CMN 548 Unit 5 | Questions
and Answers
what medications are Isocarboxazid (Marplan), Phenelzine (Nardil), Tranylcypromine
irreversible MAOIs (MAOA&B (Parnate), Selegiline Transdermal (Emasam)
and MAOB MAOB)?
A single dose of irreversible 2 weeks
MAOIs may persist in its
inhibition of MAO for how
long?
What are the most frequent MAOA&B: dizziness, drowsiness, fatigue, headache (without
adverse effects of irreversible increased BP), hyperreflexia, & sleep disturbances
MAOIs?
Reversible MAOIs (RIMAs) Maclobemide (Manerix)
Include what medication?
How long will it take to 24-48 hours
recover MAO activity after a
final dose of RIMA?
What are the most frequent orthostatic hypotension, insomnia, weight gain, edema &
adverse effects of RIMAs? sexual dysfunction, insomnia tx by dividing doses, not
giving after dinner, and using trazodone
Depression, bipolar depression, panic disorder, social phobia,
MAOIs are used to treat what bulimia, PTSD, angina pain, atypical face pain, migraine,
conditions? ADHD, idiopathic orthostatic HTN, & depression r/t brain
, injury
Reversible MAO-A (RIMA) used MDD, dysthymic, chronic
to treat:
Depression, atypical
Irreversible MAOA&B used to
treat: MDD, unresponsive to other antidepressants
Irreversible MAO-B used to treat: MDD in adults
• Avoidance of caffeine, intake of 2L of fluid/day, addition
What is the treatment for MAOI of dietary salt, adjustment of HTN meds, support stockings
induced orthostatic • fludrocortisone 0.1-0.2mg/day for severe cases
hypotension? • Advise pts to get out of bed slowly
, How long should the When changing from one MAOI to another taper and stop use
Psychiatric Nurse Practitioner of the first drug for 10- 14 days before beginning the
wait to begin another second drug
treatment for depression
when stopping an MAOI to
begin either another MAOI
or an SSRI?
How long should the PNP Don't use within 5 weeks of prozac
wait to begin an MAOI after
discontinuing a patient from
fluoxetine (Prozac)?
Describe potential Induction of mania in persons in the depressed phase of BPI
complications for using MAOIs & triggering psychotic decompensating in persons w/
for patients who have Bipolar I schizophrenia
and Schizophrenia.
Results from inactive GI metabolism of dietary
Tyramine due to the MAOI's Sxs: HA usually 1st sx,
severe HTN, stiff neck, diaphoresis, nausea, vomiting
What are the symptoms of a
Management: a-adrenergic antagonists such as
tyramine- induced
phentolamine (regitine) or
hypertensive crisis?
chlorpromazine (thorazine) they will lower BP w/in 5 minutes.
IV furosemide (Lasix) to reduce fluid load, and B-adrenergic
receptor agonists for tachycardia. SL nifedipine (Procardia)
can be given.
Tyramine containing foods 2 weeks
should be avoided for how
long after discontinuing an
and Answers
what medications are Isocarboxazid (Marplan), Phenelzine (Nardil), Tranylcypromine
irreversible MAOIs (MAOA&B (Parnate), Selegiline Transdermal (Emasam)
and MAOB MAOB)?
A single dose of irreversible 2 weeks
MAOIs may persist in its
inhibition of MAO for how
long?
What are the most frequent MAOA&B: dizziness, drowsiness, fatigue, headache (without
adverse effects of irreversible increased BP), hyperreflexia, & sleep disturbances
MAOIs?
Reversible MAOIs (RIMAs) Maclobemide (Manerix)
Include what medication?
How long will it take to 24-48 hours
recover MAO activity after a
final dose of RIMA?
What are the most frequent orthostatic hypotension, insomnia, weight gain, edema &
adverse effects of RIMAs? sexual dysfunction, insomnia tx by dividing doses, not
giving after dinner, and using trazodone
Depression, bipolar depression, panic disorder, social phobia,
MAOIs are used to treat what bulimia, PTSD, angina pain, atypical face pain, migraine,
conditions? ADHD, idiopathic orthostatic HTN, & depression r/t brain
, injury
Reversible MAO-A (RIMA) used MDD, dysthymic, chronic
to treat:
Depression, atypical
Irreversible MAOA&B used to
treat: MDD, unresponsive to other antidepressants
Irreversible MAO-B used to treat: MDD in adults
• Avoidance of caffeine, intake of 2L of fluid/day, addition
What is the treatment for MAOI of dietary salt, adjustment of HTN meds, support stockings
induced orthostatic • fludrocortisone 0.1-0.2mg/day for severe cases
hypotension? • Advise pts to get out of bed slowly
, How long should the When changing from one MAOI to another taper and stop use
Psychiatric Nurse Practitioner of the first drug for 10- 14 days before beginning the
wait to begin another second drug
treatment for depression
when stopping an MAOI to
begin either another MAOI
or an SSRI?
How long should the PNP Don't use within 5 weeks of prozac
wait to begin an MAOI after
discontinuing a patient from
fluoxetine (Prozac)?
Describe potential Induction of mania in persons in the depressed phase of BPI
complications for using MAOIs & triggering psychotic decompensating in persons w/
for patients who have Bipolar I schizophrenia
and Schizophrenia.
Results from inactive GI metabolism of dietary
Tyramine due to the MAOI's Sxs: HA usually 1st sx,
severe HTN, stiff neck, diaphoresis, nausea, vomiting
What are the symptoms of a
Management: a-adrenergic antagonists such as
tyramine- induced
phentolamine (regitine) or
hypertensive crisis?
chlorpromazine (thorazine) they will lower BP w/in 5 minutes.
IV furosemide (Lasix) to reduce fluid load, and B-adrenergic
receptor agonists for tachycardia. SL nifedipine (Procardia)
can be given.
Tyramine containing foods 2 weeks
should be avoided for how
long after discontinuing an
