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Both men and women experience bone loss with aging. The bones most likely to demonstrate significant
loss are:
1. Cortical bones
2. Femoral neck bones
3. Cervical vertebrae
4. Pelvic bones - CORRECT ANSWERS 2. Femoral neck bones
Bisphosphonates treat or prevent osteoporosis by:
1. Inhibiting osteoclastic activity
2. Fostering bone resorption
3. Enhancing calcium uptake in the bone
4. Strengthening the osteoclastic proton pump - CORRECT ANSWERS 1. Inhibiting osteoclastic
activity
Prophylactic use of bisphosphonates is recommended for patients with early osteopenia related to long-
term use of which of the following drugs?
1. Selective estrogen receptor modulators
2. Aspirin
3. Glucocorticoids
4. Calcium supplements - CORRECT ANSWERS 3. Glucocorticoids
Patients with cystic fibrosis are often prescribed enzyme replacement for pancreatic secretions. Each
replacement drug has lipase, protease, and amylase components, but the drug is prescribed in units of:
,1. Lipase
2. Protease
3. Amylase
4. Pancreatin - CORRECT ANSWERS 1. Lipase
Brands of pancreatic enzyme replacement drugs are:
1. Bioequivalent
2. About the same in cost per unit of lipase across brands
3. Able to be interchanged between generic and brand-name products to reduce cost
4. None of the above - CORRECT ANSWERS 2. About the same in cost per unit of lipase across
brands
When given subcutaneously, how long until neutral protamine Hagedorn insulin begins to take effect
(onset of action) after administration?
1. 15 to 30 minutes
2. 60 to 90 minutes
3. 3 to 4 hours
4. 6 to 8 hours - CORRECT ANSWERS 2. 60 to 90 minutes
Hypoglycemia can result from the action of either insulin or an oral hypoglycemic. Signs and symptoms
of hypoglycemia include:
1. "Fruity" breath odor and rapid respiration
2. Diarrhea, abdominal pain, weight loss, and hypertension
3. Dizziness, confusion, diaphoresis, and tachycardia
4. Easy bruising, palpitations, cardiac dysrhythmias, and coma - CORRECT ANSWERS 3.
Dizziness, confusion, diaphoresis, and tachycardia
, Nonselective beta blockers and alcohol create serious drug interactions with insulin because they:
1. Increase blood glucose levels
2. Produce unexplained diaphoresis
3. Interfere with the ability of the body to metabolize glucose
4. Mask the signs and symptoms of altered glucose levels - CORRECT ANSWERS 4. Mask the
signs and symptoms of altered glucose levels
Lispro is an insulin analogue produced by recombinant DNA technology. Which of the following
statements about this form of insulin is NOT true?
1. Optimal time of preprandial injection is 15 minutes.
2. Duration of action is increased when the dose is increased.
3. It is compatible with neutral protamine Hagedorn insulin.
4. It has no pronounced peak. - CORRECT ANSWERS 2. Duration of action is increased when
the dose is increased.
The decision may be made to switch from twice daily neutral protamine Hagedorn (NPH) insulin to
insulin glargine to improve glycemia control throughout the day. If this is done:
1. The initial dose of glargine is reduced by 20% to avoid hypoglycemia.
2. The initial dose of glargine is 2 to 10 units per day.
3. Patients who have been on high doses of NPH will need tests for insulin antibodies.
4. Obese patients may require more than 100 units per day. - CORRECT ANSWERS 1. The initial
dose of glargine is reduced by 20% to avoid hypoglycemia.
When blood glucose levels are difficult to control in type 2 diabetes some form of insulin may be added
to the treatment regimen to control blood glucose and limit complication risks. Which of the following
statements is accurate based on research?
1. Premixed insulin analogues are better at lowering HbA1C and have less risk for hypoglycemia.
2. Premixed insulin analogues and the newer premixed insulins are associated with more weight gain
than the oral antidiabetic agents.