QUESTIONS AND CORRECT ANSWERS
Pathophysiology of BPH? - Correct answers✔✔-Testosterone is important for maintaining good
prostate function
-Testosterone diminishes as men age, contributing to prostatic hyperplasia
-
Testosterone → 5a-reductase → DHT
DHT plays a role in development of BPH, so we want to block 5a-reductase*
BPH static and dynamic component explained - Correct answers✔✔Static = hyperplasticity
(increase in number) of cells in prostate → prostate increases in size → constriction of urethra →
bladder obstruction
Over time, hyperplasticity of cells causes stress on bladder, loses normal ability to void and fill
(this causes irritative symptoms)*
Dynamic = stimulation of alpha receptors (vasoconstriction around urethra) — we want to block
alpha receptors → relaxation of urethra, easier to urinate
BPH can cause _______ in men, causing men to seek treatment - Correct answers✔✔LUTS
(lower urinary tract syndrome)
Symptoms of voiding (obstructive) - Correct answers✔✔Hesitancy, straining, weak flow,
terminal dribbling, overflow incontinence, retention
, Symptoms of storage (irritative) - Correct answers✔✔Frequency, urgency, nocturia, urge
incontinence
-What score indicates "mild" on the Quantitative Symptom Assessment?
- What score indicates "moderate" on the Quantitative Symptom Assessment?
- What score indicates "severe" on the Quantitative Symptom Assessment? - Correct
answers✔✔- 0-7
- 8-19
- >20
What medications cause BPH/LUTS in men? - Correct answers✔✔- Antihistamines,
phenothiazines, anticholinergic agents, testosterone, alpha-adrenergic receptor agonists
(pseudophedrine), diuretics
What kind of patients get watchful waiting? - Correct answers✔✔- Pts with mild LUTS
(AUA<8)
- Pts with moderate or severe symptoms who are not bothered by LUTS
Lifestyle modifications for BPH/LUTS? - Correct answers✔✔- Encourage pts to maintain a
healthy lifestyle
-Reduce caffeine
- Avoid excessive fluid intake
Void before bed and long car rides