h
Introduction to Genetic Analysis
h h h
Anthony J.F. Griffiths, John Doebley, Catherine Peichel, and David A. Wassarman
h h h h h h h h h h
12th Edition
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,Table of Contents
h h
Chapterh01hThehGeneticshRevolution 1
Chapterh02hSinglehGenehInheritance 6
Chapterh03hIndependenthAssortmenthofhGenes 26
Chapterh04hMappinghEukaryotehChromosomeshbyhRecombination 43
Chapterh05hGenehInteraction 63
Chapterh06hThehGeneticshofhBacteriahandhTheirhViruses 84
Chapterh07hDNAhStructurehandhReplication 104
Chapterh08hRNAhTranscriptionhProcessinghandhDecay 117
Chapterh09hProteinshandhTheirhSynthesis 130
Chapterh10hGenehIsolationhandhManipulation 141
Chapterh11hRegulationhofhGenehExpressionhinhBacteriahandhTheirhViruses 160
Chapterh12hRegulationhofhGenehExpressionhinhEukaryotes 175
Chapterh13hThehGenetichControlhofhDevelopment 184
Chapterh14hGenomeshandhGenomics 192
Chapterh15hDNAhDamagehRepairhandhRecombination 197
Chapterh16hThehDynamichGenomehTransposablehElements 216
Chapterh17hLargehScalehChromosomalhChanges 225
Chapterh18hPopulationhGenetics 243
Chapterh19hThehInheritancehofhComplexhTraits 258
Chapterh20hEvolutionhofhGeneshandhTraits 270
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Chapterh01:hThehGeneticshRevolution
1. Thehearlyh1900shwashanhimportanthperiodhforhgeneticshduehtohwhichhofhthehfollowinghmajorhevents?
a. thehrediscoveryhofhGregorhMendel'shscientifichfindings
b. WatsonhandhCrickhsolvinghthehstructurehofhDNA
c. WalterhSuttonhandhTheodorehBoverihhypothesizinghthathchromosomesharehthehhereditaryhelements
d. thehrediscoveryhofhGregorhMendel'shscientifichfindingshandhWalterhSuttonhandhTheodorehBoverih
hypothesizinghthathchromosomesharehthehhereditaryhelements
e. Allhofhthehanswerhoptionsharehcorrect.
ANSWER:h e
2. Ahsamplehofhnormalhdouble-
strandedhDNAhwashfoundhtohhavehahguaninehcontenthofh18%.hWhathishthehexpectedhproportionhofhadenine?
a. 9%
b. 32%
c. 36%
d. 68%
e. 82%
ANSWER:h b
3. InhonehstrandhofhDNA,hthehnucleotidehsequencehish5'-ATGC-
3'.hThehcomplementaryhsequencehinhthehotherhstrandhmusthbe
a. 3'-ATGC-5'.
b. 3'-TACG-5'.
c. 5'-ATCG-3'.
d. 5'-CGTA-3'.
e. 5'-TACG-3'.
ANSWER:h b
4. HowhmanyhdifferenthDNAhmoleculeshthathareheight-nucleotide-pairshlongharehtheoreticallyhpossible?
a. 24
b. 32
c. 64
d. 256
e. 65,536
ANSWER:h e
5. Whichhofhthehfollowinghis/arehTRUEhabouthgenes?
a. Genesharehlocatedhonhchromosomes.
b. Geneshcomehinhvariantshknownhashalleles.
c. Geneshusuallyhencodehproteinhproducts.
d. Allhofhthehanswerhoptionsharehcorrect.
e. Nonehofhthehanswerhoptionshishcorrect.
ANSWER:h d
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6. Wildhcatsh(Felishsilvestris)handhcommonhmiceh(Mushmusculus)harehdiploid.hInhwildhcats,h2nh=h38,hwhilehinhc
ommonhmice,h2nh=h40.hBasedhonhthishinformation,hwehcanhconcludehthathwild-cathcellshhave
a. lesshDNAhthanhcommon-mousehcells.
b. smallerhgenomeshthanhcommon-mousehcells.
c. fewerhDNAhmoleculeshthanhcommon-mousehcells.
d. fewerhgeneshthanhcommon-mousehcells.
e. fewerhsetshofhchromosomeshthanhcommon-mousehcells.
ANSWER:h c
7. WhichhofhthehfollowinghishahcomponenthofhDNA?
a. alanine
b. arginine
c. cysteine
d. guanine
e. tyrosine
ANSWER:h d
8. Whichhofhthehfollowinghis/arehTRUEhofhthehDNAhstructurehsolvedhbyhWatsonhandhCrick?
a. Ithishahdouble-helicalhstructure.
b. Sugar–phosphatehbackbonehishalwayshtowardhthehoutsidehofhthehDNA.
c. ThereharehtwohhydrogenhbondshbetweenhAhandhThandhthreehhydrogenhbondshbetweenhChandhG.
d. Thereharehfourhtypeshofhnitrogenoushbases.
e. Allhofhthehanswerhoptionsharehcorrect.
ANSWER:h e
9. WhichhofhthehfollowinghishahCORRECThrepresentationhofhthehcentralhdogma?
a. RNAh→hDNAh→hprotein
b. proteinh→hDNAh→hRNA
c. DNAh→hRNAh→hprotein
d. DNAh→hproteinh→hDNA
e. Nonehofhthehanswerhoptionshishcorrect.
ANSWER:h c
10. Youhhavehcomehacrosshahdogh(namedhCindy)hthathdoeshnothhavehahtail.hInterestingly,hallhthehpuppieshproducedhb
yhthishdoghdon'thhavehahtail.hIfhthehlackhofhtailhishcausedhbyhahgenetichmutation,hwherehhashthishmutationhmosthlikelyht
akenhplace?
a. inhCindy'shgametes
b. inhthehcellshthathshouldhnormallyhhavehgivenhrisehtohCindy'shtail
c. inhthehcellshthathshouldhnormallyhhavehgivenhrisehtohCindy'shandhherhpuppies'htails
d. inhallhofhCindy'shcellsh(includinghherhgametes)
e. inhahgametehofhonehofhCindy'shparents
ANSWER:h a
11. Whichhofhthehfollowinghfeatureshmakeshahspecieshsuitablehashahmodelhorganism?
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