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1. Mycology - ANSWER the study of fungi
2. Fungi characteritics - ANSWER -aerobic: NO fermentation
-grow at 22-30 C (~ room temp)
-grow at neutral pH
-prefer humid conditions
-eukaryotic cells
-many are free living in the environment (saprobes) and do not cause disease
3. Eukaryotes - ANSWER fungal cells
-cell wall of chitin
-80 S ribosomes
-membrane bound organelles
-ergoserol cellular membranes
-contains nucleus (often multinucleate) and nuclear membrane
,-contains DNA organized into chromosomes within the nucleus
-replicates by mitosis or budding
-nonmotile
4. Prokaryotes - ANSWER bacteria
-cell walls made of peptidoglycan
-70S ribosome
-non-bound organelles
-cellular membrane not made of sterols
-no nucleus
-genetic material organised into a single nucleoid
-replicate by binary fission
-some are motile
5. Fungi names - ANSWER anything containing "myco" or "mycetes" indiciates
fungi
6. Mycoses - ANSWER fungal infections
-only a small number of fungi are able to cause infections in humans
-very few of the infections caused by fungi are able to be transmitted from person
to person (usually environmental)
-infections are seen most often in immunocomprimsed patients (oppurtunistic
infections)
,7. Types of fungal disease - ANSWER -mycotoxicosis
-hypersensitivity: mold allergy
-colonization
-infection: can be mild to life threatening
8. Mycoses classifications - ANSWER fungal infections are classified according
to the site of the infection on the body
-superficial
-cutaneous
-subcutaneous
-systemic
-oppurtunistic
9. Superficial fungal infections - ANSWER infection of the hair, skin and nails
-infection is not invasive or destructive
-not really painful, just cause appearance issues (hyperpigmentation,
hypopigmentation)
10. Cutaneous fungal infections - ANSWER infections of the hair, skin and nails
-some kind of destruction is occurring, but not life-threatening
-e.g. hair falls out, itching, nails become thick and yellowed
11. Subcutaneous fungal infections - ANSWER infection of deeper skin layers,
muscle, connective tissue, and bone
, -usually occurs by traumatic inoculation of fungus into deeper tissues
-causes formation of progressive non-healing ulcers with draining sinus tracts
-e.g. sporotrichosis
12. Systemic fungal infections - ANSWER infections of the internal organs, or
deep tissues
-usually occurs by inhalation through the lungs followed by hematogenous spread
-caused by TRUE fungal pathogens
-generalized symptoms: fever, fatigue
-potentially life-threatening infections
-e.g. coccidiodomycosis
13. Opportunistic fungal infections - ANSWER invasive infections in
immunocompromised patients (e.g. AIDS, transplant pt, cancer pt)
-can vary from cutaneous to systemic (what the actual infection is can vary a lot,
the only thing that is constant is that the host is immunocompromised)
-e.g. candidiasis
14. Fungal cell wall - ANSWER contains chitin, mannan and ß-glucan
(components only found in fungi)
-determines shape
-attaches to host cell
-causes inflammation in host