ATI RN EXAM 2 PRACTICE EXAM QUESTIONS AND
CORRECT ANSWERS HIGHLIGHTED NEW MODIFIED
EXAM TESTED AND APPROVED WITH RATIONALES
2025/2026 LATEST
1. A nurse is caring for a client who is taking lisinopril. Which of the following outcomes
indicates a therapeutic effect of the medication?
A. Decreased blood pressure
Rationale: Lisinopril, an ACE inhibitor, may be used alone or in combination with
other antihypertensives in the management of hypertension and congestive
heart failure. A therapeutic effect of the medication is a decrease in blood
pressure.
B. Increase of HDL cholesterol
Rationale: This is not an intended effect of lisinopril.
C. Prevention of bipolar manic episodes
Rationale: This is not an intended effect of lisinopril.
D. Improved sexual function
Rationale: This is not an intended effect of lisinopril. Lisinopril may in fact cause
sexual dysfunction and impotence.
Page 1 of 110
,2. A nurse is caring for a client who has a new prescription for ferrous sulfate tablets twice
daily for iron-deficiency anemia. The client asks the nurse why the provider instructed
that she take the ferrous sulfate between meals. Which of the following responses should
the nurse make?
A. "Taking the medication between meals will help you avoid becoming constipated."
Rationale: Taking the medication with food can reduce the GI symptoms associated
with it. However, taking the medication between meals maximizes
absorption.
B. "Taking the medication with food increases the risk of esophagitis."
Rationale: Reclining immediately after taking ferrous sulfate may lead to
esophageal corrosion. Clients should remain upright for 15-30 min
following administering.
C. "Taking the medication between meals will help you absorb the medication more
efficiently."
Rationale: Ferrous sulfate provides the iron needed by the body to produce red
blood cells. Taking iron supplements between meals helps to increase the
bioavailability of the iron.
D. "The medication can cause nausea if taken with food."
, Rationale: Taking ferrous sulfate with food can reduce the GI symptoms associated
with it. However, taking the medication between meals maximizes
absorption.
3. A nurse is caring for a client who has chronic renal disease and is receiving therapy with
epoetin alfa. Which of the following laboratory results should the nurse review for an
indication of a therapeutic effect of the medication?
A. The leukocyte count
Rationale: Epoetin alfa does not affect the leukocyte, or WBC, count.
B. The platelet count
Rationale: An increase in platelets is not the therapeutic or desired effect of epoetin
alfa.
C. The hematocrit (Hct)
Rationale: Epoetin alfa is an antianemic medication that is indicated in the
treatment of clients who have anemia due to reduced production of
endogenous erythropoietin, which may occur in clients who have end-stage
renal disease or myelosuppression from chemotherapy. The therapeutic
effect of epoetin alfa is enhanced red blood cell production, which is
reflected in an increased RBC, Hgb, and Hct.
D. The erythrocyte sedimentation rate
(ESR) Rationale:
Page 3 of 110
, Epoetin alfa does not affect the ESR, which is a measurement of
inflammation.
4. A nurse is preparing to initiate a transfusion of packed RBC for a client who has anemia.
Which of the following actions should the plan to nurse take?
A. Leave the client 5 min after beginning the transfusion.
Rationale: The nurse should remain with the client for 15 to 30 min after the
start of the transfusion to monitor for a reaction, which usually occurs during the first
50 mL of the transfusion. B. Infuse the transfusion at a rate of 200 mL/hr.
Rationale: The transfusion should infuse in 2 to 4 hr to prevent fluid overload.
C. Check the client's vital signs every hour during the transfusion.
Rationale: The nurse should check the client's vital signs every 15 min at the start
of the transfusion, then every 1 hr to monitor for a transfusion reaction. D. Flush the
blood tubing with dextrose 5% in water.
Rationale: The nurse should flush the blood tubing with 0.9% sodium chloride to
prevent hemolysis of the blood.
CORRECT ANSWERS HIGHLIGHTED NEW MODIFIED
EXAM TESTED AND APPROVED WITH RATIONALES
2025/2026 LATEST
1. A nurse is caring for a client who is taking lisinopril. Which of the following outcomes
indicates a therapeutic effect of the medication?
A. Decreased blood pressure
Rationale: Lisinopril, an ACE inhibitor, may be used alone or in combination with
other antihypertensives in the management of hypertension and congestive
heart failure. A therapeutic effect of the medication is a decrease in blood
pressure.
B. Increase of HDL cholesterol
Rationale: This is not an intended effect of lisinopril.
C. Prevention of bipolar manic episodes
Rationale: This is not an intended effect of lisinopril.
D. Improved sexual function
Rationale: This is not an intended effect of lisinopril. Lisinopril may in fact cause
sexual dysfunction and impotence.
Page 1 of 110
,2. A nurse is caring for a client who has a new prescription for ferrous sulfate tablets twice
daily for iron-deficiency anemia. The client asks the nurse why the provider instructed
that she take the ferrous sulfate between meals. Which of the following responses should
the nurse make?
A. "Taking the medication between meals will help you avoid becoming constipated."
Rationale: Taking the medication with food can reduce the GI symptoms associated
with it. However, taking the medication between meals maximizes
absorption.
B. "Taking the medication with food increases the risk of esophagitis."
Rationale: Reclining immediately after taking ferrous sulfate may lead to
esophageal corrosion. Clients should remain upright for 15-30 min
following administering.
C. "Taking the medication between meals will help you absorb the medication more
efficiently."
Rationale: Ferrous sulfate provides the iron needed by the body to produce red
blood cells. Taking iron supplements between meals helps to increase the
bioavailability of the iron.
D. "The medication can cause nausea if taken with food."
, Rationale: Taking ferrous sulfate with food can reduce the GI symptoms associated
with it. However, taking the medication between meals maximizes
absorption.
3. A nurse is caring for a client who has chronic renal disease and is receiving therapy with
epoetin alfa. Which of the following laboratory results should the nurse review for an
indication of a therapeutic effect of the medication?
A. The leukocyte count
Rationale: Epoetin alfa does not affect the leukocyte, or WBC, count.
B. The platelet count
Rationale: An increase in platelets is not the therapeutic or desired effect of epoetin
alfa.
C. The hematocrit (Hct)
Rationale: Epoetin alfa is an antianemic medication that is indicated in the
treatment of clients who have anemia due to reduced production of
endogenous erythropoietin, which may occur in clients who have end-stage
renal disease or myelosuppression from chemotherapy. The therapeutic
effect of epoetin alfa is enhanced red blood cell production, which is
reflected in an increased RBC, Hgb, and Hct.
D. The erythrocyte sedimentation rate
(ESR) Rationale:
Page 3 of 110
, Epoetin alfa does not affect the ESR, which is a measurement of
inflammation.
4. A nurse is preparing to initiate a transfusion of packed RBC for a client who has anemia.
Which of the following actions should the plan to nurse take?
A. Leave the client 5 min after beginning the transfusion.
Rationale: The nurse should remain with the client for 15 to 30 min after the
start of the transfusion to monitor for a reaction, which usually occurs during the first
50 mL of the transfusion. B. Infuse the transfusion at a rate of 200 mL/hr.
Rationale: The transfusion should infuse in 2 to 4 hr to prevent fluid overload.
C. Check the client's vital signs every hour during the transfusion.
Rationale: The nurse should check the client's vital signs every 15 min at the start
of the transfusion, then every 1 hr to monitor for a transfusion reaction. D. Flush the
blood tubing with dextrose 5% in water.
Rationale: The nurse should flush the blood tubing with 0.9% sodium chloride to
prevent hemolysis of the blood.
