inflammtion
Acute inflammtion is a protective response of vascular and
supporting elements of a tissue in response to infection and tissue
damage.
Cardinal features
Redness ( Rubor) Due to increased blood flow to the inflamed area.
Heat ( Calor) Due to increased flow of blood at body temperature into
Normally cooler inflamed area.
Pain ( dolor) Due to nerve damage or compression and release of chemicals
that stimulate nerve endings.
Swelling ( tumour) Due to leakage and accumulation of fluid.
Loss of function ( functio Due to combination of factors.
laesa)
Components
Circulating cells - neutrophils, eosinophils, basophils, lymphocytes and monocytes.
Platelets
Circulating proteins - clotting factors, complement components
Vascular endothelium
Connective tissue cells- macrophages, fibroblasts
Extracellular matrix - elastin, collagen