CML STANDARD EXAM SHEET QUESTIONS AND
SOLUTIONS 2025/2026 ALL GRADED A+
✔✔more than 30% of cells are blasts what phase does this relate to - ✔✔terminal
✔✔What is the initial therapy - ✔✔imatinib mesylate
✔✔what are other therapies that can be used - ✔✔chemo
hydroxyurea
bone marrow transplant
✔✔Patients first receive high doses of chemotherapy or radiation to destroy all leukemic
cell-producing bone marrow. The marrow is then replaced with marrow from a
compatible donor, and is used in chronic phase
What is this? - ✔✔Allogenic BMT
✔✔What is important about Allogenic BMT ? - ✔✔it is the only known treatment to
potentially cure CML but not often used because of major side effects
✔✔what are the major complication of CML - ✔✔bleeding
infections
respiratory distress
✔✔why would this patient have pain on the left side and early satiety - ✔✔enlarged
spleen
✔✔why is this patient tired - ✔✔anemia
✔✔what does this patient have DOE or low exercise intolerance - ✔✔due to decreased
O2 capacity to muscles
✔✔weight loss is a sign of? - ✔✔cancer
✔✔why does this patient have splenomegaly? - ✔✔it is compensating by trying to filter
destroyed cells
✔✔papilledema is from? - ✔✔increased ICP
✔✔which nodes are enlarfed - ✔✔cervical and lymp
✔✔what is often the first sign of cancer - ✔✔hypercalcemia
, ✔✔bad cells are taking over and are being increased in production so there is a
decrease in _______ - ✔✔healthy RBC
✔✔what type of anemia is this - ✔✔normochromic normocytic
✔✔no CVAT rules out - ✔✔kidney stones
✔✔osteoporosis affects the - ✔✔bone marrow
✔✔why are we concerned that he has had gout for 25 years and kidney stones? -
✔✔CML will break down cells and the byproduct is uric acid
✔✔what decreases uric acid, treats gout and kidney stones - ✔✔allopurinol
✔✔_________ treats exocrine pancreatic insufficeincy like chronic pancreatitis -
✔✔pancrealipase
✔✔what is significant about the sclera anicteric - ✔✔liver and pancreas are not that bad
and haven't been affected because byproduct of cell destruction is bilirubin and causes
jaundice
✔✔conjugated estrogens treat? - ✔✔hot flashes
✔✔alendronate sodium treats - ✔✔osteoporosis
✔✔feofenadine treats - ✔✔hay fever
✔✔what pre existing health conditions can promote onset of CML - ✔✔Hepatitis
gout
osteoporosis
✔✔what is priapism - ✔✔persistent and painful erection of the penis
✔✔why are patients with CML hyperuricemic - ✔✔because when cells breakdown they
produce uric acid as a byproduct
✔✔Why are infiltrates of leukemic white blood cells found in the skin, lymph nodes, and
central nervous system of patients with chronic myeloge- nous leukemia? - ✔✔It is
myeloproliferative
✔✔Distinguish the pathophysiology of splenomegaly in patients with chronic
myelogenous leukemia from those patients with right heart failure and portal
SOLUTIONS 2025/2026 ALL GRADED A+
✔✔more than 30% of cells are blasts what phase does this relate to - ✔✔terminal
✔✔What is the initial therapy - ✔✔imatinib mesylate
✔✔what are other therapies that can be used - ✔✔chemo
hydroxyurea
bone marrow transplant
✔✔Patients first receive high doses of chemotherapy or radiation to destroy all leukemic
cell-producing bone marrow. The marrow is then replaced with marrow from a
compatible donor, and is used in chronic phase
What is this? - ✔✔Allogenic BMT
✔✔What is important about Allogenic BMT ? - ✔✔it is the only known treatment to
potentially cure CML but not often used because of major side effects
✔✔what are the major complication of CML - ✔✔bleeding
infections
respiratory distress
✔✔why would this patient have pain on the left side and early satiety - ✔✔enlarged
spleen
✔✔why is this patient tired - ✔✔anemia
✔✔what does this patient have DOE or low exercise intolerance - ✔✔due to decreased
O2 capacity to muscles
✔✔weight loss is a sign of? - ✔✔cancer
✔✔why does this patient have splenomegaly? - ✔✔it is compensating by trying to filter
destroyed cells
✔✔papilledema is from? - ✔✔increased ICP
✔✔which nodes are enlarfed - ✔✔cervical and lymp
✔✔what is often the first sign of cancer - ✔✔hypercalcemia
, ✔✔bad cells are taking over and are being increased in production so there is a
decrease in _______ - ✔✔healthy RBC
✔✔what type of anemia is this - ✔✔normochromic normocytic
✔✔no CVAT rules out - ✔✔kidney stones
✔✔osteoporosis affects the - ✔✔bone marrow
✔✔why are we concerned that he has had gout for 25 years and kidney stones? -
✔✔CML will break down cells and the byproduct is uric acid
✔✔what decreases uric acid, treats gout and kidney stones - ✔✔allopurinol
✔✔_________ treats exocrine pancreatic insufficeincy like chronic pancreatitis -
✔✔pancrealipase
✔✔what is significant about the sclera anicteric - ✔✔liver and pancreas are not that bad
and haven't been affected because byproduct of cell destruction is bilirubin and causes
jaundice
✔✔conjugated estrogens treat? - ✔✔hot flashes
✔✔alendronate sodium treats - ✔✔osteoporosis
✔✔feofenadine treats - ✔✔hay fever
✔✔what pre existing health conditions can promote onset of CML - ✔✔Hepatitis
gout
osteoporosis
✔✔what is priapism - ✔✔persistent and painful erection of the penis
✔✔why are patients with CML hyperuricemic - ✔✔because when cells breakdown they
produce uric acid as a byproduct
✔✔Why are infiltrates of leukemic white blood cells found in the skin, lymph nodes, and
central nervous system of patients with chronic myeloge- nous leukemia? - ✔✔It is
myeloproliferative
✔✔Distinguish the pathophysiology of splenomegaly in patients with chronic
myelogenous leukemia from those patients with right heart failure and portal
