NRNP 6635 Final Exam - Schizophrenia
Study online at https://quizlet.com/_e2drrw
1. a psychological disorder characterized by delusions, Schizophrenia
hallucinations, disorganized speech, and/or dimin-
ished inappropriate emotional expression.
2. The signs and symptoms of schizophrenia are tradi- signs and symptoms of
tionally separated into 2 groups: positive (delusions, schizophrenia
hallucinations, and disorganized speech or behavior)
and negative (flat affect, avolition, anhedonia, poor
attention, and alogia).
3. a decline in both cognitive and social functioning that Schizophrenia is associat-
often precedes the development of florid psychosis. ed with
4. The exact etiology of schizophrenia is unknown, al- Etiology of Schizophrenia
though it is thought to be linked to an increase in
dopaminergic activity.
No single etiological factor is responsible for schizo-
phrenia.
5. Treatment includes antipsychotics in conjunction with Treatment of Schizophre-
behavioral therapy. nia
6. Schizophrenia is a chronic serious mental disorder Schizophrenia definition
characterized by loss of contact with reality and man-
ifested by two main symptoms: hallucinations and
delusions.
7. Men and women are equally affected, but with a slight onset of schizophrenia
difference in the age of onsetMen: average age of
onset = 23 years Women: average age of onset = 26
years
8.
, NRNP 6635 Final Exam - Schizophrenia
Study online at https://quizlet.com/_e2drrw
The disorder manifests when a person with a genetic Etiological factors of schiz-
predisposition is exposed to one of many environmen- ophrenia
tal stressors.
- genetic predisposition
- environmental stressors
9. Environmental stressors are believed to be triggers of Environmental Stressors of
schizophrenia rather than true causes of the disorder. Schizophrenia
-Childhood trauma
- Residence in an urban area
- Social isolation
-Frequent cannabis use in early adolescence
- Migration
- Poverty
- Stress and psychosocial factors
- Birth in late winter or early spring
-Advanced paternal age at conception
10. Genetic and environmental risk factors appear to act Pathophysiology of schizo-
via a common pathway phrenia part 1
of disrupting the function of 1 or more neurotransmit-
ter components.
Dopaminergic theory: Almost all drugs with antipsy-
chotic properties block the dopaminergic D2 receptor.
However, antipsychotics are only 70% effective and
clozapine, the most effective antipsychotic for treating
schizophrenia, is a weak D2 antagonist.
Hyperactivity of dopamine D2 receptor neurotransmis-
sion in subcortical, and limbic brain regions contribute
to the positive symptoms of schizophrenia. Hypo func-
tionality of dopamine D1 receptor neurotransmission
Study online at https://quizlet.com/_e2drrw
1. a psychological disorder characterized by delusions, Schizophrenia
hallucinations, disorganized speech, and/or dimin-
ished inappropriate emotional expression.
2. The signs and symptoms of schizophrenia are tradi- signs and symptoms of
tionally separated into 2 groups: positive (delusions, schizophrenia
hallucinations, and disorganized speech or behavior)
and negative (flat affect, avolition, anhedonia, poor
attention, and alogia).
3. a decline in both cognitive and social functioning that Schizophrenia is associat-
often precedes the development of florid psychosis. ed with
4. The exact etiology of schizophrenia is unknown, al- Etiology of Schizophrenia
though it is thought to be linked to an increase in
dopaminergic activity.
No single etiological factor is responsible for schizo-
phrenia.
5. Treatment includes antipsychotics in conjunction with Treatment of Schizophre-
behavioral therapy. nia
6. Schizophrenia is a chronic serious mental disorder Schizophrenia definition
characterized by loss of contact with reality and man-
ifested by two main symptoms: hallucinations and
delusions.
7. Men and women are equally affected, but with a slight onset of schizophrenia
difference in the age of onsetMen: average age of
onset = 23 years Women: average age of onset = 26
years
8.
, NRNP 6635 Final Exam - Schizophrenia
Study online at https://quizlet.com/_e2drrw
The disorder manifests when a person with a genetic Etiological factors of schiz-
predisposition is exposed to one of many environmen- ophrenia
tal stressors.
- genetic predisposition
- environmental stressors
9. Environmental stressors are believed to be triggers of Environmental Stressors of
schizophrenia rather than true causes of the disorder. Schizophrenia
-Childhood trauma
- Residence in an urban area
- Social isolation
-Frequent cannabis use in early adolescence
- Migration
- Poverty
- Stress and psychosocial factors
- Birth in late winter or early spring
-Advanced paternal age at conception
10. Genetic and environmental risk factors appear to act Pathophysiology of schizo-
via a common pathway phrenia part 1
of disrupting the function of 1 or more neurotransmit-
ter components.
Dopaminergic theory: Almost all drugs with antipsy-
chotic properties block the dopaminergic D2 receptor.
However, antipsychotics are only 70% effective and
clozapine, the most effective antipsychotic for treating
schizophrenia, is a weak D2 antagonist.
Hyperactivity of dopamine D2 receptor neurotransmis-
sion in subcortical, and limbic brain regions contribute
to the positive symptoms of schizophrenia. Hypo func-
tionality of dopamine D1 receptor neurotransmission
