NEOPLASIA QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTIONS
(11;14) (q13;q32)
These translocations can be seen in this type of malignancy
correct answers Mantle cell lymphoma
(11;22) (q24;q12)
These translocations can be seen in this type of malignancy
correct answers Ewing sarcoma
(14;18) (q32;q21)
These translocations can be seen in this type of malignancy
correct answers Follicular lymphoma
(7;21) (p22;q22)
(17;21) (p21;q22)
These translocations can be seen in this type of malignancy
correct answers Prostatic adenocarcinoma
(8;14) (q24:q32)
These translocations can be seen in this type of malignancy
correct answers Burkitt lymphoma
1. AML 8q22
2. ETO 21922
3. PML 15922
4. RARA 17q21
These are the Affected Genes in this type of malignancy correct
answers Acute myeloid leukemia (AML)
,2 Components of the Cell Cycle Checkpoints correct answers 1.
Retinoblastoma protein = RB
2. p53
2 examples of Cell Cycle Regulators correct answers 1. Cyclins
2. Cyclin-dependent kinase
2 Tumors with more than one neoplastic cell type, usually
derived from one germ cell layer. correct answers 1. Mixed
Tumors
2. Teratogenous
2 types of agents in direct-acting carcinogens correct answers 1.
alkylating agents
2. acylating agents
2 types of cancer associated with chromosomal deletions correct
answers 1. Retinoblastoma
2. Renal Cell Carcinomas
2 types of Cell Cycle Inhibitors correct answers 1. CIP/KIP
family: p21, p27 (CDKNIA-D)
2. INK4/ARF family (CDKN2A-C)
2 types of Dermatologic Disorders of paraneoplastic syndromes
correct answers 1. Acanthosis nigricans
2. Dermatomyositis
2 types of ionizing radiation that are carcinogenic correct
answers Electromagnetic radiation (X-rays, γ-rays) and
,particulate radiation (α particles, β particles, protons, neutrons).
3 cell cycle components correct answers 1. Cyclins and Cyclin-
Dependent Kinases
2. Cell Cycle Inhibitors
3. Cell Cycle Checkpoint Components
3 types of Carcinogenic Agents correct answers 1. Chemical
Carcinogenesis
2. Radiation Carcinogenesis
3. Microbial Carcinogenesis
4 types of Aromatic Amines, Amides, Azo Dyes of
Procarcinogens correct answers 1. 2-Naphthylamine (B-
naphthylamine)
2. Benzidine
3. 2-Acetylaminofluorene
4. Dimethylamhoazobenzene (butter yellow)
4 types of Vascular and Hematologic Changes of paraneoplastic
syndromes correct answers 1. Venous thrombosis (Trousseau
phenomenon)
2. Disseminated intravascular coagulation
3. Nonbacterial thrombotic endocarditis
4. Red cell aplasia
5 types of Natural Plant and Microbial Products of
Procarcinogens correct answers 1. Aflatoxin B,
2. Griseofulvin
3. Cycasin
, 4. Safrole
5. Betel nuts
6 components in Cancer-Enabling Inflammation correct answers
1. Proliferation Promotion
2. Removal of Growth Suppressors
3. Resistance to Cell Death
4. Inducing Angiogenesis
5. Activating Invasion and Metastasis
6. Evading Immune Destruction
A benign epithelial neoplasm derived from glandular tissues,
even if the tumor cells do not form glandular structures. correct
answers adenoma
A carcinoma in which the neoplastic epithelial cells grow in a
glandular pattern. correct answers adenocarcinoma
A carcinoma in which the tumor cells resemble stratified
squamous epithelium. correct answers squamous cell carcinoma
A chromosomal rearrangement that creates a fusion gene
encoding a chimeric oncoprotein. correct answers Philadelphia
chromosome
A disorder characterized by gray-black patches of thickened,
hyperkeratotic skin with a velvety appearance. correct answers
Acanthosis nigricans
COMPLETE SOLUTIONS
(11;14) (q13;q32)
These translocations can be seen in this type of malignancy
correct answers Mantle cell lymphoma
(11;22) (q24;q12)
These translocations can be seen in this type of malignancy
correct answers Ewing sarcoma
(14;18) (q32;q21)
These translocations can be seen in this type of malignancy
correct answers Follicular lymphoma
(7;21) (p22;q22)
(17;21) (p21;q22)
These translocations can be seen in this type of malignancy
correct answers Prostatic adenocarcinoma
(8;14) (q24:q32)
These translocations can be seen in this type of malignancy
correct answers Burkitt lymphoma
1. AML 8q22
2. ETO 21922
3. PML 15922
4. RARA 17q21
These are the Affected Genes in this type of malignancy correct
answers Acute myeloid leukemia (AML)
,2 Components of the Cell Cycle Checkpoints correct answers 1.
