PSYC 370 Brain and Behavior II Sleep and Circadian
Rhythms Questions With Complete Solutions
Are free running sleep wake cycles altered by changes in
physical or mental activity? Correct Answer No
Are rods and cones necessary for entrainment? Correct Answer
No, Mice lacking rods and cones display light entrained
circadian cycles
Are Zeitgebers necessary for circadian rhythms? Correct
Answer No, they are seen under constant darkness or constant
light
How are plaques formed in Alzheimer's? Correct Answer
When Amyloid Precursor Protein is processed by B and Y
secretases this yields extracellular b amyloid fragments which
can aggregate to form plaques
How do we know that entrainment involves retinohypothalmic
tracts? Correct Answer Transection of the optic nerves
eliminates the ability of light to entrain, transection of optic
tracts doesn't not
How do we know that sleep affects immune function? Correct
Answer Blood levels of inflammatory cytokines were increased
at the end of the sleep restriction period
How does SCN activity levels correlate with the sleep wake
cycle? Correct Answer Levels of c-fos and Jun-b
, progressively increase across the sleep portion of the sleep/wake
cycles and progressively decrease across the wake portion
How long do breathing pauses last in sleep apnea? Correct
Answer 20-30secs, as many as 20-30 times per hour
How long is a sleep cycle? Correct Answer 90 minutes
How much loss of orexin cells in the hypothalamus do people
with narcolepsy with cataplexy have? Correct Answer 93%,
but have normal numbers of non orexin neurons
How short is the sleep latency in Narcolepsy? Correct Answer
less than 5 minutes
Using the framework that sleep drives metabolic clearance from
the brain, what does an asleep mouse look like? Correct
Answer More than 60% increase in interstitial space
better CSF flow
Effective clearance of metabolites
Using the framework that sleep drives metabolic clearance from
the brain, what does an awake mouse look like? Correct
Answer Reduced interstitial space
Restricted CSF flow
Metabolites accumlate
What are circadian rhythms entrained by? Correct Answer
Zeitgebers
Rhythms Questions With Complete Solutions
Are free running sleep wake cycles altered by changes in
physical or mental activity? Correct Answer No
Are rods and cones necessary for entrainment? Correct Answer
No, Mice lacking rods and cones display light entrained
circadian cycles
Are Zeitgebers necessary for circadian rhythms? Correct
Answer No, they are seen under constant darkness or constant
light
How are plaques formed in Alzheimer's? Correct Answer
When Amyloid Precursor Protein is processed by B and Y
secretases this yields extracellular b amyloid fragments which
can aggregate to form plaques
How do we know that entrainment involves retinohypothalmic
tracts? Correct Answer Transection of the optic nerves
eliminates the ability of light to entrain, transection of optic
tracts doesn't not
How do we know that sleep affects immune function? Correct
Answer Blood levels of inflammatory cytokines were increased
at the end of the sleep restriction period
How does SCN activity levels correlate with the sleep wake
cycle? Correct Answer Levels of c-fos and Jun-b
, progressively increase across the sleep portion of the sleep/wake
cycles and progressively decrease across the wake portion
How long do breathing pauses last in sleep apnea? Correct
Answer 20-30secs, as many as 20-30 times per hour
How long is a sleep cycle? Correct Answer 90 minutes
How much loss of orexin cells in the hypothalamus do people
with narcolepsy with cataplexy have? Correct Answer 93%,
but have normal numbers of non orexin neurons
How short is the sleep latency in Narcolepsy? Correct Answer
less than 5 minutes
Using the framework that sleep drives metabolic clearance from
the brain, what does an asleep mouse look like? Correct
Answer More than 60% increase in interstitial space
better CSF flow
Effective clearance of metabolites
Using the framework that sleep drives metabolic clearance from
the brain, what does an awake mouse look like? Correct
Answer Reduced interstitial space
Restricted CSF flow
Metabolites accumlate
What are circadian rhythms entrained by? Correct Answer
Zeitgebers
