofibromatosis - ANSWER genetic disorder that causes tumors to
develop from Schwann cells of neurologic system
2. Type 1 neurofibromatosis characteristics - ANSWER cutaneous and
subcutaneous lesions, cafe-au-lait spots (at least 6 at birth), freckles,
scoliosis, erosive bone defects, neurologic complications (learning
disabilities, ADD, abnormalities of speech, seizures)
3. Type 2 neurofibromatosis characteristics - ANSWER tumors of the
acoustic nerve (headaches, hearing loss, tinnitus)
4. Phenylketonuria - ANSWER PKU - rare autosomal recessive metabolic
disorder which allows toxic levels of amino acid phenylalanine to
accumulate in tissues and blood
- all infants are screened for abnormal levels of this
5. Effects of PKU - ANSWER untreated PKU leads to mental retardation,
microcephaly, delayed speech, impaired neurological development
,6. Treatment of PKU - ANSWER special diet that restricts phenylalanine
intake (must be started as a neonate (7-10 days) to prevent brain damage)
7. Tay-Sachs disease - ANSWER lysosomal storage disease (gangliosidoses)
- failure to break down GM2 gangliosides of cell membrane, causing
accumulation in all organs (prominent in brain neurons and retina) that
leads to progressive destruction of neurons, including the cerebellum, basal
ganglia, brain stem, spinal cord, and autonomic NS
8. Physical exam finding with tay-sachs - ANSWER cherry red spot on
macula
9. How does tay-sachs present - ANSWER infants appear normal at birth
but manifest progressive weakness, muscle flaccidity, and decreased
responsiveness at 6-10 months, followed by rapid deterioration of motor
and mental functioning (leads to seizures, blindness, death by age 4-5)
10.Tay Sach's pattern of inheritance - ANSWER autosomal recessive
11.Types of cells in nervous tissue
- ANSWER neurons and neuroglia
12.Neurons
- ANSWER · Functional cells of nervous system
· Exhibit excitability and conduct impulses for nervous system to
function
,13.what kind of nervous tissue cell requires a constant oxygen and glucose
supply?
- ANSWER neurons
14.what are neurons vulnerable to?
- ANSWER hypoxia and hypoglycemia
15.Consequences of unmet demand with nervous tissue
- ANSWER there could be an interruption in blood or oxygen to the
brain
16.what can interrupted blood flow can lead to with nervous tissue?
- ANSWER to metabolic byproducts which are toxic to neural tissue
headache
difficult to dx
need detailed history- food, meds, daily routine, etc
17.3 types of thermal sensation receptors
- ANSWER cold, warmth, pain
18.where are cold and warmth receptors located?
- ANSWER directly under skin
· Nociceptive
- ANSWER activated in response to actual or impending tissue
injury.
19.neuropathic
- ANSWER originates from pathology of chronic condition
20.tigeminal neuralgia
- ANSWER Facial tics or spasms and characterized by paroxysmal
attacks of stabbing pain
21.post therapeutic neuralgia
- ANSWER pain from shingles/ herpes
22.complex regional pain
- ANSWER Autonomic and vasomotor instability
23.phantom limb syndrome
, - ANSWER Follows amputation of a limb or part of a limb
24.what type of pain is phantom limb syndrome
- ANSWER neuropathic
25.Myasthenia Gravis
- ANSWER Disorder of transmission at the neuromuscular junction
26.Myasthenia gravis patho
- ANSWER Antibody mediated attack on nicotinic acetylcholine
receptor or muscle specific tyrosine kinase (MuSK)
27.Myasthenia gravis affects communication between what?
- ANSWER · motor neuron and the innervated muscle
28.Multiple Sclerosis
- ANSWER Demyelinating disorder
Inflammation and destruction of white matter of CNS myelin
- ANSWER when is onset of MS
20-30 yo
29.Is MS more common in male or female
- ANSWER twice as more common in females
30.Does MS affect the CNS or PNS?
- ANSWER CNS
common areas MS affects
- ANSWER optic nerve
· Corticobulbar tracts
corticospinal
cerebellar
· Medial longitudinal fasciculus
· Posterior cell columns of spinal cord
Corticobulbar tracts
- ANSWER speech and swallowing