Retinoblastoma protein = RB
2. p53
2 examples of Cell Cycle Regulators correct answers 1. Cyclins
2. Cyclin-dependent kinase
2 Tumors with more than one neoplastic cell type, usually
derived from one germ cell layer. correct answers 1. Mixed
Tumors
2. Teratogenous
2 types of agents in direct-acting carcinogens correct answers 1.
alkylating agents
2. acylating agents
2 types of cancer associated with chromosomal deletions correct
answers 1. Retinoblastoma
2. Renal Cell Carcinomas
2 types of Cell Cycle Inhibitors correct answers 1. CIP/KIP
family: p21, p27 (CDKNIA-D)
2. INK4/ARF family (CDKN2A-C)
2 types of Dermatologic Disorders of paraneoplastic syndromes
correct answers 1. Acanthosis nigricans
2. Dermatomyositis
2 types of ionizing radiation that are carcinogenic correct
answers Electromagnetic radiation (X-rays, γ-rays) and
,particulate radiation (α particles, β particles, protons, neutrons).
3 cell cycle components correct answers 1. Cyclins and Cyclin-
Dependent Kinases
2. Cell Cycle Inhibitors
3. Cell Cycle Checkpoint Components
3 types of Carcinogenic Agents correct answers 1. Chemical
Carcinogenesis
2. Radiation Carcinogenesis
3. Microbial Carcinogenesis
4 types of Aromatic Amines, Amides, Azo Dyes of
Procarcinogens correct answers 1. 2-Naphthylamine (B-
naphthylamine)
2. Benzidine
3. 2-Acetylaminofluorene
4. Dimethylamhoazobenzene (butter yellow)
4 types of Vascular and Hematologic Changes of paraneoplastic
syndromes correct answers 1. Venous thrombosis (Trousseau
phenomenon)
2. Disseminated intravascular coagulation
3. Nonbacterial thrombotic endocarditis
4. Red cell aplasia
5 types of Natural Plant and Microbial Products of
Procarcinogens correct answers 1. Aflatoxin B,
2. Griseofulvin
3. Cycasin
, 4. Safrole
5. Betel nuts
6 components in Cancer-Enabling Inflammation correct answers
1. Proliferation Promotion
2. Removal of Growth Suppressors
3. Resistance to Cell Death
4. Inducing Angiogenesis
5. Activating Invasion and Metastasis
6. Evading Immune Destruction
A benign epithelial neoplasm derived from glandular tissues,
even if the tumor cells do not form glandular structures. correct
answers adenoma
A carcinoma in which the neoplastic epithelial cells grow in a
glandular pattern. correct answers adenocarcinoma
A carcinoma in which the tumor cells resemble stratified
squamous epithelium. correct answers squamous cell carcinoma
A chromosomal rearrangement that creates a fusion gene
encoding a chimeric oncoprotein. correct answers Philadelphia
chromosome
A disorder characterized by gray-black patches of thickened,
hyperkeratotic skin with a velvety appearance. correct answers
Acanthosis nigricans
