CML STUDY GUIDE QUESTIONS AND SOLUTIONS
2025/2026 ALL GRADED A+
✔✔Serine and threonine kinase activity - ✔✔BCR 1 (BREAKPOINT CLUSTER
REGION) exhibits ___ and ___ kinase activity
✔✔Tyrosine kinase activity - ✔✔ABL 1 (ABELSON MURINE LEUKEMIA VIRAL
ONCOGENE) inhibits _____ kinase activity
✔✔Philadelphia Chromosome - ✔✔The formation of this chromosome causes an
increase in blood granulocytes and bone marrow myeloid precursors as the major
proliferative component.
✔✔Granulocytes - ✔✔Philadelphia chromosome causes an increase in blood ____ and
bone marrow myeloid precursors as the major proliferative component
✔✔Hemocytoblast - ✔✔Stem cells for all blood cells
✔✔Hemocytoblast - ✔✔Differentiate into myeloid stem cell and lymphoid stem cells
✔✔Erythropoietin
Thrombopoietin
Colony-stimulating factor - ✔✔What are the 3 myeloid stem cell line
✔✔Erythropoietin - ✔✔In hematopoiesis pathway, what hormone stimulates the
production of erythrocytes via erythropoiesis?
✔✔Thrombopoietin - ✔✔In hematopoiesis pathway, what hormone stimulates the
production of platelets via thrombopoiesis?
✔✔Colony-stimulating factor - ✔✔In hematopoiesis pathway, what hormone stimulates
the production of myeloblast
✔✔Myeloblast - ✔✔Colony-stimulating factor stimulates the production of ____
✔✔Lymphoid stem cell line - ✔✔-differentiates into lymphoblasts which further
differentiates into T-cells and B-cells
✔✔Ionizing radiation
Genetic Association
Chromosomal translocation
Philadelphia chromosome
BCR-ABL gene - ✔✔What are the causes of overproliferation of leukocytes
, ✔✔Ionizing radiation - ✔✔This cause of overproliferation of leukocyte is less common
✔✔Genetic Association - ✔✔This cause of overproliferation of leukocyte is more
common etiology (90% of the time)
✔✔Genetic Association
Chromosomal translocation - ✔✔In this cause of overproliferation of leukocyte has
swapping if genetic material between two chromosomes
✔✔Genetic Association - ✔✔In this cause of overproliferation of leukocyte has
chromosomal translocation
✔✔BCR-ABL gene - ✔✔In this cause of overproliferation of leukocyte produces a
protein that undergoes excessive replication and inhibits apoptosis
✔✔BCR-ABL gene - ✔✔In this activates tyrosine kinase receptor
✔✔Chronic phase
Accelerated phase
Blast phase - ✔✔What are the phases of CML
✔✔Chronic phase - ✔✔80-85% of the patients are in this phase of CML
✔✔Chronic phase - ✔✔This phase of CML shows no symptoms
✔✔Chronic phase - ✔✔In this phase of CML, blast cells are <10%
✔✔Chronic phase - ✔✔In this phase of CML, there's on effect on RBCs
✔✔Chronic phase - ✔✔There's a massive leukocytosis in all cell lines in this phase of
CML
✔✔Chronic phase - ✔✔In this phase of CML, RBCs are neither increased nor
decreased
✔✔Accelerated phase - ✔✔In this phase of CML, more nonfunctional WBCs are formed
✔✔Accelerated phase - ✔✔In this phase of CML, blast cells increased to 10-19%
✔✔Fever and night sweats - ✔✔What is the constitutional symptoms associated in
chronic phase of CML
2025/2026 ALL GRADED A+
✔✔Serine and threonine kinase activity - ✔✔BCR 1 (BREAKPOINT CLUSTER
REGION) exhibits ___ and ___ kinase activity
✔✔Tyrosine kinase activity - ✔✔ABL 1 (ABELSON MURINE LEUKEMIA VIRAL
ONCOGENE) inhibits _____ kinase activity
✔✔Philadelphia Chromosome - ✔✔The formation of this chromosome causes an
increase in blood granulocytes and bone marrow myeloid precursors as the major
proliferative component.
✔✔Granulocytes - ✔✔Philadelphia chromosome causes an increase in blood ____ and
bone marrow myeloid precursors as the major proliferative component
✔✔Hemocytoblast - ✔✔Stem cells for all blood cells
✔✔Hemocytoblast - ✔✔Differentiate into myeloid stem cell and lymphoid stem cells
✔✔Erythropoietin
Thrombopoietin
Colony-stimulating factor - ✔✔What are the 3 myeloid stem cell line
✔✔Erythropoietin - ✔✔In hematopoiesis pathway, what hormone stimulates the
production of erythrocytes via erythropoiesis?
✔✔Thrombopoietin - ✔✔In hematopoiesis pathway, what hormone stimulates the
production of platelets via thrombopoiesis?
✔✔Colony-stimulating factor - ✔✔In hematopoiesis pathway, what hormone stimulates
the production of myeloblast
✔✔Myeloblast - ✔✔Colony-stimulating factor stimulates the production of ____
✔✔Lymphoid stem cell line - ✔✔-differentiates into lymphoblasts which further
differentiates into T-cells and B-cells
✔✔Ionizing radiation
Genetic Association
Chromosomal translocation
Philadelphia chromosome
BCR-ABL gene - ✔✔What are the causes of overproliferation of leukocytes
, ✔✔Ionizing radiation - ✔✔This cause of overproliferation of leukocyte is less common
✔✔Genetic Association - ✔✔This cause of overproliferation of leukocyte is more
common etiology (90% of the time)
✔✔Genetic Association
Chromosomal translocation - ✔✔In this cause of overproliferation of leukocyte has
swapping if genetic material between two chromosomes
✔✔Genetic Association - ✔✔In this cause of overproliferation of leukocyte has
chromosomal translocation
✔✔BCR-ABL gene - ✔✔In this cause of overproliferation of leukocyte produces a
protein that undergoes excessive replication and inhibits apoptosis
✔✔BCR-ABL gene - ✔✔In this activates tyrosine kinase receptor
✔✔Chronic phase
Accelerated phase
Blast phase - ✔✔What are the phases of CML
✔✔Chronic phase - ✔✔80-85% of the patients are in this phase of CML
✔✔Chronic phase - ✔✔This phase of CML shows no symptoms
✔✔Chronic phase - ✔✔In this phase of CML, blast cells are <10%
✔✔Chronic phase - ✔✔In this phase of CML, there's on effect on RBCs
✔✔Chronic phase - ✔✔There's a massive leukocytosis in all cell lines in this phase of
CML
✔✔Chronic phase - ✔✔In this phase of CML, RBCs are neither increased nor
decreased
✔✔Accelerated phase - ✔✔In this phase of CML, more nonfunctional WBCs are formed
✔✔Accelerated phase - ✔✔In this phase of CML, blast cells increased to 10-19%
✔✔Fever and night sweats - ✔✔What is the constitutional symptoms associated in
chronic phase of CML
