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1. Hemoglobin (Hgb)
Protein within red blood cells responsible for oxygen transport.
2. Hematocrit (Hct)
Represents the percentage of total blood volume occupied by red blood
cells.
3. Mean Corpuscular Volume (MCV)
Indicates the average size of individual red blood cells.
4. Mean Corpuscular Hemoglobin Concentration (MCHC)
Reflects the average concentration of hemoglobin within red blood
cells.
5. Red Blood Cell Distribution Width (RDW)
Measures variation in RBC size (anisocytosis).
6. Microcytic Anemia
Characterized by small, pale red blood cells (low MCV, low MCHC).
7. Hypochromic Anemia
Defined by reduced hemoglobin concentration, producing pale cells.
8. Iron Deficiency Anemia (IDA)
Caused by insufficient iron intake, chronic blood loss, or malabsorption.
,9. Thalassemia
Inherited genetic disorder affecting hemoglobin chain synthesis; may
cause microcytosis with normal ferritin.
10.Lead Poisoning (Plumbism)
Toxic accumulation of lead interfering with heme synthesis and causing
microcytic anemia.
11.Serum Ferritin
Marker of iron storage levels in the body.
• ↓ Ferritin → Iron Deficiency Anemia
• Normal Ferritin → Thalassemia
• ↑ Ferritin → Inflammation or Iron Overload
12.Serum Iron
Measures circulating iron in the blood.
• ↓ in IDA
• Normal in Thalassemia
13.Total Iron Binding Capacity (TIBC)
Indicates blood’s ability to bind and transport iron.
• ↑ in IDA
• Normal or ↓ in chronic disease
14.Ferritin vs. TIBC Relationship
Ferritin falls while TIBC rises in iron deficiency anemia.
15.Reticulocyte Count
Reflects bone marrow activity and RBC production.
• ↑ Reticulocytes → Active marrow response (hemolysis, blood loss)
• ↓ Reticulocytes → Bone marrow suppression or nutritional deficiency
, 16.Hemoglobin Electrophoresis
Differentiates types of hemoglobin (HbA, HbA2, HbF) — essential in
thalassemia diagnosis.
17.Elevated Total Bilirubin
Indicates increased RBC breakdown seen in hemolytic anemia or
thalassemia.
18.Elemental Iron Dosage for Adults
100–200 mg/day divided doses for iron deficiency anemia.
19.Elemental Iron Dosage for Children
3–6 mg/kg/day based on severity of deficiency.
20.IV Iron Therapy
Indicated when oral iron is ineffective, intolerable, or malabsorbed.
21.Ferric Carboxymaltose
Intravenous formulation infused over ~15 minutes.
22.Lean Body Weight (LBW)
Used to calculate individualized iron dosing requirements.
23.Elemental Iron Dosing Formula
Elemental Iron (mg) = 0.0442 × (Desired Hgb - Observed Hgb) × LBW
24.Low Reticulocyte Count → Implies bone marrow suppression or nutritional
deficiency.
Hemoglobin Electrophoresis Normal - ANSWER Normal distribution of
hemoglobin types.
Hemoglobin Electrophoresis Abnormal in beta-thalassemia - ANSWER
Indicates presence of abnormal hemoglobin in beta-thalassemia.