CML QUESTIONS AND SOLUTIONS 2025/2026 ALL GRADED
A+
✔✔what is significant about the sclera anicteric - ✔✔liver and pancreas are not that bad
and haven't been affected because byproduct of cell destruction is bilirubin and causes
jaundice
✔✔conjugated estrogens treat? - ✔✔hot flashes
✔✔alendronate sodium treats - ✔✔osteoporosis
✔✔feofenadine treats - ✔✔hay fever
✔✔what pre existing health conditions can promote onset of CML - ✔✔Hepatitis
gout
osteoporosis
✔✔what is priapism - ✔✔persistent and painful erection of the penis
✔✔why are patients with CML hyperuricemic - ✔✔because when cells breakdown they
produce uric acid as a byproduct
✔✔Why are infiltrates of leukemic white blood cells found in the skin, lymph nodes, and
central nervous system of patients with chronic myeloge- nous leukemia? - ✔✔It is
myeloproliferative
✔✔Distinguish the pathophysiology of splenomegaly in patients with chronic
myelogenous leukemia from those patients with right heart failure and portal
hypertension due to cirrhosis. - ✔✔In CML the spleen is enlarged because its over
working to filter out bad cells and try and fix the CML
In heart failure the spleen is more of the result of the backup
✔✔why is their pallor - ✔✔decreased RBC an Hg
✔✔what is nose bleed from? - ✔✔thrombocytopenia
✔✔Which medications are used for CML in older patients - ✔✔Gleevec, Tasigna or
Sprycel
✔✔______ is a slowly progressive (i.e., chronic) type of cancer of the blood and bone
marrow in which the bone marrow produces too many WBCs of the myeloid stem cell
line known as granulocytes. - ✔✔CML
, ✔✔CML is also considered one of a number of______________disorder -
✔✔myeloproliferative
✔✔CML is a cancer of the white blood cells specifically affection _______ that presents
in slowly progressing form - ✔✔myeloblasts
✔✔The classic triad of this is: - ✔✔night sweats, fever, tired
✔✔who is incidence higher in? - ✔✔middle aged adults
✔✔fatigue
weakness
loss of appetite
unintentional weight loss excessive sweating
bleeding
bruising
left upper quadrant pain - ✔✔CML symptoms
✔✔what is the only known treatment ? - ✔✔bone marrow transplant
✔✔What are the risk factors of CML - ✔✔radiation
benzene exposure
✔✔The basic mechanism of _____________________ involves genetic injury to cells
that disrupts growth control and differentiation pathways. - ✔✔malignant transformation
✔✔In CML what are being injured and therefore cannot mature - ✔✔granulocysts
✔✔What are granulocytes - ✔✔blast cells in the myeloid cell lineage developing in WBC
✔✔As the disease progresses, _______________accumulate in large numbers within
the bone marrow and blood and eventually crowd out healthy components of the blood -
✔✔granulocytes
✔✔because it is a myeloproliferative disorder what is this patient at risk of? - ✔✔anemia
infection
bleeding
brusing
✔✔The precise DNA mutation that causes CML is ? - ✔✔Philedelphia chromosome
✔✔what is a phildelphia chromosome - ✔✔abnormally short chromosome 22
A+
✔✔what is significant about the sclera anicteric - ✔✔liver and pancreas are not that bad
and haven't been affected because byproduct of cell destruction is bilirubin and causes
jaundice
✔✔conjugated estrogens treat? - ✔✔hot flashes
✔✔alendronate sodium treats - ✔✔osteoporosis
✔✔feofenadine treats - ✔✔hay fever
✔✔what pre existing health conditions can promote onset of CML - ✔✔Hepatitis
gout
osteoporosis
✔✔what is priapism - ✔✔persistent and painful erection of the penis
✔✔why are patients with CML hyperuricemic - ✔✔because when cells breakdown they
produce uric acid as a byproduct
✔✔Why are infiltrates of leukemic white blood cells found in the skin, lymph nodes, and
central nervous system of patients with chronic myeloge- nous leukemia? - ✔✔It is
myeloproliferative
✔✔Distinguish the pathophysiology of splenomegaly in patients with chronic
myelogenous leukemia from those patients with right heart failure and portal
hypertension due to cirrhosis. - ✔✔In CML the spleen is enlarged because its over
working to filter out bad cells and try and fix the CML
In heart failure the spleen is more of the result of the backup
✔✔why is their pallor - ✔✔decreased RBC an Hg
✔✔what is nose bleed from? - ✔✔thrombocytopenia
✔✔Which medications are used for CML in older patients - ✔✔Gleevec, Tasigna or
Sprycel
✔✔______ is a slowly progressive (i.e., chronic) type of cancer of the blood and bone
marrow in which the bone marrow produces too many WBCs of the myeloid stem cell
line known as granulocytes. - ✔✔CML
, ✔✔CML is also considered one of a number of______________disorder -
✔✔myeloproliferative
✔✔CML is a cancer of the white blood cells specifically affection _______ that presents
in slowly progressing form - ✔✔myeloblasts
✔✔The classic triad of this is: - ✔✔night sweats, fever, tired
✔✔who is incidence higher in? - ✔✔middle aged adults
✔✔fatigue
weakness
loss of appetite
unintentional weight loss excessive sweating
bleeding
bruising
left upper quadrant pain - ✔✔CML symptoms
✔✔what is the only known treatment ? - ✔✔bone marrow transplant
✔✔What are the risk factors of CML - ✔✔radiation
benzene exposure
✔✔The basic mechanism of _____________________ involves genetic injury to cells
that disrupts growth control and differentiation pathways. - ✔✔malignant transformation
✔✔In CML what are being injured and therefore cannot mature - ✔✔granulocysts
✔✔What are granulocytes - ✔✔blast cells in the myeloid cell lineage developing in WBC
✔✔As the disease progresses, _______________accumulate in large numbers within
the bone marrow and blood and eventually crowd out healthy components of the blood -
✔✔granulocytes
✔✔because it is a myeloproliferative disorder what is this patient at risk of? - ✔✔anemia
infection
bleeding
brusing
✔✔The precise DNA mutation that causes CML is ? - ✔✔Philedelphia chromosome
✔✔what is a phildelphia chromosome - ✔✔abnormally short chromosome 22
