NURSE 660 EXAM 4 REVIEW QUESTIONS AND
COMPLETE DETAILED CORRECT ANSWERS
Atomoxine (Straterra) - answer ✔✔-Which medication is contraindicated with liver impairment?
Ebstein's anomaly - answer ✔✔-What is one of the birth defects associated with Litihum?
Paroxetine (Paxil) - answer ✔✔-Which SSRI drug causes cardiovascular malformations in the first
trimester of pregnancy?
increases the intrasynaptic levels of both dopamine and norepinephrine - answer ✔✔-Mechanism of
action of a stimulant for ADHD Methylphenidate and amphetamine?
Nicotine alpha 4 beta 2 post synaptic receptors desensitizes receptors which leads to addiction. Re-
sensitization of the nicotine receptors leads to withdrawal - answer ✔✔-What causes nicotine
withdrawal symptoms?
Dorsal lateral prefontal cortex (CTSC loop) - answer ✔✔-A patient diagnosed with ADHD can't stay
focused or solve work-related problems difficulty maintaining attention sustained and problem-solving.
What area of the brain is involved?
Dorsal anterior singlunate - answer ✔✔-What part of the brain is associated with selective attention?
Prefrontal motor cortex - answer ✔✔-What part of the brain is associated with hyperactivity?
Orbitofrontal cortex - answer ✔✔-What part of the brain is associated with impulsivity?
increases dopamine in the dorsal prefrontal cortex and not in the nucleus accumbens - answer ✔✔-
Atomoxetine (Strattera) lacks abuse potential because of what
, Spina bifida - answer ✔✔-What fetal malformation does valproate cause?
ventral striatum - answer ✔✔-What region of the brain is hypothesized to cause impulsivity?
Dorsal striatum - answer ✔✔-What region of the brain controls compulsivity?
Selective Norepinephrine Reuptake Inhibitor: Boosts neurotransmitter norepinephrine/ noradrenaline
and may also increase dopamine in profrontal cortex • Blocks norepinephrine reuptake pumps, also
known as norepinephrine transporters • - answer ✔✔-What is the MOA of atomoxetine (Strattera)?
Alpha-secretase - answer ✔✔-Amaloid precursor protein is first cleaved by what enzyme
increases the effect of the drug in the body - answer ✔✔-What does paroxetine do to Straterra in the
body?
The dose should be decreased - answer ✔✔-If a patient is taking paroxetine and starts Straterra what
should change about the Straterra dose?
GI side effects; inhibits peripheral uptake of ACH and butyrycholine - answer ✔✔-An Alzheimer's patient
has been taking 4mg of rivastigmine what side effects might you anticipate and why?
Pulsatile delivery of stimulants can cause a frequent and rapid delivery amplifying phasic firing of NE and
DA. Phasic firing is associated with reward, euphoria, and abuse - answer ✔✔-Which neurotransmitters
lead to eurphoria and abuse in a patient with marijuana abuse and ADHD.
lowers the rate of drug metabolism - answer ✔✔-What does alcohol do to the CYP 450 system?
Guanfacine, both are alpha 2a agonists - answer ✔✔-Which ADHD medication is tolerated better
guanfacine or clonidine?
they have the same key binding site for the serotonin 2a receptor - answer ✔✔-Why do some people
with ADHD abuse cocaine? What MOA does cocaine affect the same as methylphenidate?
COMPLETE DETAILED CORRECT ANSWERS
Atomoxine (Straterra) - answer ✔✔-Which medication is contraindicated with liver impairment?
Ebstein's anomaly - answer ✔✔-What is one of the birth defects associated with Litihum?
Paroxetine (Paxil) - answer ✔✔-Which SSRI drug causes cardiovascular malformations in the first
trimester of pregnancy?
increases the intrasynaptic levels of both dopamine and norepinephrine - answer ✔✔-Mechanism of
action of a stimulant for ADHD Methylphenidate and amphetamine?
Nicotine alpha 4 beta 2 post synaptic receptors desensitizes receptors which leads to addiction. Re-
sensitization of the nicotine receptors leads to withdrawal - answer ✔✔-What causes nicotine
withdrawal symptoms?
Dorsal lateral prefontal cortex (CTSC loop) - answer ✔✔-A patient diagnosed with ADHD can't stay
focused or solve work-related problems difficulty maintaining attention sustained and problem-solving.
What area of the brain is involved?
Dorsal anterior singlunate - answer ✔✔-What part of the brain is associated with selective attention?
Prefrontal motor cortex - answer ✔✔-What part of the brain is associated with hyperactivity?
Orbitofrontal cortex - answer ✔✔-What part of the brain is associated with impulsivity?
increases dopamine in the dorsal prefrontal cortex and not in the nucleus accumbens - answer ✔✔-
Atomoxetine (Strattera) lacks abuse potential because of what
, Spina bifida - answer ✔✔-What fetal malformation does valproate cause?
ventral striatum - answer ✔✔-What region of the brain is hypothesized to cause impulsivity?
Dorsal striatum - answer ✔✔-What region of the brain controls compulsivity?
Selective Norepinephrine Reuptake Inhibitor: Boosts neurotransmitter norepinephrine/ noradrenaline
and may also increase dopamine in profrontal cortex • Blocks norepinephrine reuptake pumps, also
known as norepinephrine transporters • - answer ✔✔-What is the MOA of atomoxetine (Strattera)?
Alpha-secretase - answer ✔✔-Amaloid precursor protein is first cleaved by what enzyme
increases the effect of the drug in the body - answer ✔✔-What does paroxetine do to Straterra in the
body?
The dose should be decreased - answer ✔✔-If a patient is taking paroxetine and starts Straterra what
should change about the Straterra dose?
GI side effects; inhibits peripheral uptake of ACH and butyrycholine - answer ✔✔-An Alzheimer's patient
has been taking 4mg of rivastigmine what side effects might you anticipate and why?
Pulsatile delivery of stimulants can cause a frequent and rapid delivery amplifying phasic firing of NE and
DA. Phasic firing is associated with reward, euphoria, and abuse - answer ✔✔-Which neurotransmitters
lead to eurphoria and abuse in a patient with marijuana abuse and ADHD.
lowers the rate of drug metabolism - answer ✔✔-What does alcohol do to the CYP 450 system?
Guanfacine, both are alpha 2a agonists - answer ✔✔-Which ADHD medication is tolerated better
guanfacine or clonidine?
they have the same key binding site for the serotonin 2a receptor - answer ✔✔-Why do some people
with ADHD abuse cocaine? What MOA does cocaine affect the same as methylphenidate?
