TEST BANK For Psychopharmacology
Drugs the Brain and Behavior 3rd Edition
By Meyer Nursing, Verified Chapters 1 - 20
WWW.THENURSINGMASTERY.COM
Page 1 of 247
,TABLE OF CONTENTS
Chapter 1. Principles of Pharmacology
Chapter 2. Structure and Function of the Nervous System
Chapter 3. Chemical Signaling by Neurotransmitters and Hormones
Chapter 4. Methods of Research in Psychopharmacology
Chapter 5. Catecholamines
Chapter 6. Serotonin
Chapter 7. Acetylcholine
Chapter 8. Glutamate and GABA
Chapter 9. Drug Abuse and Addiction
Chapter 10. Alcohol
Chapter 11. The Opioids
Chapter 12. Psychomotor Stimulants: Cocaine, Amphetamine, and Related Drugs
Chapter 13. Nicotine and Caffeine
Chapter 14. Marijuana and the Cannabinoids
Chapter 15. Hallucinogens, PCP, and Ketamine
Chapter 16. Inhalants, GHB, and Anabolic-Androgenic Steroids
Chapter 17. Disorders of Anxiety and Impulsivity and the Drugs Used to Treat These Disorders
Chapter 18. Affective Disorders: Antidepressants and Mood Stabilizers
Chapter 19. Schizophrenia: Antipsychotic Drugs
Chapter 20. Neurodegenerative Diseases
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Page 2 of 247
, Chapter 1: Principles of Pharmacology
1.
Which factor most directly determines how quickly a psychoactive drug reaches its target
receptor sites in the brain?
A. Route of administration
B. Drug half-life
C. Protein binding capacity
D. pKa value
ANSWER: A
Rationale: The route of administration (e.g., intravenous vs. oral) determines the speed of
absorption and onset of drug action. IV administration bypasses absorption barriers, allowing
rapid entry into circulation and immediate drug effect.
2.
The bioavailability of a drug is most affected by:
A. Plasma protein binding
B. Drug potency
C. First-pass metabolism
D. Therapeutic index
ANSWER: C
Rationale: Bioavailability refers to the fraction of an administered drug that reaches systemic
circulation. Orally administered drugs undergo first-pass metabolism in the liver, significantly
reducing bioavailability.
3.
Which of the following is true regarding first-pass metabolism?
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Page 3 of 247
, A. It increases drug potency
B. It primarily occurs in the kidneys
C. It reduces the concentration of active drug before it reaches circulation
D. It enhances lipid solubility
ANSWER: C
Rationale: Drugs absorbed from the GI tract travel through the hepatic portal vein to the liver,
where enzymes metabolize part of the drug before it enters the bloodstream, lowering effective
plasma concentration.
4.
A weak acid drug will be more ionized and less lipid-soluble in which environment?
A. Acidic environment
B. Neutral environment
C. Alkaline environment
D. Low-protein environment
ANSWER: C
Rationale: Weak acids remain non-ionized (and thus more lipid-soluble) in acidic pH. In
alkaline pH, they ionize, reducing their ability to cross lipid membranes and slowing absorption.
5.
Which structure serves as the primary protective barrier preventing many substances from
entering the brain?
A. Choroid plexus
B. Blood–brain barrier
C. Area postrema
D. Corpus callosum
ANSWER: B
Rationale: The blood–brain barrier (BBB) restricts movement of water-soluble molecules from
the bloodstream to the brain, maintaining CNS homeostasis. Lipid-soluble drugs can cross it
more easily.
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Page 4 of 247
Drugs the Brain and Behavior 3rd Edition
By Meyer Nursing, Verified Chapters 1 - 20
WWW.THENURSINGMASTERY.COM
Page 1 of 247
,TABLE OF CONTENTS
Chapter 1. Principles of Pharmacology
Chapter 2. Structure and Function of the Nervous System
Chapter 3. Chemical Signaling by Neurotransmitters and Hormones
Chapter 4. Methods of Research in Psychopharmacology
Chapter 5. Catecholamines
Chapter 6. Serotonin
Chapter 7. Acetylcholine
Chapter 8. Glutamate and GABA
Chapter 9. Drug Abuse and Addiction
Chapter 10. Alcohol
Chapter 11. The Opioids
Chapter 12. Psychomotor Stimulants: Cocaine, Amphetamine, and Related Drugs
Chapter 13. Nicotine and Caffeine
Chapter 14. Marijuana and the Cannabinoids
Chapter 15. Hallucinogens, PCP, and Ketamine
Chapter 16. Inhalants, GHB, and Anabolic-Androgenic Steroids
Chapter 17. Disorders of Anxiety and Impulsivity and the Drugs Used to Treat These Disorders
Chapter 18. Affective Disorders: Antidepressants and Mood Stabilizers
Chapter 19. Schizophrenia: Antipsychotic Drugs
Chapter 20. Neurodegenerative Diseases
WWW.THENURSINGMASTERY.COM
Page 2 of 247
, Chapter 1: Principles of Pharmacology
1.
Which factor most directly determines how quickly a psychoactive drug reaches its target
receptor sites in the brain?
A. Route of administration
B. Drug half-life
C. Protein binding capacity
D. pKa value
ANSWER: A
Rationale: The route of administration (e.g., intravenous vs. oral) determines the speed of
absorption and onset of drug action. IV administration bypasses absorption barriers, allowing
rapid entry into circulation and immediate drug effect.
2.
The bioavailability of a drug is most affected by:
A. Plasma protein binding
B. Drug potency
C. First-pass metabolism
D. Therapeutic index
ANSWER: C
Rationale: Bioavailability refers to the fraction of an administered drug that reaches systemic
circulation. Orally administered drugs undergo first-pass metabolism in the liver, significantly
reducing bioavailability.
3.
Which of the following is true regarding first-pass metabolism?
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Page 3 of 247
, A. It increases drug potency
B. It primarily occurs in the kidneys
C. It reduces the concentration of active drug before it reaches circulation
D. It enhances lipid solubility
ANSWER: C
Rationale: Drugs absorbed from the GI tract travel through the hepatic portal vein to the liver,
where enzymes metabolize part of the drug before it enters the bloodstream, lowering effective
plasma concentration.
4.
A weak acid drug will be more ionized and less lipid-soluble in which environment?
A. Acidic environment
B. Neutral environment
C. Alkaline environment
D. Low-protein environment
ANSWER: C
Rationale: Weak acids remain non-ionized (and thus more lipid-soluble) in acidic pH. In
alkaline pH, they ionize, reducing their ability to cross lipid membranes and slowing absorption.
5.
Which structure serves as the primary protective barrier preventing many substances from
entering the brain?
A. Choroid plexus
B. Blood–brain barrier
C. Area postrema
D. Corpus callosum
ANSWER: B
Rationale: The blood–brain barrier (BBB) restricts movement of water-soluble molecules from
the bloodstream to the brain, maintaining CNS homeostasis. Lipid-soluble drugs can cross it
more easily.
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Page 4 of 247
