Ache Practice Exam/Ache Exam Preparation Newest
2025/2026 Complete detailed Questions And 100%
Correct answers Verified for guaranteed pass!!!
Which of the following is the most important determinant of
an allergic drug reaction?
The genetic pedigree of the patient
The oral bioavailability of the drug
The chemical structure of the drug
The liver and kidney functions of the patient
The dose of the drug - ANSWER-Answer: The chemical
structure of the drug
,Some drugs cause allergic reactions very rarely while
other compounds (obviously not used as drugs) can cause
sensitization in all exposed subjects. Therefore the drug
structure is the major determinant of the frequency of an
allergic reaction to a drug.
A) Even if in some rare occurrence the dose can be a
factor predisposing to allergy (i.e penicillin-induced
hemolytic anemia requires high and sustained drug
concentrations) the occurrence and the seriousness of an
allergic reaction is not dose-dependent, in most cases.
C) The bioavailability refer to the fraction of the drug
reaching the general circulation. Since allergy is not
related to dose, bioavailability is not an important factor for
,an allergic drug reaction. Moreover the oral route carried
the lowest risk of allergic reaction.
D) The genetic pedigree is important for idiosyncratic drug
reactions.
E) The patient's liver and kidney functions are important
factors for drug overdose toxicity.
Question 5
pts
Drugs with low-molecular-weight can nevertheless cause
an allergic reaction because they can
Act as antibodies
, Accumulate over time into specific tissues
Alter the genetic makeup of the cells
Act as haptens
Block specific immunologic receptors - ANSWER-Answer:
Act as haptens
Haptens are usually small molecules that are not
immunogenic by themselves. However they can be bound
covalently to a carrier protein and the hapten-carrier
conjugate can induce antibody against the hapten.
A) An allergic reaction is not genetically determined.
2025/2026 Complete detailed Questions And 100%
Correct answers Verified for guaranteed pass!!!
Which of the following is the most important determinant of
an allergic drug reaction?
The genetic pedigree of the patient
The oral bioavailability of the drug
The chemical structure of the drug
The liver and kidney functions of the patient
The dose of the drug - ANSWER-Answer: The chemical
structure of the drug
,Some drugs cause allergic reactions very rarely while
other compounds (obviously not used as drugs) can cause
sensitization in all exposed subjects. Therefore the drug
structure is the major determinant of the frequency of an
allergic reaction to a drug.
A) Even if in some rare occurrence the dose can be a
factor predisposing to allergy (i.e penicillin-induced
hemolytic anemia requires high and sustained drug
concentrations) the occurrence and the seriousness of an
allergic reaction is not dose-dependent, in most cases.
C) The bioavailability refer to the fraction of the drug
reaching the general circulation. Since allergy is not
related to dose, bioavailability is not an important factor for
,an allergic drug reaction. Moreover the oral route carried
the lowest risk of allergic reaction.
D) The genetic pedigree is important for idiosyncratic drug
reactions.
E) The patient's liver and kidney functions are important
factors for drug overdose toxicity.
Question 5
pts
Drugs with low-molecular-weight can nevertheless cause
an allergic reaction because they can
Act as antibodies
, Accumulate over time into specific tissues
Alter the genetic makeup of the cells
Act as haptens
Block specific immunologic receptors - ANSWER-Answer:
Act as haptens
Haptens are usually small molecules that are not
immunogenic by themselves. However they can be bound
covalently to a carrier protein and the hapten-carrier
conjugate can induce antibody against the hapten.
A) An allergic reaction is not genetically determined.
