LATEST 2025-2026 COMPLETE EXAM (usmle step
1)MEDICAL EXAMINATION
What is a common cause of pneumonia superimposed on
COPD?-ANSWER-H. flu, Moraxella catarrhalis, Legionella
What condition increases the risk of necrotizing enterocolitis in
a neonate?-ANSWER-Neonatal respiratory distress syndrome
What is the most common lung tumor in male smoker? Female
smoker? Nonsmoker?-ANSWER-Male = squamous, female =
adenocarcinoma, nonsmoker= adenocarcinoma
What cell does bronchioalveolar carcinoma arise from?-
ANSWER-Clara cell
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,Who gets allergic bronchopulmonary aspergillosis and what are
the symptoms?-ANSWER-CF or asthmatic with bronchiectasis;
have cough, dyspnea, and foul smelling sputum
What is the CD4/CD8 ratio in hypersensitivity pneumonitis?
What type of hypersensitivity is it?-ANSWER-Low; type III/IV
What patients get hypersensitivity pneumonitis? What is the
long term effect of exposure?-ANSWER-Farmers, people who
work with birds; granulomas with eosinophils leading to
pulmonary fibrosis
What is dysplastic kidney and how is it inherited?-ANSWER-
Cartilage, cysts in kidney; not inhertiable
What is the BUN/creatinine ratio in prerenal, intrinsic, and
postrenla failure?-ANSWER-Prerenal it is >20, intrinsic is 10–
15, postrenal is >20 initially and then <15 in long standing
damage
What cell produces erythropoietin?-ANSWER-Renal peritubular
interstitial cells
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, What cell creates 1,25 vitamin D?-ANSWER-Proximal tubule
What type of transitional cell carcinoma has early p53
mutations?-ANSWER-Flat pathway (not papillary)
Where does cervical cancer spread to first?-ANSWER-Spreads
locally; invades bladder and results in hydronephrosis
What type of acid/base imbalance is present in pulmonary
embolism? Why does this happen?-ANSWER-Respiratory
alkalosis; irritation of lung stimulates the J receptor, which
increases breathing rate
What is the associated risk for endometriosis of the ovary?-
ANSWER-Increases risk of endometrioid ovarian tumor (or any
other tissue that the endometrial tissue is attached to)
What is the most common malignant and benign germ cell
tumor?-ANSWER-Malignant: dysgerminoma; benign: cystic
teratoma
What is the time definition for sudden infant death syndrome?-
ANSWER-1 month to 1 year
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