USP 800 and hazardous drug
handling hazardous drugs in healthcare settings for
USP 800
safety and environmental protection
what are hazardous drugs? carcinogenic, teratogenic, reproductive toxicity, organ
toxicity, geotaxis,
NIOSH list National institute for occupational safety and health
Full name: NIOSH list of
antineoplastic and other
hazardous drugs in
healthcare
settings
1. antineoplastic drugs
NIOSH drugs divided into 3 2. non antineoplastic drugs
groups 3. drugs that pose reproductive risk
estrogens, clonazepam, phenytoin, raloxifine,
common drugs on NIOSH list topiramate, dutasteride, voriconzaole, risperidone,
carbamazepine, fluconazole, colchicine, paroxetine,
valproic acid, spironolactone
most pharmacies stock at least one of the
medications on the NIOSH list
Nosh is not continuously updated; facility
needs to review hazards of new drugs
1. check SDSs (safety date sheets) from manufacturer
to evaluate hazardous
, potential 2. review product labeling
1. dermal/mucosal absorption
routes of unintentional entry 2. inhalation
of hazardous drugs into 3. injection
body include
4. ingestion
receipt contact has drugs residues on container, work surface, floors
dispensing contact with HD when counting or repacking tablets or
capsules
compounding/manipulation manipulating drugs, coming into contact with HD
administration IV set, specialized procedures, aerosols
patient care activities handling body fluids or body fluid contaminated materials
spills spills, management and disposal
transport moving HD in a healthcare setting
waste collection and disposal of HD waste
each facility needs to identify HD meds to
ensure procedures for safe handling
dispensing a single low risk, just use gloves
unopened intact tablet or
capsule
repeatedly counting, higher risk, need double gloves, protective gown,
cutting or crushing tablets respiratory protection and disposable pad
compounding IV products very high risk, double gloves, protective gown, and
of hazardous drugs primary engineering control (BSC or CACI)
drugs on NIOSH list that - HD active pharmaceutical ingredient (powder/substances in
must follow USP 800 compounding)
-antineoplastic that needs manipulating
handling hazardous drugs in healthcare settings for
USP 800
safety and environmental protection
what are hazardous drugs? carcinogenic, teratogenic, reproductive toxicity, organ
toxicity, geotaxis,
NIOSH list National institute for occupational safety and health
Full name: NIOSH list of
antineoplastic and other
hazardous drugs in
healthcare
settings
1. antineoplastic drugs
NIOSH drugs divided into 3 2. non antineoplastic drugs
groups 3. drugs that pose reproductive risk
estrogens, clonazepam, phenytoin, raloxifine,
common drugs on NIOSH list topiramate, dutasteride, voriconzaole, risperidone,
carbamazepine, fluconazole, colchicine, paroxetine,
valproic acid, spironolactone
most pharmacies stock at least one of the
medications on the NIOSH list
Nosh is not continuously updated; facility
needs to review hazards of new drugs
1. check SDSs (safety date sheets) from manufacturer
to evaluate hazardous
, potential 2. review product labeling
1. dermal/mucosal absorption
routes of unintentional entry 2. inhalation
of hazardous drugs into 3. injection
body include
4. ingestion
receipt contact has drugs residues on container, work surface, floors
dispensing contact with HD when counting or repacking tablets or
capsules
compounding/manipulation manipulating drugs, coming into contact with HD
administration IV set, specialized procedures, aerosols
patient care activities handling body fluids or body fluid contaminated materials
spills spills, management and disposal
transport moving HD in a healthcare setting
waste collection and disposal of HD waste
each facility needs to identify HD meds to
ensure procedures for safe handling
dispensing a single low risk, just use gloves
unopened intact tablet or
capsule
repeatedly counting, higher risk, need double gloves, protective gown,
cutting or crushing tablets respiratory protection and disposable pad
compounding IV products very high risk, double gloves, protective gown, and
of hazardous drugs primary engineering control (BSC or CACI)
drugs on NIOSH list that - HD active pharmaceutical ingredient (powder/substances in
must follow USP 800 compounding)
-antineoplastic that needs manipulating
