Exam 4 (RUSH NSG 531
Advanced Pharm)
Comprehensive Questions with
Verified Answers Graded A+
G1 Phase - Answer: cellular content (not DNA) is duplicated
S Phase - Answer: DNA duplication and synthesis of new DNA
DNA is synthesized via what enzyme? - Answer: DNA polymerase
G2 Phase - Answer: Another growth and check phase where any final repairs are made before
Mitosis
M Phase - Answer: mitosis and formation of microtubules with the goal of forming 2 daughter
cells
What protein suppresses tumors? - Answer: p53
Cell cycle nonspecific drugs include - Answer: DNA Alkylating
DNA Intercalating
, Bleomycin - Answer: cell cycle specific on G2 phase
Etoposide - Answer: cell cycle specific on G2 phase
MOA for Antimetabolites - Answer: inhibit DNA synthesis enzymes
MOA for Alkylating Agents - Answer: Alkyl group gets added to DNA, causing damage
MOA for Platinum Analogs - Answer: form links between Guanines, damaging the DNA so
polymerase cant read it
MOA for Microtubule Inhibitors - Answer: inhibit the formation of microtubule polymerization
Methotrexate - Answer: antimetabolite
inhibits dihydrofolate reductase
5-Flurocil - Answer: antimetabolite
inhibits thymidylate synthase
Cytarabine - Answer: Antimetabolite
Cyclophosphamide - Answer: Alkylating agent via Liver and p450 system
Nitrosurea - Answer: Alkylating agent that is lipid soluble and used for brain tumors
Cisplatin - Answer: Platinum analog
Advanced Pharm)
Comprehensive Questions with
Verified Answers Graded A+
G1 Phase - Answer: cellular content (not DNA) is duplicated
S Phase - Answer: DNA duplication and synthesis of new DNA
DNA is synthesized via what enzyme? - Answer: DNA polymerase
G2 Phase - Answer: Another growth and check phase where any final repairs are made before
Mitosis
M Phase - Answer: mitosis and formation of microtubules with the goal of forming 2 daughter
cells
What protein suppresses tumors? - Answer: p53
Cell cycle nonspecific drugs include - Answer: DNA Alkylating
DNA Intercalating
, Bleomycin - Answer: cell cycle specific on G2 phase
Etoposide - Answer: cell cycle specific on G2 phase
MOA for Antimetabolites - Answer: inhibit DNA synthesis enzymes
MOA for Alkylating Agents - Answer: Alkyl group gets added to DNA, causing damage
MOA for Platinum Analogs - Answer: form links between Guanines, damaging the DNA so
polymerase cant read it
MOA for Microtubule Inhibitors - Answer: inhibit the formation of microtubule polymerization
Methotrexate - Answer: antimetabolite
inhibits dihydrofolate reductase
5-Flurocil - Answer: antimetabolite
inhibits thymidylate synthase
Cytarabine - Answer: Antimetabolite
Cyclophosphamide - Answer: Alkylating agent via Liver and p450 system
Nitrosurea - Answer: Alkylating agent that is lipid soluble and used for brain tumors
Cisplatin - Answer: Platinum analog
