VERIFIED Pharmacology Test3 Exam With 201Questions and Answers all Answers 100%Correctly/Verified Answers Brand New 2024/2025 RATED A+

Pharmacology Test3 Exam With 201Questions and Answers
all Answers 100%Correctly/Verified Answers Brand New
2024/2025 RATED A+
What is the patho of Parkinsonism? - CORRECT ANSWERS imbalance between excitatory
cholinergic neurons and greatly diminished numbers of inhibitory dopaminergic neurons



What is the pharmacological goal for Parkinson's disease? - CORRECT ANSWERS to restore
dopamine in the basal ganglia and antagonizing

the excitatory effect of acetylcholine at the muscarinic receptors



Which of these symptoms are improved with Anticholinergic (antimuscarinic) Agents in
Parkinson's?

- Tremor

- Bradykinesia

- Rigidity - CORRECT ANSWERS Tremor and Rigidity



How do anticholinergics work? - CORRECT ANSWERS Block ACh from binding to receptor sites.



What disease can Cogentin (benztropine) precipitate - CORRECT ANSWERS Narrow-angle
glaucoma



What are the cautions for Benztropine (cogentin) - CORRECT ANSWERS in elderly, BPH, urinary
retention, liver, renal or

GI or GU disease



What kind of a drug is Pramipexole (Mirapex)? - CORRECT ANSWERS Dopamine Receptor Agonist



What can Pramipexole (Mirapex) be used for? - CORRECT ANSWERS - Mild Parkinsonism used in
combo with Levadopa

- Restless leg syndrome




Pharmacology Test3 Exam With 201Questions and Answers all Answers
100%Correctly/Verified Answers Brand New 2024/2025 RATED A+

,Pharmacology Test3 Exam With 201Questions and Answers
all Answers 100%Correctly/Verified Answers Brand New
2024/2025 RATED A+
What is the main caution for Pramipexole (Mirapex) - CORRECT ANSWERS Renal Function, caution
with other drugs with renal implications



Common ADE with Pramipexole (mirapex) - CORRECT ANSWERS CNS issues: confusion,
delusion, hallucinations, impulsivity



N/V, Anorexia



What drugs do you not combined with MOA-B inhibitors (Selegiline & Azilect/ Rasagiline) -
CORRECT ANSWERS Fluoxetine or Meperidine



What is the MOA of Levadopa/Carbidopa - CORRECT ANSWERS Enhances synthesis of dopamine
in surviving neurons of the substantia nigra



Conversion of levodopa to dopamine



Does the effect of Levadopa/Carbidopa last after the drug has left the body - CORRECT ANSWERS
No the effect ends as soon as the drug is out of the system



How long does Levadopa/Carbidopa last for a patient - CORRECT ANSWERS 3-5 years, then see
decline in response to drug



MOA of Levadopa - CORRECT ANSWERS Attempts to replace dopamine that is deficient



crosses the BBB to convert to dopamine in the braine



MOA of Carbidopa - CORRECT ANSWERS Enhances effect of levadopa by DIMINISHING the
uptake of levadopa in the GI tract and peripheral tissues



Pharmacology Test3 Exam With 201Questions and Answers all Answers
100%Correctly/Verified Answers Brand New 2024/2025 RATED A+

, Pharmacology Test3 Exam With 201Questions and Answers
all Answers 100%Correctly/Verified Answers Brand New
2024/2025 RATED A+
Means more of the drug gets to the CNS



What symptoms does Levodopa decrease - CORRECT ANSWERS Decreases rigidity, tremors, &
other symptoms



Should levodopa be taken with meals or on an empty stomach - CORRECT ANSWERS Empty
stomach; Meals interfere with transport into the CNS



What are the GI ADE with levodopa - CORRECT ANSWERS Anorexia, N/V

D/T stimulation of chemoreceptor trigger zone of the medulla



What are the CV ADE of Levodopa - CORRECT ANSWERS Tachycardia, PVCs, postural hypotension

D/t dopaminergic action on the heart



What psych dx do you NOT give levodopa to - CORRECT ANSWERS Psychosis



What are the ADE CNS effects of levodopa - CORRECT ANSWERS Visual/Auditory hallucinations,
abnormal involuntary

movements -dyskinesias (effects opposite of Parkinson's symptoms )



What is the first line treatment for parkinsons - CORRECT ANSWERS Dopamine Agonists
(Carbidopa/Levodopa)



What do COMT inhibitors do? - CORRECT ANSWERS reduces motor fluctuations in advanced dx-
but

increase dyskinesias (adjunctive tx)



What are the results of using Anticholinergics in Parkinson's? - CORRECT ANSWERS reduce
tremor, rigidity and drooling (limited use d/t ADE)

Pharmacology Test3 Exam With 201Questions and Answers all Answers
100%Correctly/Verified Answers Brand New 2024/2025 RATED A+