NR 546 Week 4 Anxiolytic Table – Advanced Pharmacology Study Notes (2026/2027)

Chamberlain University

NR 546 / NR546
Week 4
Anxiolytic Table

Course: Advanced Pharmacology

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Anxiolytic Medications
Drug Name/ Indication Associated Half-life (T1/2) Notable side effects
Medication list diagnosis and targeted Neurotransmitters Metabolism (CYP 450
class symptoms enzyme)

Gabapentin  Partial seizures  Binds to the alpha Half-Life  Sedation, dizziness
 Postherpetic neuralgia 2 delta subunit of  5-7 hrs.  Ataxia, fatigue, nystagmus, tremor
 Restless leg syndrome voltage-sensitive Metabolism  Peripheral edema
 Neuropathic pain/ calcium channels  Does not metabolize  Blurred vision
chronic pain but excreted intact  Vomiting, dyspepsia, diarrhea, dry mouth,
 Anxiety renally constipation, weight gain
 Bipolar disorder  Additional effects in children under 12:
hostility, emotional lability, hyperkinesia,
thought disorder, weight gain
Pregabalin  Diabetic peripheral  Binds to the alpha Half-Life  Sedation, dizziness
neuropathy 2 delta subunit of  5-7 hours  Ataxia, fatigue, tremor, dysarthria,
 Postherpetic neuralgia voltage-sensitive Metabolism paresthesia, memory impairment,
 Fibromyalgia calcium channels  Pregabalin is not coordination abnormal, impaired
 Neuropathic pain metabolized but attention, confusion, euphoric mood,
associated with spinal excreted intact irritability
cord injury renally  Vomiting, dry mouth, constipation,
 Partial onset seizures weight gain, increased appetite,
in adults and pediatric flatulence
patients  Blurred vision, diplopia
 Peripheral  Peripheral Edema
neuropathic pain  Libido decreased, erectile dysfunction
 GAD
 Panic disorder
 Social anxiety disorder
Buspirone  Major depressive  Boost Half life  Dry mouth, constipation, nausea, weight
disorder neurotransmitter  Parent: 10-14 Hrs. loss, anorexia, myalgia
 Seasonal affective norepinephrine/n  Metabolite: 20-  Insomnia, dizziness, headache, agitation,
disorder oradrenaline and 27Hrs. anxiety, tremor, abdominal pain, tinnitus
 Nicotine addiction dopamine Metabolism  Sweating
 Bipolar depression  CYP450 2D6  Rash
 Attention deficit  Blocks  Hypertension
hyperactivity disorder norepinephrine
(ADHD) reuptake pump,
 Sexual Dysfunction presumably
increasing